A clinical study to evaluate the efficacy of Khaakhasadi Lepa in Padadari (Crack Heel)

Padadari = Pada + Dari. Padadari is one among Kshudra Rogas. Sushruta, Madhavnidana and Bhavprakasha has explained Padadari as distinct disease. In modern, it is termed as crack heel. Padadari is a Vatapradhana Vyadhi. Vataprakopa leads to the symptoms as Padasputana, Vedana, Rukshata and Daha. Atichankramana and Vataprakopaka Ahara and Vihara are the main cause for Padadari. Khaakhasadi Lepa has Vatahara, Vranashodhaka, Vranaropaka, Twagdoshahara, Kandughna properties which helps in Samprapti Vighatana of Padadari. The study is attempt to clinically analyze the efficacy of Khakhasadi Lepa indendently and compare with Moisturex cream in Padadari. This study is a randomized single blind standared control clinical study conducted on 60 subjects divided randomly in two groups. Group A (Trial group) and Group B (Control group) were formed with 30 patients in each group. Group A was treated with Khaakhasadi Lepa for one month. Group B was treated with Moisturex cream for one month. Lepa was adviced to apply in night on affected area of sole in quantity sufficient. Cleaning of sole and after proper drying, application of lepa was advised.The patients were assessed with severity of symptoms subjectively before and after treatment. Data from each group is statistically analyzed and compared. Both the group showed marked results but Khaakhasadi Lepa showed statistically highly significant result in subjective parameter like Vedana and Rukshata. Khakhasadi Lepa is not that much significant in Padasputana as compare to Moisturex cream. The study shows that Khaakhasadi Lepa and Moisturex cream had got equally significant relief in Vedana and Rukshata. Both drugs were insignificant in reducing Daha. Khakhasadi Lepa was not more effective in Padasputana

CONTROLLED RELEASE OF GABAPENTIN THROUGH RETICULATED CHITOSAN AND HYDROXYETHYL CELLULOSE HYDROGEL MATRIX TABLETS

The aim of the present work was to prepare hydrogel matrix tablets using crosslinked chitosan and hydroxyethyl cellulose (HEC) for controlled release of gabapentin. The chitosan was crosslinked with acetaldehyde and used for the preparation of hydrogel matrix tablets along with hydroxylethyl cellulose by wet granulation method. The samples were characterized by FTIR, DSC, TGA, XRD, SEM and evaluated drug content, swelling pattern and drug release. The matrix tablets were capable of releasing the drug for 24h depending upon the formulation variables. It was observed that as the concentration of HEC increased in the tablets, the drug release was also increased. On the other hand, as the crosslinking of chitosan was increased, the drug release was decreased. Drug release mechanism followed non-Fickian transport. This study demonstrated that the blend hydrogel matrix tablets of crosslinked chitosan and HEC could be a versatile drug delivery system for controlled release of gabapentin

Anatomy‐based diagnostic criteria for complex body wall anomalies (CBWA)

Abstract Background Precise diagnosis and classification of CBWA cases can be challenging. BSA are considered when there is a body wall anomaly, skeletal abnormalities, and the umbilical cord is anomalous, absent or rudimentary, and LBWC when there is a body wall and structural limb anomalies with or without craniofacial abnormalities. Methods PubMed was searched for body stalk anomalies, limb body wall complex, body stalk anomalies and amniotic band syndrome, and limb body wall complex and amniotic band syndrome. Sixty nine articles were selected and reviewed. This article systematically classifies the variants of CBWA in 218 cases, the study is based on the embryological and anatomical criteria established by Martín‐Alguacil and Avedillo to study BSA in the pig. Results Eight different BSA presentation were defined. One hundred and eighty nine cases were classified as BSA, from which five were Type I, nine Type II, 20 Type III, 57 Type IV, 11Type V, 24 Type VI, 11 Type VII, and 52 Type VIII. Twenty six cases presented cranial phenotype, 114 abdominal phenotype, 42 cranio/abdominal overlapping phenotype, and five without defined phenotype. In addition, 52 BSA cases presented some kind of spinal dysraphism (SPDYS) and were classified as BSA/SPDYS, most of these cases did not show structural limb anomalies, except for three cases and were classified as LBWC/SPDYS. Conclusion This morphology‐based classification represents a useful tool for clinical diagnosis, it helps to quantify and to evaluate CBWA in a precise, objective manner