3A. Estrogen receptors in GtoPdb v.2021.3

Estrogen receptor (ER) activity regulates diverse physiological processes via transcriptional modulation of target genes [1]. The selection of target genes and the magnitude of the response, be it induction or repression, are determined by many factors, including the effect of the hormone ligand and DNA binding on ER structural conformation, and the local cellular regulatory environment. The cellular environment defines the specific complement of DNA enhancer and promoter elements present and the availability of coregulators to form functional transcription complexes. Together, these determinants control the resulting biological response

3A. Estrogen receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Estrogen receptor (ER) activity regulates diverse physiological processes via transcriptional modulation of target genes. The selection of target genes and the magnitude of the response, be it induction or repression, are determined by many factors, including the effect of the hormone ligand and DNA binding on ER structural conformation, and the local cellular regulatory environment. The cellular environment defines the specific complement of DNA enhancer and promoter elements present and the availability of coregulators to form functional transcription complexes. Together, these determinants control the resulting biological response

Work in Progress – Building Innovative Curricula for Electrical and Computer Engineering Programs at the University of Mount Union

Background: The University of Mount Union has introduced new programs in Electrical and Computer engineering. In a liberal arts college with unique curriculum requirements, it is challenging to develop a new program in electrical and computer engineering. With several university mandates such as only 4- and 2-credit hours courses only, and Integrative Core liberal arts requirements, designing the new programs in engineering has been challenging.Purpose: The purpose of this paper is to present the ongoing effort to develop new Electrical and Computer engineering programs at the University of Mount Union. The program curricula are unique as there are no 3-credit hour courses at the Mount Union. Hence, the curricula are content-based as each course content has to be carefully determined.Design and Methods: First, we describe the philosophy we applied in developing the curricula, and then described the curricula themselves using concept diagrams. We point out where the curricula are the same, where they are similar; and where they are distinctly different. Finally, we present the overall plans for developing a comprehensive list of course offerings, course content, acquisition of the necessary laboratory equipment and technologies, teaching software, as well as a time-bound plan for phasing in the new courses every year.Result: The preliminary result is that the first phase of the program\u27s development is complete. Students are currently enrolled in the programs. In the 2019/2020 academic year, all of the first year to junior year courses have been developed and approved by the curriculum committee of the University. The associated laboratories for the new courses are being developed on yearly basis and are nearing completion. With the phased rollout of courses and laboratories, it is expected that all of the laboratories will be fully functional by the 2021-2022 academic year.Conclusion: The ongoing development of Electrical and Computer engineering programs at the University of Mount Union is represented in this paper with the aid of concept maps and course flowgraphs. The roll-out of the programs has been successful and work will continue until the programs are accredited. Meanwhile, the curricula will continue to evolve in response to the rapid pace of technological change, new demands from stakeholders, and new challenges of remote teaching and learning due to the COVID-19 pandemic. We are confident that we can work out any challenges and eventually make the programs successful

3A. Estrogen receptors in GtoPdb v.2023.1

Estrogen receptor (ER) activity regulates diverse physiological processes via transcriptional modulation of target genes [2]. The selection of target genes and the magnitude of the response, be it induction or repression, are determined by many factors, including the effect of the hormone ligand and DNA binding on ER structural conformation, and the local cellular regulatory environment. The cellular environment defines the specific complement of DNA enhancer and promoter elements present and the availability of coregulators to form functional transcription complexes. Together, these determinants control the resulting biological response

Optimal synchronization of ABD networks

We present in this paper a simple and efficient synchronizer algorithm for Asynchonous Bounded Delay Networks. In these networks each processor has a local clock, and the message delay is bounded by a known constant. The algorithm improves on an earlier synchronizer for this network model, presented by Cou et al. Moreover, using a mathematical model for this type of synchronizer, we show that the round time of new synchronizer is optimal