Induction of Stress Granule Assembly is Essential for the Orchestration of DNA Damage Response

DNA damage provokes several responses including DNA repair, cell cycle regulation and apoptosis that collectively represent the DNA damage response (DDR). Here, we demonstrate that the DDR incorporates the activation of stress granule (SG) formation pathway as a mechanism to process destabilized RNAs. UV irradiation induced the assembly of SGs during the G2 phase and newly formed SGs appeared exclusively in the early G1 phase. SG assembly pathway was activated within the first hours after DNA damage, suggesting that the processing of destabilized RNAs is activated at an early stage. The induction of SGs and RNAi effector protein Argonaute 2 recruitment after UV exposure was independent of ATM and ATR signaling cascades. Apoptosis occurred only in SG-negative cells indicating that SGs promote cell survival after genotoxic stress. Analysis of several DNA damage/repair deficient MEFs revealed that the SG accumulation remained unaltered after UV exposure. Our results show that SGs are an essential component of DDR that is activated in parallel to the DNA damage kinase response networks

Media Takes: On Aging

With the longevity revolution, humankind enters a new and unprecedented stage of development, the impact of which is even greater because of its rapidity. This report/styleguide is an important step in overcoming ageist language and beliefs by providing journalists and others who work in the media with an appropriate body of knowledge, including a lexicon that helps redefine and navigate this new world

Biases at the Ballot Box: How Multiple Forms of Voter Discrimination Impede the Descriptive and Substantive Representation of Ethnic Minority Groups

Research shows that ethnic minority candidates often face an electoral penalty at the ballot box. In this study, we argue that this penalty depends on both candidate and voter characteristics, and that pro-minority policy positions incur a greater penalty than a candidate’s ethnic background itself. Using a conjoint experiment embedded in a panel study of British voters, we investigate the relative contributions of candidate ethnicity, policy positions, affirmative action, and voter attitudes to this electoral penalty. We find that although Pakistani (Muslim) candidates are penalized directly for their ethnicity, black Caribbean candidates receive on average the same levels of support as white British ones. However, black Caribbean candidates suffer conditional discrimination where they are penalized if they express support for pro-minority policies, and all candidates are penalized for having been selected through an affirmative action initiative. We also find that some white British voters are more inclined to support a black Caribbean candidate than a white British one, all else being equal. These voters (one quarter of our sample) have cosmopolitan views on immigration, and a strong commitment to anti-prejudice norms. However, despite efforts across parties to increase the ethnic diversity of candidates for office, many voters’ preferences continue to pose barriers toward descriptive and substantive representation of ethnic minority groups

Design of all electric secondary power system for future advanced MALE UAV

SAvE (Systems for UAV Alternative Energy) is a research project funded in 2007 by Piemonte Regional Government, Italy, and assigned to Politecnico di Torino and Alenia Aeronautica. Aim of the project is the study of new, more efficient, more effective and more environmentally friendly on board systems for future advanced Unmanned Aerial Vehicles (UAV), particularly for future advanced MALE UAVs. The paper deals with the analysis and design of the all electric Secondary Power System of a future advanced MALE UAV, that we consider as "reference aircraft". After a thorough trade-off analysis of different configurations of the Secondary Power System, the hybrid configuration, characterized by generators (or better, starter/generators), fuel cells and traditional and innovative batteries, has been selected as the most promising. Detailed investigations to find the best way to apportion the supply of secondary power, considering the various power sources (generators or starter/generators, batteries and fuel cells) in the different modes of operations, have been performed thanks to an integrated simulation environment, where physical, functional and mission scenario simulations continuously exchange data and results

Other-regarding behaviour: Testing guilt- and reciprocity-based models

We analyse two types of belief-dependant models of social preferences: guilt aversion and reciprocity. In particular, we test the relevance of their input variables (second-order beliefs and general dispositions for guilt/reciprocity). The data confirm the predictions of belief-dependant models. Both second-order beliefs and a participant's sensitivity to guilt/reciprocity are relevant for the decisions taken. Second-order beliefs appear to have an inverse U-shaped effect on the extent of kind behaviour.social preferences, other-regarding behaviour, belief-dependent models, experiments, trust game, guilt aversion, beliefs, psychological game theory, emotions, reciprocity

Staple Food Consumption Patterns in Urban Zambia: Results from the 2007/2008 Urban Consumption Survey

• The Zambia Urban Consumption Survey, a survey of 1,865 urban households in Lusaka, Kitwe, Mansa, and Kasama, was conducted in August 2007 and February 2008 by the Central Statistical Office in collaboration with the Zambia Food Security Research Project. • Survey results indicate that in Lusaka and Kitwe, wheat has overtaken maize as the most important staple in terms of urban consumer expenditures. Maize is no longer the dominant staple food in urban Zambia, except among the poor. This finding is consistent with broader regional trends toward declining dependence on maize for urban staple food needs. • Hammer-milling services are readily available to the vast majority of urban households and in most cases their cheapest maize meal option is to obtain maize grain and have it custom-milled for a fee. However, maize grain is not consistently available in public markets during the lean season (December-March). GRZ could promote urban food security by ensuring that maize grain is available in public markets at all times. • In Kasama and Mansa, and particularly among relatively poor households, cassava is an important consumption item and serves as a buffer against high maize prices and poor maize grain availability during the lean season. • Supermarkets have only 5-17% of the market share for staple foods and are frequented mainly by wealthier households. Urban consumers are heavily dependent upon non-supermarket, informal retail outlets such as public markets and grocers for their staple food purchases. Policies and public investments to support these traditional retailers, help them operate more efficiently, and reduce the transaction costs they face may have higher payoffs for most urban consumers as well as smallholder farmers than policies presupposing the rapid takeover of supermarkets and other more formal retail channels.Zambia, food security, consumption, household, urban, Agricultural and Food Policy, Community/Rural/Urban Development, Consumer/Household Economics, Food Security and Poverty, International Development, q19,