307 research outputs found
Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring
The effect of moderate intensity exercise in the postprandial period on the inflammatory response to a high-fat meal: an experimental study
Citation: Teeman, C. S., Kurti, S. P., Cull, B. J., Emerson, S. R., Haub, M. D., & Rosenkranz, S. K. (2016). The effect of moderate intensity exercise in the postprandial period on the inflammatory response to a high-fat meal: an experimental study. Nutrition Journal, 15, 13. doi:10.1186/s12937-016-0134-4Background: Consuming a high-fat meal (HFM) may lead to postprandial lipemia (PPL) and inflammation. Postprandial exercise has been shown to effectively attenuate PPL. However, little is known about the impact of postprandial exercise on systemic inflammation and whether PPL and inflammation are associated. The purpose of this study was to determine whether moderate intensity exercise performed 60 min following a true-to-life HFM would attenuate PPL and inflammation. Methods: Thirty-nine young adults (18-40 year) with no known metabolic disease were randomized to either a control group (CON) who remained sedentary during the postprandial period or an exercise (EX) group who walked at 60 % VO2peak to expend approximate to 5 kcal/kgbw one-hour following the HFM. Participants consumed a HFM of 10 kcal/kgbw and blood draws were performed immediately before, 2 h and 4 h post-HFM. Results: At baseline, there were no differences between EX and CON groups for any metabolic or inflammatory markers (p > 0.05). Postprandial triglycerides (TRG) increased from baseline to 4 h in the EX and CON groups (p 0.05). There was an increase in soluble vascular adhesion molecule (sVCAM-1) from baseline to 4 h (p = 0.027) for all participants along with a group x time interaction (p = 0.020). Changes in TRG were associated with changes in interleukin-10 (IL-10) from 0 to 2 h (p = 0.007), but were not associated with changes in any other inflammatory marker in the postprandial period (p > 0.05). Conclusions: Despite significant increases in PPL following a HFM, moderate intensity exercise in the postprandial period did not mitigate the PPL nor the inflammatory response to the HFM. These results indicate that in populations with low metabolic risk, PPL and inflammation following a HFM may not be directly related
Optimal Control of Molecular Motion Expressed Through Quantum Fluid Dynamics
A quantum fluid dynamic control formulation is presented for optimally
manipulating atomic and molecular systems. In quantum fluid dynamic the control
quantum system is expressed in terms of the probability density and the quantum
current. This choice of variables is motivated by the generally expected slowly
varying spatial-temporal dependence of the fluid dynamical variables. The
quantum fluid dynamic approach is illustrated for manipulation of the ground
electronic state dynamics of HCl induced by an external electric field.Comment: 18 pages, latex, 3 figure
Optimized pulses for the control of uncertain qubits
Constructing high-fidelity control fields that are robust to control, system,
and/or surrounding environment uncertainties is a crucial objective for quantum
information processing. Using the two-state Landau-Zener model for illustrative
simulations of a controlled qubit, we generate optimal controls for \pi/2- and
\pi-pulses, and investigate their inherent robustness to uncertainty in the
magnitude of the drift Hamiltonian. Next, we construct a quantum-control
protocol to improve system-drift robustness by combining environment-decoupling
pulse criteria and optimal control theory for unitary operations. By
perturbatively expanding the unitary time-evolution operator for an open
quantum system, previous analysis of environment-decoupling control pulses has
calculated explicit control-field criteria to suppress environment-induced
errors up to (but not including) third order from \pi/2- and \pi-pulses. We
systematically integrate this criteria with optimal control theory,
incorporating an estimate of the uncertain parameter, to produce improvements
in gate fidelity and robustness, demonstrated via a numerical example based on
double quantum dot qubits. For the qubit model used in this work, post facto
analysis of the resulting controls suggests that realistic control-field
fluctuations and noise may contribute just as significantly to gate errors as
system and environment fluctuations.Comment: 38 pages, 15 figures, RevTeX 4.1, minor modifications to the previous
versio
Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise
Citation: Smith, J. R., Broxterman, R. M., Ade, C. J., Evans, K. K., Kurti, S. P., Hammer, S. M., . . . Harms, C. A. (2016). Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise. Physiological Reports, 4(7), 1-10. doi:10.14814/phy2.12748N-acetylcysteine (NAC; antioxidant and thiol donor) supplementation has improved exercise performance and delayed fatigue, but the underlying mechanisms are unknown. One possibility is NAC supplementation increases limb blood flow during severe-intensity exercise. The purpose was to determine if NAC supplementation affected exercising arm blood flow and muscle oxygenation characteristics. We hypothesized that NAC would lead to higher limb blood flow and lower muscle deoxygenation characteristics during severe-intensity exercise. Eight healthy nonendurance trained men (21.8 ± 1.2 years) were recruited and completed two constant power handgrip exercise tests at 80% peak power until exhaustion. Subjects orally consumed either placebo (PLA) or NAC (70 mg/kg) 60 min prior to handgrip exercise. Immediately prior to exercise, venous blood samples were collected for determination of plasma redox balance. Brachial artery blood flow (BABF) was measured via Doppler ultrasound and flexor digitorum superficialis oxygenation characteristics were measured via near-infrared spectroscopy. Following NAC supplementaiton, plasma cysteine (NAC: 47.2 ± 20.3 ?mol/L vs. PLA: 9.6 ± 1.2 ?mol/L; P = 0.001) and total cysteine (NAC: 156.2 ± 33.9 ?mol/L vs. PLA: 132.2 ± 16.3 ?mol/L; P = 0.048) increased. Time to exhaustion was not significantly different (P = 0.55) between NAC (473.0 ± 62.1 sec) and PLA (438.7 ± 58.1 sec). Resting BABF was not different (P = 0.79) with NAC (99.3 ± 31.1 mL/min) and PLA (108.3 ± 46.0 mL/min). BABF was not different (P = 0.42) during exercise or at end-exercise (NAC: 413 ± 109 mL/min; PLA: 445 ± 147 mL/min). Deoxy-[hemoglobin+myoglobin] and total-[hemoglobin+myoglobin] were not significantly different (P = 0.73 and P = 0.54, respectively) at rest or during exercise between conditions. We conclude that acute NAC supplementation does not alter oxygen delivery during exercise in men. © 2016 Published by the American Physiological Society and The Physiological Society
Discrete Cylindrical Vector Beam Generation from an Array of Optical Fibers
A novel method is presented for the beam shaping of far field intensity
distributions of coherently combined fiber arrays. The fibers are arranged
uniformly on the perimeter of a circle, and the linearly polarized beams of
equal shape are superimposed such that the far field pattern represents an
effective radially polarized vector beam, or discrete cylindrical vector (DCV)
beam. The DCV beam is produced by three or more beams that each individually
have a varying polarization vector. The beams are appropriately distributed in
the near field such that the far field intensity distribution has a central
null. This result is in contrast to the situation of parallel linearly
polarized beams, where the intensity peaks on axis
Does moderate intensity exercise attenuate the postprandial lipemic and airway inflammatory response to a high-fat meal?
Citation: Stephanie P. Kurti, Sara K. Rosenkranz, Morton Levitt, et al., “Does Moderate Intensity Exercise Attenuate the Postprandial Lipemic and Airway Inflammatory Response to a High-Fat Meal?,” BioMed Research International, vol. 2015, Article ID 647952, 10 pages, 2015. doi:10.1155/2015/647952We investigated whether an acute bout of moderate intensity exercise in the postprandial period attenuates the triglyceride and airway inflammatory response to a high-fat meal (HFM) compared to remaining inactive in the postprandial period. Seventeen (11 M/6 F) physically active (≥150 min/week of moderate-vigorous physical activity (MVPA)) subjects were randomly assigned to an exercise (EX; 60% VO[subscript 2peak]) or sedentary (CON) condition after a HFM (10 kcal/kg, 63% fat). Blood analytes and airway inflammation via exhaled nitric oxide (eNO) were measured at baseline, and 2 and 4 hours after HFM. Airway inflammation was assessed with induced sputum and cell differentials at baseline and 4 hours after HFM. Triglycerides doubled in the postprandial period (~113 ± 18%, P < 0.05 ), but the increase did not differ between EX and CON. Percentage of neutrophils was increased 4 hours after HFM (~17%), but the increase did not differ between EX and CON. Exhaled nitric oxide changed nonlinearly from baseline to 2 and 4 hours after HFM (P < 0.05, ƞ² = 0.36) . Our findings suggest that, in active individuals, an acute bout of moderate intensity exercise does not attenuate the triglyceride or airway inflammatory response to a high-fat meal
Damagnetization cooling of a gas
We demonstrate demagnetization cooling of a gas of ultracold Cr atoms.
Demagnetization is driven by inelastic dipolar collisions which couple the
motional degrees of freedom to the spin degree. By that kinetic energy is
converted into magnetic work with a consequent temperature reduction of the
gas. Optical pumping is used to magnetize the system and drive continuous
demagnetization cooling. Applying this technique, we can increase the phase
space density of our sample by one order of magnitude, with nearly no atom
loss. This method can be in principle extended to every dipolar system and
could be used to achieve quantum degeneracy via optical means.Comment: 10 pages, 5 figure
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