165 research outputs found

    A Comment on the WHO Classification of Salivary Gland Tumors

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    Creation operators and algebraic Bethe ansatz for the elliptic quantum group Eτ,η(so3)E_{\tau,\eta}(so_3)

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    We define the elliptic quantum group Eτ,η(so3)E_{\tau,\eta}(so_3) and the transfer matrix corresponding to its simplest highest weight representation. We use Bethe anstaz method to construct the creation operators as polynomials of the Lax matrix elements expressed through a recurrence relation. We give common eigenvectors and eigenvalues of the family of commuting transfer matrices.Comment: 13 page

    Изоловање и антимикробна активност антрахинона неких врста лишајева рода Xanthoria

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    The isolation of six anthraquinones erythroglaucin, physcion, xanthorin, emodin, fallacinal, teloschistin, from three species of the lichen genus Xanthoria (X.fallax, X.elegans and X.policarpa) is reported. Physcion is the dominant anthraquinone in all species.The anthraquinones showed broad-spectrum and fungal and selective activity against some phytopathogenic bacterial species.Из три врсте лишајева рода Xanthoriа (X.fallax, X.elegans and X.policarpa) изоловани су следећи антрахинони : еритроглауцин, фисцион, ксанторин, емодин, фалацинал и фалацинол.Тестирани антрахинони показују широк спектар антифунгалне активности и селективну активност према неким врстама фитопатогених бактерија

    The isolation, analytical characterization by HPLC-UV and NMR spectroscopy, cytotoxic and antioxidant activities of baeomycesic acid from Thamnolia vermicularis var. subuliformis

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    The aim of this work was the analytical characterization of the β-orcinol depside, baeomycesic acid in lichens extracts. The extract of Thamnolia vermicularis var. subuliformis was analyzed by the two different methods, namely HPLC-UV and 1H NMR analysis. The results showed that baeomycesic acid was the most abundant depside in the lichens. These results could be of use for rapid identification of this metabolite in other lichen species. Besides baeomycesic acid, three depsides and one monocyclic phenolic compound were isolated from the lichen extract on the chromatographic column. The structure of baeomycesic acid was confirmed by HPLC-UV and spectroscopic methods. In addition, antioxidant and cytotoxic activities of baeomycesic acid were determined. The result of the testing showed that baeomycesic acid exhibited a moderate radical scavenging activity (IC50 = 602.10 ± 0.54 μg/mL) and good cytotoxic activity. This is the first report of detailed analytical characterization, isolation, as well as antioxidant and cytotoxic activities of baeomycesic acid from Thamnolia vermicularis. These results may be helpful in future industrial production of herbal medicines that include this important natural product

    Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

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    The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex- and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis
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