The PTA: Promoting Swiss Tours, 1888-1939

This research examines the development from educational to commercial tourism in Britain between the late-nineteenth and early-twentieth century by questioning whether this reflected a transformed understanding of the role of travel within society. It focuses on the Polytechnic Touring Association (PTA), a London-based originally philanthropic travel organisation that became a commercial firm. During this period the PTA moved from the project of contributing to the education of citizens to the market-led imperative of ‘harnessing’ a consumer desire. In examining this transformation via the PTA’s changing approach to the visual promotion of its Swiss tours, we suggest that the development of the tourism industry in Britain should also be explored in relation to changing ideas about travel’s contribution to social formation

An Investigation of the Effectiveness of Training in the Utilization of Spiritual Gifts in the Personal Ministries of Ontario Seventh-day Adventists

Problem. The New Testament indicates that spiritual gifts occupy a crucial function in the life and growth of the church. No known empirical study has measured the effectiveness of nurture and training for gift implementation. This study was designed to investigate behavioral change in awareness and use of spiritual gifts by Seventh-day Adventist members. Methodology. The New spiritual Gifts Inventory (NSGI) was used to identify awareness of giftedness in five clusters--Teaching, Shepherding-Evangelizing, Supporting, Counseling, and Leadership. An Activity Inventory was developed for the study with 20 activity questions corresponding to the NSGI. The following statistical designs were used to analyze the data: Paired samples t-test to discover changes in subjects; one-way analysis of covariance to analyze the difference between the experimental and control groups in giftedness and activities; two-way analysis of covariance to investigate the presence of interactions between the treatment and personal values affecting spiritual gifts and activity factors. Seventy-two subjects participated in the study. The experimental group of 40 subjects was randomly selected from one West Indian (Black)congregation and one Caucasian (non-Black) congregation. The control group comprised of 32 subjects, was randomly chosen from one West Indian congregation and one Caucasian congregation. Results. Qualitatively, subjects sensed their need to use their gifts in the church as a function of their ministry. Quantitatively, treatment produced significant increases in gift awareness in the experimental group in the factors Counseling (p = .01) and Leadership (p = .00). Five experimental sub-groups whose pre-test were not primary, improved significantly in Shepherding-Evangelizing, Supporting, and Leadership awareness, and in Teaching and Shepherding-Evangelizing activities. No significant interactions were evident between the treatment and personal factors affecting gifts and activities except that Blacks increased more in counseling activities than Non-Blacks (p = .05) after the treatment. The Hawthorne effect was sufficient to produce significant increases in the control subjects\u27 activities. Conclusions. Nurture and training increased awareness of spiritual gifts in Seventh-day Adventists in Ontario. A study of spiritual gifts with suggested activities can sensitize believers to significant involvement in personal ministries. It also seems evident that gifts are generally distributed without bias, but Blacks improve in more counseling and caring activities than non-Blacks

Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital, Kenya

<p>Abstract</p> <p>Background</p> <p>Severe anaemia is a common cause for hospitalization in children in sub-Saharan Africa. Malaria plays an important aetiological role, resulting in a substantial burden of paediatric transfusion in hospitals. A decline in malaria and paediatric admissions to the Kilifi District Hospital has been reported recently. This study aimed to investigate whether this trend affected clinical burden, clinical severity of anaemia and requirements for paediatric transfusion.</p> <p>Methods</p> <p>Eight-year retrospective review of paediatric admissions to Kilifi District Hospital, Kenya describing the frequency of moderate and severe anaemia, blood transfusion and case fatality over time. Definitions for severe anaemia were Hb <8 g/dl for newborns and <5 g/dl for other age groups and for moderate anaemia was Hb 8 to <11 g/dl for newborns and 5 to <9.3 g/dl for other age groups. Life threatening anaemia was defined as severe anaemia (Hb <5 g/dl) complicated by either deep breathing or prostration or profound anaemia (Hb <4 g/dl) alone.</p> <p>Results</p> <p>Of the 35,139 admissions 13,037 (37%) had moderate anaemia and 2,265 (6%) had severe anaemia; respiratory distress complicated 35% of cases with Hb <5 g/dl. Concurrent with the decline in malaria there was a marked decline in the prevalence of severe anaemia between 2002 (8%) and 2009 (< 4%) (chi²for trend = 134, P < 0.0001). The number and proportion of admissions transfused also declined significantly over this time (chi2 for trend = 152, P < 0.0001). Of the 2,265 children with severe anaemia 191 (8%) died. Case fatality remained unchanged during this period (P < 0.26) and was largely explained by the unchanged proportion with life-threatening anaemia, present in 58-65% of cases throughout the study period.</p> <p>Conclusion</p> <p>The impact of reduced malaria transmission on child morbidity has positive public benefits on the demand and use of blood for paediatric transfusion. Despite an overall reduction in paediatric transfusion requirement, case fatality of severe anaemia remained unchanged over this decade. Further research is required to improve outcome from severe anaemia, particularly in the high-risk group with life threatening features.</p

Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis

In comparison to more differentiated cells, prostate cancer stem-like cells are radioresistant, which could explain radio-recurrent prostate cancer. Improvement of radiotherapeutic efficacy may therefore require combination therapy. We have investigated the consequences of treating primary prostate epithelial cells with gamma irradiation and photodynamic therapy (PDT), both of which act through production of reactive oxygen species (ROS). Primary prostate epithelial cells were cultured from patient samples of benign prostatic hyperplasia and prostate cancer prior to treatment with PDT or gamma irradiation. Cell viability was measured using MTT and alamar blue assay, and cell recovery by colony-forming assays. Immunofluorescence of gamma-H2AX foci was used to quantify DNA damage, and autophagy and apoptosis were assessed using Western blots. Necrosis and senescence were measured by propidium iodide staining and beta-galactosidase staining, respectively. Both PDT and gamma irradiation reduced the colony-forming ability of primary prostate epithelial cells. PDT reduced the viability of all types of cells in the cultures, including stem-like cells and more differentiated cells. PDT induced necrosis and autophagy, whereas gamma irradiation induced senescence, but neither treatment induced apoptosis. PDT and gamma irradiation therefore inhibit cell growth by different mechanisms. We suggest these treatments would be suitable for use in combination as sequential treatments against prostate cancer

In vitro modelling of epithelial and stromal interactions in non-malignant and malignant prostates

To study the effects of stromal epithelial cell interactions on prostate cancer metastasis, we have used primary human prostatic stromal cells derived from malignant and non-malignant tissues and established epithelial cell lines from normal (PNT1a and PNT2-C2) and tumour (PC-3, DU145 and LNCaP) origins. The effects of stromal cells on epithelial cell growth were studied in direct and indirect (using culture inserts) co-culture and by exposure to stromal cell-conditioned medium (assessed by MTT assay). The influence of stromal cells on epithelial cell invasion was measured using matrigel invasion chambers and on epithelial cell motility using time lapse microscopy. Results indicated that epithelial cell line growth was similarly unaffected or inhibited by stromal cells derived from malignant (n = 8) or non-malignant tissue (n = 8). In contrast, PNT2-C2 and PC-3 cells were found to be the least and the most invasive and motile epithelia respectively. Stromal cultures enhanced the invasion of both epithelial cells, but no differences were observed between the use of malignant and non-malignant tissues. All stromal cultures modestly stimulated PNT2-C2 motility but displayed a greater stimulation of PC-3 cell motility, while stromal cells derived from malignant tissue stimulated PNT2-C2 and PC-3 cell motility more than stromal cultures from non-malignant tissues. © 2000 Cancer Research Campaig