Neuronal and non-neuronal signals regulate <i>Caernorhabditis elegans</i> avoidance of contaminated food

One way in which animals minimise the risk of infection is to reduce their contact with contaminated food. Here we establish a model of pathogen-contaminated food avoidance using the nematode worm Caernorhabditis elegans. We find that avoidance of pathogen-contaminated food protects C. elegans from the deleterious effects of infection and, using genetic approaches, demonstrate that multiple sensory neurons are required for this avoidance behaviour. In addition, our results reveal that avoidance of contaminated food requires bacterial adherence to non-neuronal cells in the tail of C. elegans that are also required for the cellular immune response. Previous studies in C. elegans have contributed significantly to our understanding of molecular and cellular basis of host-pathogen interactions and our model provides a unique opportunity to gain basic insights into how animals avoid contaminated food

Collinearity, convergence and cancelling infrared divergences

The Lee-Nauenberg theorem is a fundamental quantum mechanical result which provides the standard theoretical response to the problem of collinear and infrared divergences. Its argument, that the divergences due to massless charged particles can be removed by summing over degenerate states, has been successfully applied to systems with final state degeneracies such as LEP processes. If there are massless particles in both the initial and final states, as will be the case at the LHC, the theorem requires the incorporation of disconnected diagrams which produce connected interference effects at the level of the cross-section. However, this aspect of the theory has never been fully tested in the calculation of a cross-section. We show through explicit examples that in such cases the theorem introduces a divergent series of diagrams and hence fails to cancel the infrared divergences. It is also demonstrated that the widespread practice of treating soft infrared divergences by the Bloch-Nordsieck method and handling collinear divergences by the Lee-Nauenberg method is not consistent in such cases.Comment: 29 pages, 17 figure

Colour, copies and confinement

In this paper we construct a wide class of Gribov copies in Coulomb gauge SU(2) gauge theory. Infinitesimal copies are studied in some detail and their non-perturbative nature is made manifest. As an application it is shown that the copies prevent a non-perturbative definition of colour charge.Comment: 25 pages, 10 figures. Minor changes, two references added. Published versio

Infra-Red Finite Charge Propagation

The Coulomb gauge has a long history and many uses. It is especially useful in bound state applications. An important feature of this gauge is that the matter fields have an infra-red finite propagator in an on-shell renormalisation scheme. This is, however, only the case if the renormalisation point is chosen to be the static point on the mass shell, p = (m, 0, 0, 0). In this letter we show how to extend this key property of the Coulomb gauge to an arbitrary relativistic renormalisation point. This is achieved through the introduction of a new class of gauges of which the Coulomb gauge is a limiting case. A physical explanation for this result is given.Comment: 8 pages, plain TeX, to appear in Modern Physics Letters

The relationships between health anxiety, online health information seeking, and cyberchondria: Systematic review and meta-analysis

© 2018 Background: Cyberchondria refers to an abnormal behavioral pattern in which excessive or repeated online searches for health-related information are distressing or anxiety-provoking. Health anxiety has been found to be associated with both online health information seeking and cyberchondria. The aims of the present systematic review and meta-analysis were to examine the magnitude of these associations and identify any moderator variables. Methods: A systematic literature search was performed across several databases (PsycINFO, PubMed, Embase) and reference lists of included studies. Results: Twenty studies were included across two independent meta-analyses, with 7373 participants. Random effects meta-analyses showed that there was a positive correlation between health anxiety and online health information seeking [r = 0.34, 95% CI (0.20, 0.48), p <.0001], and between health anxiety and cyberchondria [r = 0.62, 95% CI (0.52, 0.71), p <.0001]. A meta-regression indicated that the age of study participants [Q(1) = 4.58, p =.03] was partly responsible for the heterogeneity found for the relationship between health anxiety and cyberchondria. Limitations: The generalizability and validity of our findings are restricted by the methodological limitations of the primary studies, namely, an over-reliance on a single measure of cyberchondria, the Cyberchondria Severity Scale. Conclusions: Our review found a positive correlation between health anxiety and online health information seeking, and between health anxiety and cyberchondria. Further research should aim to explore the contexts for these associations as well as address the identified limitations of the extant literature

BRST operator quantization of generally covariant gauge systems

The BRST generator is realized as a Hermitian nilpotent operator for a finite-dimensional gauge system featuring a quadratic super-Hamiltonian and linear supermomentum constraints. As a result, the emerging ordering for the Hamiltonian constraint is not trivial, because the potential must enter the kinetic term in order to obtain a quantization invariant under scaling. Namely, BRST quantization does not lead to the curvature term used in the literature as a means to get that invariance. The inclusion of the potential in the kinetic term, far from being unnatural, is beautifully justified in light of the Jacobi's principle.Comment: 16 pages (LaTeX manuscript). Revised version (minor changes) to appear in Physical Review

Computer Simulation of Levee Erosion and Overtopping

Improved computer models of erosion have been developed, considering soil hydraulic conductivity. The models deal with erosion of levees, dams and embankments due to overtopping. The simulations trace the formation of rills and gullies, beginning with initial overtopping and continuing to final breaching. Physical models performed at 1-g and high g using a geotechnical centrifuge have been used to calibrate the models. Previous models did not consider soil hydraulic conductivity, and although results were quite good for the formation of rills and gullies and sediment quantities, breach times were underestimated. Essentially the water flow was treated as if passing over a solid surface, not entering the soil, and the total water flow was available for erosion. Thus, breach times were underestimated. Soil erodibility parameters had to be adjusted in order to achieve good agreement with breach times. The new models developed consider soil hydraulic conductivity, and produce good agreement with the performance of the physical modeling, including breach times and the use of proper soil erodibility parameters

Somatostatin 2 receptors in the spinal cord tonically restrain thermogenic, cardiac and other sympathetic outflows

The anatomical and functional characterization of somatostatin (SST) and somatostatin receptors (SSTRs) within the spinal cord have been focused in the dorsal horn, specifically in relation to sensory afferent processing. However, SST is also present within the intermediolateral cell column (IML), which contains sympathetic preganglionic neurons (SPN). We investigated the distribution of SSTR2 within the thoracic spinal cord and show that SSTR2A and SSTR2B are expressed in the dorsal horn and on SPN and non-SPN in or near the IML. The effects of activating spinal SSTR and SSTR2 were sympathoinhibition, hypotension, bradycardia, as well as decreases in interscapular brown adipose tissue temperature and expired CO2, in keeping with the well-described inhibitory effects of activating SSTR receptors. These data indicate that spinal SST can decrease sympathetic, cardiovascular and thermogenic activities. Unexpectedly blockade of SSTR2 revealed that SST tonically mantains sympathetic, cardiovascular and thermogenic functions, as activity in all measured parameters increased. In addition, high doses of two antagonists evoked biphasic responses in sympathetic and cardiovascular outflows where the initial excitatory effects were followed by profound but transient falls in sympathetic nerve activity, heart rate and blood pressure. These latter effects, together with our findings that SSTR2A are expressed on GABAergic, presumed interneurons, are consistent with the idea that SST2R tonically influence a diffuse spinal GABAergic network that regulates the sympathetic cardiovascular outflow. As described here and elsewhere the source of tonically released spinal SST may be of intra- and/or supra-spinal origin

Quantum Mechanics Model on K\"ahler conifold

We propose an exactly-solvable model of the quantum oscillator on the class of K\"ahler spaces (with conic singularities), connected with two-dimensional complex projective spaces. Its energy spectrum is nondegenerate in the orbital quantum number, when the space has non-constant curvature. We reduce the model to a three-dimensional system interacting with the Dirac monopole. Owing to noncommutativity of the reduction and quantization procedures, the Hamiltonian of the reduced system gets non-trivial quantum corrections. We transform the reduced system into a MIC-Kepler-like one and find that quantum corrections arise only in its energy and coupling constant. We present the exact spectrum of the generalized MIC-Kepler system. The one-(complex) dimensional analog of the suggested model is formulated on the Riemann surface over the complex projective plane and could be interpreted as a system with fractional spin.Comment: 5 pages, RevTeX format, some misprints heve been correcte