Down South, Up North's business plan

The following is the business plan for my new restaurant, "Down South, Up North." This restaurant will serve the DeKalb and Sycamore community, not only as a restaurant but as a breeding ground and/or stepping stone for aspiring entrepreneurs.B.S. (Bachelor of Science

Pulsars in FIRST Observations

We identified 16 pulsars from the Faint Images of the Radio Sky at Twenty-cm (FIRST) at 1.4 GHz. Their positions and total flux densities are extracted from the FIRST catalog. Comparing the source positions with those in the PSRcatalog, we obtained better determined positions of PSRs J1022+1001, J1518+4904, J1652+2651, and proper motion upper limits of another three pulsars PSRs J0751+1807, J1012+5307, J1640+2224. Proper motions of the other 10 pulsars are consistent with the values in the catalog.Comment: 6 pages, 2 figures, 3 tables, submited to CJA

Dynamical Model of Coherent Pion Production in Neutrino-Nucleus Scattering

We study coherent pion production in neutrino-nucleus scattering in the energy region relevant to neutrino oscillation experiments of current interest. Our approach is based on a combined use of the Sato-Lee model of electroweak pion production on a nucleon and the Delta-hole model of pion-nucleus reactions. Thus we develop a model which describes pion-nucleus scattering and electroweak coherent pion production in a unified manner. Numerical calculations are carried out for the case of the 12C target. All the free parameters in our model are fixed by fitting to both total and elastic differential cross sections for pi-12C scattering. Then we demonstrate the reliability of our approach by confronting our prediction for the coherent pion photo-productions with data. Finally, we calculate total and differential cross sections for neutrino-induced coherent pion production, and some of the results are (will be) compared with the recent (forthcoming) data from K2K, SciBooNE and MiniBooNE. We also study effect of the non-locality of the Delta-propagation in the nucleus, and compare the elementary amplitudes used in different microscopic calculations.Comment: 42 pages, 21 figure

NH3 in the Central 10 pc of the Galaxy. II. Determination of Opacity for Gas with Large Linewidths

The 23 GHz emission lines from the NH3 rotation inversion transitions are widely used to investigate the kinematics and physical conditions in dense molecular clouds. The line profile is composed of hyperfine components which can be used to calculate the opacity of the gas (Ho & Townes 1983). If the intrinsic linewidth of the gas exceeds one half of the separation of these quadrupole hyperfine components (~5-10 km/s) these lines blend together and the observed linewidths greatly overestimate the intrinsic linewidths. If uncorrected, these artificially broad linewidths will lead to artificially high opacities. We have observed this effect in our NH3 data from the central 10 pc of the Galaxy where uncorrected NH3 (1,1) linewidths of ~30 km/s exaggerate the intrinsic linewidths by more than a factor of two (Genzel & Townes 1987). Models of the effect of blending on the line profile enable us to solve for the intrinsic linewidth and opacity of NH3 using the observed linewidth and intensity of two NH3 rotation inversion transitions. We present the result of the application of this method to our Galactic Center data. We successfully recover the intrinsic linewidth and opacity of the gas. Clouds close to the nucleus in projected distance as well as those that are being impacted by Sgr A East show the highest intrinsic linewidths. The cores of the ``southern streamer'' (Ho et al. 1991; Coil & Ho 1999, 2000) and the ``50 km/s'' giant molecular cloud have the highest opacities.Comment: 27 pages, 10 figures, accepted for publication in Ap

NH3 in the Central 10 pc of the Galaxy I: General Morphology and Kinematic Connections Between the CND and GMCs

New VLA images of NH3 (1,1), (2,2), and (3,3) emission in the central 10 parsecs of the Galaxy trace filamentary streams of gas, several of which appear to feed the circumnuclear disk (CND). The NH3 images have a spatial resolution of 16.5''x14.5'' and have better spatial sampling than previous NH3 observations. The images show the ``southern streamer,'' ``50 km/s cloud,'' and new features including a ``western streamer'', 6 parsecs in length, and a ``northern ridge'' which connects to the CND. NH3(3,3) emission is very similar to 1.2 mm dust emission indicating that NH3 traces column density well. Ratios of the NH3(2,2) to (1,1) line intensities give an estimate of the temperature of the gas and indicate high temperatures close to the nucleus and CND. The new data cover a velocity range of 270 km/s, including all velocities observed in the CND, with a resolution of 9.8 km/s. Previous NH3 observations with higher resolution did not cover the entire range of velocities seen in the CND. The large-scale kinematics of the CND do not resemble a coherent ring or disk. We see evidence for a high velocity cloud within a projected distance of 50'' (2 pc) which is only seen in NH3(3,3) and is likely to be hot. Comparison to 6 cm continuum emission reveals that much of the NH3 emission traces the outer edges of Sgr A East and was probably pushed outward by this expanding shell. The connection between the northern ridge (which appears to be swept up by Sgr A East) and the CND indicates that Sgr A East and the CND are in close proximity to each other. Kinematic evidence for these connections is presented in this paper, while the full kinematic analysis of the central 10 pc will be presented in Paper II.Comment: 16 pages (containing 6 figures), 8 additional JPEG figures. Accepted for publication in ApJ. For full resolution images, see http://cfa-www.harvard.edu/~rmcgary/SGRA/nh3_figures.htm

Molecular Tracers of the Central 12 pc of the Galactic Center

We have used the BIMA array to image the Galactic Center with a 19-pointing mosaic in HCN(1-0), HCO+(1-0), and H 42-alpha emission with 5 km/s velocity resolution and 13'' x 4'' angular resolution. The 5' field includes the circumnuclear ring (CND) and parts of the 20 and 50 km/s clouds. HCN(1-0) and HCO+ trace the CND and nearby giant molecular clouds while the H 42-alpha emission traces the ionized gas in Sgr A West. We find that the CND has a definite outer edge in HCN and HCO+ emission at ~45'' radius and appears to be composed of two or three distinct streams of molecular gas rotating around the nucleus. Outside the CND, HCN and HCO+ trace dense clumps of high-velocity gas in addition to optically thick emission from the 20 and 50 km/s clouds. A molecular ridge of compressed gas and dust, traced in NH3 emission and self-absorbed HCN and HCO+, wraps around the eastern edge of Sgr A East. Just inside this ridge are several arcs of gas which have been accelerated by the impact of Sgr A East with the 50 km/s cloud. HCN and HCO+ emission trace the extension of the northern arm of Sgr A West which appears to be an independent stream of neutral and ionized gas and dust originating outside the CND. Broad line widths and OH maser emission mark the intersection of the northern arm and the CND. Comparison to previous NH3 and 1.2mm dust observations shows that HCN and HCO+ preferentially trace the CND and are weaker tracers of the GMCs than NH3 and dust. We discuss possible scenarios for the emission mechanisms and environment at the Galactic center which could explain the differences in these images.Comment: 24 pages, including 17 figures; to appear in The Astrophysical Journa

SWOG S1400C (NCT02154490)-A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy).

ObjectiveLung-MAP (SWOG S1400) is a master platform trial assessing targeted therapies in squamous NSCLC. The objective of study C (S1400C) was to evaluate the response rate to palbociclib, a cyclin-dependent kinase 4 and cyclin-dependent kinase 6 inhibitor, in patients with cell cycle gene abnormalities.MethodsPatients with squamous NSCLC, a performance status of 0 to 2, and normal organ function who had progressed after at least one prior platinum-based chemotherapy with cyclin-dependent kinase 4 gene (CDK4) or cyclin D1 gene (CCND1), cyclin D2 gene (CCND2), or cyclin D3 gene (CCND3) amplifications on tumor specimens were eligible. The study was originally designed as a phase II/III trial comparing palbociclib with docetaxel, but it was modified to a single-arm phase II trial with the primary end point of response when immunotherapy was approved. If two or fewer responses were seen in the first 20 patients, then the study would cease enrollment.ResultsA total of 88 patients (9% of patients screened) were assigned to S1400C, and 53 patients enrolled (including 17 to receive docetaxel). One patient who had been registered to receive docetaxel was re-registered to receive palbociclib after progression while taking docetaxel. The frequencies of cell cycle gene alterations in the eligible patients taking palbociclib (n = 32) were as follows: CCND1, 81% (n = 26); CCND2, 9% (n = 3); CCND3, 6% (n = 2); and CDK4, 3% (n = 1). In all, 32 eligible patients received palbociclib. There were two partial responses (response rate 6% [95% confidence interval (CI): 0%-15%]), both with CCND1 amplification. Twelve patients had stable disease (38% [95% CI: 21%-54%]). The median progression-free survival was 1.7 months (95% CI: 1.6-2.9 months) and the median overall survival was 7.1 months (95% CI: 4.2-12.5).ConclusionPalbociclib as monotherapy failed to demonstrate the prespecified criteria for advancement to phase III testing

Defining forgiveness: Christian clergy and general population perspectives.

The lack of any consensual definition of forgiveness is a serious weakness in the research literature (McCullough, Pargament &amp; Thoresen, 2000). As forgiveness is at the core of Christianity, this study returns to the Christian source of the concept to explore the meaning of forgiveness for practicing Christian clergy. Comparisons are made with a general population sample and social science definitions of forgiveness to ensure that a shared meaning of forgiveness is articulated. Anglican and Roman Catholic clergy (N = 209) and a general population sample (N = 159) completed a postal questionnaire about forgiveness. There is agreement on the existence of individual differences in forgiveness. Clergy and the general population perceive reconciliation as necessary for forgiveness while there is no consensus within psychology. The clergy suggests that forgiveness is limitless and that repentance is unnecessary while the general population suggests that there are limits and that repentance is necessary. Psychological definitions do not conceptualize repentance as necessary for forgiveness and the question of limits has not been addressed although within therapy the implicit assumption is that forgiveness is limitless.</p