The Poker Face of Inelastic Dark Matter: Prospects at Upcoming Direct Detection Experiments

The XENON100 and CRESST experiments will directly test the inelastic dark matter explanation for DAMA's 8.9? sigma anomaly. This article discusses how predictions for direct detection experiments depend on uncertainties in quenching factor measurements, the dark matter interaction with the Standard Model and the halo velocity distribution. When these uncertainties are accounted for, an order of magnitude variation is found in the number of expected events at CRESST and XENON100.Comment: 5 pages, 3 figure

Direct Detection of Dark Matter Debris Flows

Tidal stripping of dark matter from subhalos falling into the Milky Way produces narrow, cold tidal streams as well as more spatially extended "debris flows" in the form of shells, sheets, and plumes. Here we focus on the debris flow in the Via Lactea II simulation, and show that this incompletely phase-mixed material exhibits distinctive high velocity behavior. Unlike tidal streams, which may not necessarily intersect the Earth's location, debris flow is spatially uniform at 8 kpc and thus guaranteed to be present in the dark matter flux incident on direct detection experiments. At Earth-frame speeds greater than 450 km/s, debris flow comprises more than half of the dark matter at the Sun's location, and up to 80% at even higher speeds. Therefore, debris flow is most important for experiments that are particularly sensitive to the high speed tail of the dark matter distribution, such as searches for light or inelastic dark matter or experiments with directional sensitivity. We show that debris flow yields a distinctive recoil energy spectrum and a broadening of the distribution of incidence direction.Comment: 22 pages, 7 figures; accepted for publication in PR

High Multiplicity Searches at the LHC Using Jet Masses

This article introduces a new class of searches for physics beyond the Standard Model that improves the sensitivity to signals with high jet multiplicity. The proposed searches gain access to high multiplicity signals by reclustering events into large-radius, or "fat," jets and by requiring that each event has multiple massive jets. This technique is applied to supersymmetric scenarios in which gluinos are pair-produced and then subsequently decay to final states with either moderate quantities of missing energy or final states without missing energy. In each of these scenarios, the use of jet mass improves the estimated reach in gluino mass by 20 % to 50 % over current LHC searches.Comment: 9 pages, 6 figures; v3 corrects a few small typo

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin

High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to effects on cellular energy metabolism. Since tumour hypoxia and glucose availability are major cellular redox determinants, we evaluated their role in endometrial cancer response to metformin. Endometrial cancer biopsies from women treated with pre-surgical metformin were tested for the hypoxia markers, HIF-1α and CA-9. Endometrial cancer cell lines were treated with metformin in variable glucose concentrations in normoxia or hypoxia and cell viability, mitochondrial biogenesis, function and energy metabolism were assessed. In women treated with metformin (n = 28), Ki-67 response was lower in hypoxic tumours. Metformin showed minimal cytostatic effects towards Ishikawa and HEC1A cells in conventional medium (25 mM glucose). In low glucose (5.5 mM), a dose-dependent cytostatic effect was observed in normoxia but attenuated in hypoxia. Tumours treated with metformin showed increased mitochondrial mass (n = 25), while in cultured cells metformin decreased mitochondrial function. Metformin targets mitochondrial respiration, however, in hypoxic, high glucose conditions, there was a switch to glycolytic metabolism and decreased metformin response. Understanding the metabolic adaptations of endometrial tumours may identify patients likely to derive clinical benefit from metformin

The Dark Matter at the End of the Galaxy

Dark matter density profiles based upon Lambda-CDM cosmology motivate an ansatz velocity distribution function with fewer high velocity particles than the Maxwell-Boltzmann distribution or proposed variants. The high velocity tail of the distribution is determined by the outer slope of the dark matter halo, the large radius behavior of the Galactic dark matter density. N-body simulations of Galactic halos reproduce the high velocity behavior of this ansatz. Predictions for direct detection rates are dramatically affected for models where the threshold scattering velocity is within 30% of the escape velocity.Comment: 10 pages, 5 figure

A Keplerian Disk around the Herbig Ae star HD169142

We present Submillimeter Array observations of the Herbig Ae star HD169142 in 1.3 millimeter continuum emission and 12CO J=2-1 line emission at 1.5 arcsecond resolution that reveal a circumstellar disk. The continuum emission is centered on the star position and resolved, and provides a mass estimate of about 0.02 solar masses for the disk. The CO images show patterns in position and velocity that are well matched by a disk in Keplerian rotation with low inclination to the line-of-sight. We use radiative transfer calculations based on a flared, passive disk model to constrain the disk parameters by comparison to the spectral line emission. The derived disk radius is 235 AU, and the inclination is 13 degrees. The model also necessitates modest depletion of the CO molecules, similar to that found in Keplerian disks around T Tauri stars.Comment: 10 pages, 2 figures, accepted by A

Essential role of STAT5a in DCIS formation and invasion following estrogen treatment

Ductal carcinoma in situ (DCIS) is one of the earliest stages of breast cancer (BCa). The mechanisms by which DCIS lesions progress to an invasive state while others remain indolent are yet to be fully characterized and both diagnosis and treatment of this pre-invasive disease could benefit from better understanding the pathways involved. While a decreased expression of Caveolin-1 (Cav-1) in the tumor microenvironment of patients with DCIS breast cancer was linked to progression to invasive breast cancer (IBC), the downstream effector(s) contributing to this process remain elusive. The current report shows elevated expression of Signal Transducer and Activator of Transcription 5a (STAT5a) within the DCIS-like lesions in Cav-1 KO mice following estrogen treatment and inhibition of STAT5a expression prevented the formation of these mammary lesions. In addition, STAT5a overexpression in a human DCIS cell line (MCF10DCIS.com) promoted their invasion, a process accelerated by estrogen treatment and associated with increased levels of the matrix metalloproteinase-9 (MMP-9) precursor. In sum, our results demonstrate a novel regulatory axis (Cav-1♦STAT5a♦MMP-9) in DCIS that is fully activated by the presence of estrogen. Our studies suggest to further study phosphorylated STAT5a (Y694) as a potential biomarker to guide and predict outcome of DCIS patient population

Singlet fermionic dark matter

We propose a renormalizable model of a fermionic dark matter by introducing a gauge singlet Dirac fermion and a real singlet scalar. The bridges between the singlet sector and the standard model sector are only the singlet scalar interaction terms with the standard model Higgs field. The singlet fermion couples to the standard model particles through the mixing between the standard model Higgs and singlet scalar and is naturally a weakly interacting massive particle (WIMP). The measured relic abundance can be explained by the singlet fermionic dark matter as the WIMP within this model. Collider implication of the singlet fermionic dark matter is also discussed. Predicted is the elastic scattering cross section of the singlet fermion into target nuclei for a direct detection of the dark matter. Search of the direct detection of the dark matter provides severe constraints on the parameters of our model.Comment: 12 pages, 7 figure