Domestic violence against infertile women in Karachi, Pakistan

This study investigates the prevalence of physical and psychological violence against infertile women in Karachi, Pakistan. A total of 400 infertile women attending the selected infertility clinics in Karachi, Pakistan were interviewed using the to investigate their experiences of physical and psychological violence. Out of 400 infertile women, 278 (64%) reported to be the victims of violence during the last 12 months before they were interviewed. Nearly one quarter (23.1%) reported facing physical violence. All women reported their husbands and their family members to be the perpetrators. It is concluded that Clinicians should identify the abused women and provide them with medical care and supportive counseling

Health seeking behavior of couples with secondary infertility

OBJECTIVE: To determine the factors affecting the health-seeking behavior of couples with secondary infertility in Karachi. DESIGN: A descriptive case series. PLACE AND DURATION OF STUDY: The data was collected from women attending infertility clinics in five tertiary care hospitals in Karachi from March to June 2003. PATIENTS AND METHODS: All currently married women, between the age of 15-35 years, with at least one previous conception, irrespective of outcome, attending an infertility clinic and consenting to participate in the study, were included. Women with corrective surgery on vagina and uterus, and cases of primary infertility, were excluded. Multiple logistic regression models were used to determine the association of various factors, affecting the health-seeking behavior, with statistical significance set at p \u3c 0.05 for the covariates and the interaction terms between various factors. RESULTS: The women consulted multiple health care providers for treatment of secondary infertility. The main reasons for seeking treatment were couple s wish (54.2%), family pressure (22.6%) and want of a son by husbands or in-laws (20.4%). The most commonly sought providers were physicians (74.7%), Traditional Birth Attendants (TBA, 39.5%), Spiritual healers (26%), Hakeems (23%) and Homeopaths (17.2%). Most of the women who consulted non-physicians were illiterate (69.4%) as compared to those who consulted a physician (37.8%, p-value = 0.00). The non-physicians were more commonly consulted by women belonging to low socioeconomic group. The posttreatment complications were more common among women who consulted non-physicians. CONCLUSION: Pressure from husbands and in-laws compels women for consulting multiple providers. Health seeking behavior for infertility is affected by the literacy and socioeconomic status of the women

Reproductive tract infections among married women in peri-urban areas of Karachi, Pakistan: A population-based study

Background: Reproductive Tract Infections (RTIs) is a major public health problem. In Pakistan, there is dearth of information about the prevalence of RTIs among women and their health seeking behavior. A study was conducted to determine the prevalence, number and types of RTIs among women residing in squatter settlements in Karachi and their health seeking behavior.Methods: The respondents were married non-pregnant women aged 15–49 years residing in peri-urban areas of Karachi, Pakistan. The interviews with women were followed by their physical and pelvic examinations. Samples swabs collected from vagina and endocervix were tested in laboratory.Results: Overall, 23.8% of the women had laboratory-diagnosed RTIs. Nearly 2.6% had trichomoniasis and 1.7% were positive for syphilis. Bacterial vaginosis was diagnosed in 8.8% and vaginal candidiasis in 13.2 %.Conclusion: The study indicates a high prevalence of RTIs among women with Bacterial vaginosis and trichomoniasis to be the most prevalent endogenous infection and STI respectively. The women considered many symptoms as normal and did not seek treatment. These are the cases that have a potential to remain infected for a long time

Adoption practices among couples with secondary infertility in Karachi: a triangulation study design

Objective: To explore the perceptions and experiences of couples with secondary infertility regarding adoption practices; to estimate the prevalence of adoption among couples with secondary infertility, and to study the adopted child preference pattern. Methods: To fulfill the objectives of the study both qualitative and quantitative study designs were utilized. In qualitative explorative study design, three Focus Group discussions were conducted with married fertile women to explore their perceptions for adoption practices. Moreover, eight in-depth interviews were conducted with women with secondary infertility to explore their experiences. For quantitative methodology, a case series of 400 secondary infertile couples was conducted. Results: Qualitative methodology result suggests that adoption is the last option for infertile couples. Couples often take this as a Totka , that when they adopt a child, they could end up having their own baby. The husband\u27s family is usually preferred for adopting a child. The results of quantitative component suggest that the prevalence of adoption among 400 women is 7%. Less than half of the respondents (49.3%) reported to ever having thought of adopting a child to cope with the secondary infertility. The main decision maker for adoption of child is the husband (17%) and the mother-in-law (68%). Though majority of these women (72.5%) were supported by their husbands, however, in-laws and relatives were reluctant to pursue this option and less than one third (29%) of these women had a support from them. Conclusions: This study concludes that couples ever thought of or opted for adoption after prolonged duration of secondary infertility. In cses where the condition cannot be treated, it is necessary to counsel, not only the couple but also the in-laws (JPMA 57:55;2007)

Synthesis of Schiff bases derived from 2-hydroxy-1- naphth- aldehyde and their tin(II) complexes for antimicribial and antioxidant activities

The current studies were designed to prepare tin(II) complexes of various Schiff base derivatives of 2-hydroxy-1-naphthaldehyde (HN) with L-histidine and sulfamethazine have been prepared and characterized by different physiochemical studies such as elemental analysis, atomic absorption, UV-Vis spectra, FTIR spectra, 1H–NMR, 13C-NMR and conductance studies. Antimicrobial and antioxidant activities were also calculated. Antibacterial activity was evaluated by the agar-well diffusion method. Two Gram-negative (Klebsiella pneumoniae and Escherichia coli) and three Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) bacterial strains were used. Antifungal activity was resolute against three fungal strains (Aspergillus niger, Aspergillus flavus and Alternaria solani) by using the agar tube dilution method. The antioxidant activity of ligands and their complexes was measured on the basis of the radical scavenging effect of 1,1-diphenyl-2-picryl-hydrazyl (DPPH)-free radical activity. Ligand HNSM exhibited excellent activities as antibacterial activity (22 mm), antifungal activity (55%) and antioxidant activity (119 ppm).               KEY WORDS: Schiff base, 2-Hydroxy-1-naphthaldehyde, L-Histidine and sulfamethazine, Tin(II) complexes, Antimicrobial activities, Antioxidant activities Bull. Chem. Soc. Ethiop. 2017, 31(3), 445-456. DOI: http://dx.doi.org/10.4314/bcse.v31i3.

Geographic access to working family planning centers and unintended pregnancies among married women: a community based nested case control study.

Background: Unintended pregnancies pose substantial risk to mothers and children. In Pakistan, unintended pregnancies account for 46% of all pregnancies. Lack of geographic access to open and well-supplied family planning (FP) centers may be related to the occurrence of such pregnancies, particularly in rural areas. Objective: The objective of this analysis is to determine if geographic access to family planning centers in the Thatta district of Pakistan is related to unintended pregnancy rates among married women. Methods: We conducted a community-based, nested case-control study of 800 pregnant women identified from the database of an active surveillance system, which registers and follows all pregnant women in the catchment area of Thatta district. Women were enrolled during the first trimester; those that reported their pregnancy to be unintended were selected as cases (n = 200), and those whose pregnancies were intended served as controls (n = 600). We defined geographic access as including both the distance of a family planning center from the woman’s home, and availability of personal transportation. Logistic regression was used for analysis. Results: In the multivariate model, neither distance [OR = 1.0; 95% CI (0.95 - 1.05)] nor availability of transportation [OR = 1.14; 95% CI (0.78 - 1.67)] were significantly associated with unintended pregnancy. In fact, women with unintended pregnancies were more likely to be aware of family planning [OR = 2.21; 95% CI (1.23 - 3.97)] and more likely to have been using a contraceptive method before conceiving their index pregnancy [OR = 3.59; 95% CI (1.83 - 7.06)]. Other factors related to unintended pregnancy were older maternal age [OR = 1.13; 95% CI (1.08 - 1.17)], having already had at least one son [OR = 3.13; 95% CI (1.93 - 5.07)]; spousal opposition to contraceptive use, [OR = 3.24; 95% CI (1.89 - 5.56)] and low spousal education level [OR = 1.85; 95% CI (1.08 - 3.18)] as compared to women with intended pregnancy. Conclusion: Lack of geographic access to FP centers is not a risk factor for unintended pregnancy in women from the Thatta district. However, in this population, unintended pregnancies are more common among older women, women having at least one son, and those who have a spouse who does not approve of contraceptive use, and is less educated. Of note, women who reported unintended pregnancy did have knowledge about FP and were more often using contraceptives before they conceived

Synthesis and evaluation of novel antifungal agents targeted to the plasma membrane H[+]-ATPase

A library of dienones were synthesized as candidate antifungal agents. These compounds were screened against Saccharomyces cerevisiae and Candida albicans using macro-broth susceptibility assay. The dienones exhibited a broad range of inhibition against S. cerevisiae (0.2-99%) and C. albicans (0-99%). 3,5-bis(p- trifluoromethylbenzylidene)-1-methyl-piperidine-4-one was identified as the most potent inhibitor of S. cerevisiae. Whereas, the most promising inhibitor of C. albicans was 2,6-bis(pyridine-3ylmethylene)cyclohexan-1-one

Knowledge, perceptions and myths regarding infertility among selected adult population in Pakistan: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>The reported prevalence of infertility in Pakistan is approximately 22% with 4% primary and 18% secondary infertility. Infertility is not only a medical but also a social problem in our society as cultural customs and perceived religious dictums may equate infertility with failure on a personal, interpersonal, or social level. It is imperative that people have adequate knowledge about infertility so couples can seek timely medical care and misconceptions can be rectified.</p> <p>We aim to assess the knowledge, perception and myths regarding infertility and suggest ways to improve it.</p> <p>Methods</p> <p>A cross-sectional survey was carried out by interviewing a sample of 447 adults who were accompanying the patients at two tertiary care hospitals in Karachi, Pakistan. They were interviewed one-on-one with the help of a pretested questionnaire drafted by the team after a thorough literature review and in consultation with infertility specialists.</p> <p>Results</p> <p>The correct knowledge of infertility was found to be limited amongst the participants. Only 25% correctly identified when infertility is pathological and only 46% knew about the fertile period in women's cycle. People are misinformed that use of IUCD (53%) and OCPs (61%) may cause infertility. Beliefs in evil forces and supernatural powers as a cause of infertility are still prevalent especially amongst people with lower level of education. Seeking alternative treatment for infertility remains a popular option for 28% of the participant as a primary preference and 75% as a secondary preference. IVF remains an unfamiliar (78%) and an unacceptable option (55%).</p> <p>Conclusions</p> <p>Knowledge about infertility is limited in the population and a lot of misconceptions and myths are prevalent in the society. Alternative medicine is a popular option for seeking infertility treatment. The cultural and religious perspective about assisted reproductive technologies is unclear, which has resulted in its reduced acceptability.</p

A prospective study of maternal, fetal and neonatal deaths in low- and middle-income countries

To quantify maternal, fetal and neonatal mortality in low- and middle-income countries, to identify when deaths occur and to identify relationships between maternal deaths and stillbirths and neonatal deaths

Experience of partner\u27s violence among married women in a squatter settlement of Karachi, Pakistan

This study investigated the wife experience of verbal and physical violence from their husbands, aimed to estimate the prevalence of interpersonal violence and to identify the reasons among women in squatter settlements of Karachi, Pakistan. The data was collected using a cross-sectional study design, by structured interviewing 400 currently married women. Seventy percent (283) of the study subjects reported verbal violence while 25% (100) women reported for physical violence. Women felt mental pressure due to verbal violence as 89% (253/283). The main reasons for physical violence were: in-laws (26%), wife arguing 24%, stopping husband for smoking 17%, taunting the children by the husbands/ in-laws 14%, financial constraints 13%, house-hold chores 7%, stopping the husbands for any thing by wife 6%, women had abortion 5%, followed by others. The qualitative phase of study emerged the themes that husbands violence is the part of normal life of women, Health professionals should be helping victims, and government as state should provide support through women police and women advocates. This study revealed the high prevalence of verbal and physical interpersonal violence, which needs the attention of health professionals and policy makers. There is a need to provide awareness among the society