AYURVEDIC MANAGEMENT OF POLYCYSTIC OVARIAN SYNDROME BY PALASADI BASTI AND PATHADI CHOORNA: A CASE REPORT

Polycystic Ovarian Syndrome is the most common disease in the female population among adolescence and reproductive age group mainly due to the adoption of westernized culture. Polycystic Ovarian Syndrome (PCOS) is a physiological disorder that causes many negative effects involving a variety of systems in the body, such as the endocrine, metabolic, psychological, and reproductive systems. The complex symptomatology of PCOS makes very difficult to treat as a whole. In Ayurveda also no disease can be compared directly with PCOS. Some of clinical symptoms of PCOS may simulate Granthibhoota Artava dushti and if not treated early lead to the full manifestations and complications of PCOS. A 26 year old female came to OPD of Streeroga of IPGT & RA, having the complaints of irregular cycle, weight gain and failure to conceive since 2 years of active married life with a previous history of abortion. Sonography revealed bulky ovaries with multiple small follicles. Based on clinical findings along with sonological evidences Polycystic Ovarian Syndrome was diagnosed and a treatment protocol was selected for managing the PCOS and finally to achieve conception. Palasadi basti was selected followed by Pathadi choorna orally with warm water as internal medicine. The treatment was done for 3 months and during follow up the cycles became regular and finally the patient got conceived within 2 months

Evolutionary behaviour of cosmological parameters with dynamical system analysis in f (Q, T) gravity

We have investigated the accelerating behaviour of the universe in $f(Q,T)$ gravity in an isotropic and homogeneous space-time. We have initially derive the dynamical parameters in the general form of $f(Q,T)=\alpha Q^{m}+\beta T$ [Xu et al., Eur. Phys. J. C, \textbf{79}, 708 (2019)] and then split it into two cases (i) one with $m=1$ and the (ii) other with $\beta=0$. In the first case, it reduces to the linear form of the functional $f(Q,T)$ and second case leads to the higher power of the nonmetricity $Q$. In an assumed form of the hyperbolic scale factor, the models are constructed and its evolutionary behaviours are studied. The geometrical parameters as well the equation of state parameter are obtained and found to be in the preferred range of the cosmological observations. Marginal variation has been noticed in the behaviour of $\omega$ and $\omega_{eff}$ at present time. The violation of strong energy conditions in both the cases are shown. The dynamical system analysis for the models has been performed.Comment: 17 pages, 8 figure

Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model

This is a preliminary study that explores the efficacy of Aloe vera gel formulation as a possible therapeutic agent in the prevention and management of polycystic ovary syndrome (PCOS). PCOS is recognized as the most common endocrinopathy of women. Increased androgen synthesis, disrupted folliculogenesis, and insulin resistance lie at the patho-physiological core of PCOS. Current therapy for such a syndrome is use of insulin sensitizers. Large randomized clinical trials of metformin as the insulin-sensitizing drug, however, suggested that it produces many side effects after prolonged usage. For this reason, an alternate therapy would be to use herbs with hypoglycemic potential. Aloe barbadensis Mill. (Liliaceae) popularly known as Aloe vera is a well-known plant with such properties. The present study evaluated the efficacy of Aloe vera gel formulation in a PCOS rat model. Five month old Charles Foster female rats were orally fed with letrozole, a non-steroidal aromatase inhibitor, to induce PCOS. The rats were then treated orally with the Aloe vera gel formulation (1 ml dose daily for 45 days). This restored their estrus cyclicity, glucose sensitivity, and steroidogenic activity. Co-treatment of the inductive agent (letrozole) with the Aloe vera gel prevented the development of the PCO phenotype. Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by restoring the ovarian steroid status, and altering key steroidogenic activity. This can be attributed to phyto-components present in the extract

Familial relationship and its impact on the psyche of transgenders: A study of The Truth About Me by Revathi

Modern society is evolving each day, technologically, socially, and economically. Nevertheless, society marginalizes people based on their gender, caste, sex, etc., and transgenders stand on the gruesome end of this line. Even though transgenders have become part of the active phase of contemporary society, they are often segregated by the name ‘transgender.’ Gender identity is always a major issue in the thick and thin of society. They are also termed as people of the third gender. Still, people believe that transgenders are sex workers or they were born cursed. So, they disappear from the active phase of society. The public’s attitude toward transgenders is like untouchables and they taunt them without any humanity, putting them to the status of animals living in the streets. They earn a livelihood through sex work and begging. This is portrayed by Revathi in her autobiography, The Truth About Me: A Hijra Life Story. The paper attempts an analysis of how family plays a significant role in their acceptance in society. Almost all of them face issues emanating from the childhood traumas they experience.&nbsp

Proteomic profiling of forskolin-induced differentiated BeWo cells: an in-vitro model of cytotrophoblast differentiation

Placental trophoblastic differentiation is characterized by the fusion of monolayer cytotrophoblasts into syncytiotrophoblasts. During this process of differentiation, several morphological and biochemical changes are known to occur, and this model has been employed to investigate the changes that occur at the gene and protein level during differentiation. Using the sensitive technique of proteomics [two-dimensional gel electrophoresis (2DGE)], changes in protein profile were evaluated in the control and forskolin-induced differentiated cells of trophoblastic choriocarcinoma BeWo cell line. Several proteins were differentially expressed in control and differentiated cells. Four major proteins were up-regulated as assessed by silver staining, and were further characterized as c-h-ras p 21 (phosphorylated), retinoblastoma susceptibility protein 1 and integrase interactor protein 1. These proteins are known to play an important role in growth arrest of cells, and thus may play a role in initiating the process of differentiation