55 research outputs found
Probing the Surfaces of Interstellar Dust Grains: The Adsorption of CO at Bare Grain Surfaces
A solid-state feature was detected at around 2175 cm-1 towards 30 embedded
young stellar objects in spectra obtained using the ESO VLT-ISAAC. We present
results from laboratory studies of CO adsorbed at the surface of Zeolite
wafers, where absorption bands were detected at 2177 and 2168 cm-1
(corresponding to CO chemisorbed at the Zeolite surface), and 2130 cm-1
(corresponding to CO physisorbed at the Zeolite surface), providing an
excellent match to the observational data. We propose that the main carrier of
the 2175-band is CO chemisorbed at bare surfaces of dust grains in the
interstellar medium. This result provides the first direct evidence that
gas-surface interactions do not have to result in the formation of ice mantles
on interstellar dust. The strength of the 2175-band is estimated to be ~ 4 x
10-19 cm molecule-1. The abundance of CO adsorbed at bare grain surfaces ranges
from 0.06 to 0.16 relative to H2O ice, which is, at most, half of the abundance
(relative to H2O ice) of CO residing in H2O-dominated ice environments. These
findings imply that interstellar grains have a large (catalytically-active)
surface area, providing a refuge for interstellar species. Consequently the
potential exists for heterogeneous chemistry to occur involving CO molecules in
unique surface chemistry pathways not currently considered in gas-grain models
of the interstellar medium.Comment: 19 pages inc. 3 figures 2 tables, accepted for publication in MNRA
The role of anti-aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica
Background: Acute brainstem syndrome (ABS) may herald multiple sclerosis (MS), neuromyelitis optica (NMO), or occur as an isolated syndrome. The aquaporin 4 (AQP4)-specific serum autoantibody, NMO-IgG, is a biomarker for NMO. However, the role of anti-AQP4 antibody in the conversion of ABS to NMO is unclear.
Methods: Thirty-one patients with first-event ABS were divided into two groups according to the presence of anti-AQP4 antibodies, their clinical features and outcomes were retrospectively analyzed.
Results: Fourteen of 31 patients (45.16 %) were seropositive for NMO-IgG. The 71.43 % of anti-AQP4 (+) ABS patients converted to NMO, while only 11.76 % of anti-AQP4 (-) ABS patients progressed to NMO. Anti-AQP4 (+) ABS patients demonstrated a higher IgG index (0.68 ± 0.43 vs 0.42 ± 0.13, p < 0.01) and Kurtzke Expanded Disability Status Scale (4.64 ± 0.93 vs 2.56 ± 0.81, p < 0.01) than anti-AQP4 (-) ABS patients. Area postrema clinical brainstem symptoms occurred more frequently in anti-AQP4 (+) ABS patients than those in anti-AQP4 (-) ABS patients (71.43 % vs 17.65 %, p = 0.004). In examination of magnetic resonance imaging (MRI), the 78.57 % of anti-AQP4 (+) ABS patients had medulla-predominant involvements in the sagittal view and dorsal-predominant involvements in the axial view.
Conclusions: ABS represents an inaugural or limited form of NMO in a high proportion of anti-AQP4 (+) patients
Intractable hiccups induced by high-dose intravenous methylprednisolone in a patient with multiple sclerosis
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