Evaluation of the Efficacy of Curcumin in Experimentally Induced Acute Otitis Media in Rats

WOS: 000335494400004PubMed: 24642584Objectives: We investigated the effect of curcumin (CMN) in the treatment of experimentally induced acute otitis media (AOM) in rats. Method: Thirty-two Sprague-Dawley female rats were used, yielding 64 temporal bones. Group 1 was the control group. For groups 2 to 4, AOM was induced experimentally, and saline, antibiotics (sulbactam-ampicillin), or CMN were administered for 14 days to groups 2, 3, and 4, respectively. During the histological examination, thickening of the tympanic membrane, damage to the epithelium, inflammation, and sclerosis were evaluated. Results: The AOM+antibiotic and AOM+CMN groups exhibited reduced histological damage compared with the AOM+saline group. No significant differences in thickening of the tympanic membrane or damage to the epithelium or inflammation were observed between the AOM+antibiotic and the AOM+CMN groups. However, the sclerosis values of the AOM+CMN group were significantly lower than those of the AOM+antibiotic group. Conclusion: CMN treatment resulted in similar effects on the experimentally induced AOM model as did the antibiotic treatment. The efficacy of this treatment may be related to its effects on the production of various inflammatory cytokines. In light of the worldwide increase in antibiotic resistance and the mild side effects of CMN, we suggest that CMN therapy may be a promising option in AOM treatment

Why some memories do not last a lifetime: dynamic long-term retrieval in changing environments

Memory is a fundamental component of learning, a process by which individuals alter their behavior through experience. Although memory most likely has explicit costs such as synaptic maintenance and metabolic demands, there are also implicit costs to memory, in particular, the use of information that is no longer appropriate or is incorrect. Specifically, the period of retrievability for memories, or "memory window," should be sensitive to the rate of environmental change of information stored in memory. Much empirical data suggest that memory length--this period of retrievability--changes with both the age and state of the individual. Here, we use a dynamic programming approach to examine how optimal memory retrieval might change within the lifetime of the individual learner. We find that optimal memory length varies with both age and state (e.g., energy reserves) of the organism and that features of the environment determine how this change in memory occurs. In our model, retrieval decreases as the environment becomes unreliable but roughly increases with the cost of living. Cost of living interacts with the state of the organism: with high cost of living, an organism in a very poor state should have a long memory length, but an organism in a very good state with low costs of living should have a short memory length. Finally, we find there are circumstances where it is optimal for memory retrieval to decline toward the end of the lifetime. Because this framework does not incorporate inevitable degradation of neural mechanisms, this result implies that memory loss with age might actually be adaptive. Copyright 2009, Oxford University Press.