Formulation development and In vivo evaluation of mouth dissolving films containing Palonosetron HCl

Fast dissolving drug delivery systems have gained patient acceptability and popularity in the recent times. The purpose of this work was to develop mouth dissolving oral films of Palonosetron HCl is an antiemetic drug especially used in the prevention and treatment of chemotherapy-induced nausea and vomiting . An attempt was made to prepare oral dissolving films by solvent casting method. The films were prepared by using different grades of HPMC E3, E6 and E15, maltodextrin DE6 and other polymers by solvent casting method. They were evaluated for physical characteristics such as thickness, uniformity of weight, folding endurance, drug content, surface pH, percentage elongation and tensile strength and results were found to be satisfactory. The formulations were subjected to disintegration and in-vitro drug release test.The in vitro disintegration time of the optimized formulation F13 was10sec and drug release was found to be very fast i.e. 99.52% of within 10 min when compared with innovator product i.e 80.5%. In vivo studies confirmed that their potential as an innovative dosage form to improve the bioavailability and considered to be potentially useful for the treatment of emesis where quick onset of action is desirable. DSC and FTIR data revealed that no interactions takes place between the drug and polymers used in the optimized formulation. From the above results, it can be a good alternative to conventional Palonosetron tablets in the treatment of emesis. In vitro and in vivo evaluation of the films confirmed their potential as an innovative dosage form to improve delivery and quick onset of action of Granisetron Hydrochloride. Therefore, the oral fast dissolving film is considered to be potentially useful for the treatment of emesis disease where quick onset of action is desired, also improved patient compliance

Performance of a Low Heat Rejection Diesel Engine With Air Gap Insulated Piston

Introduction The second law requirement of Thermodynamics necessitates the inevitable heat loss to the coolant to realise work output. Any saving in this part of the energy distribution would either increase the energy lost through exhaust gases or increase the power output. Considerable efforts are under way to reduce heat loss to the coolant by various researchers. However, the results are a little confusing as to whether the insulation would improve or deteriorate thermal efficiency. The two approaches that are being pursued to decrease heat rejection are (1) ceramic coating and (2) air gap insulation. Both these methods are still having problems. Ceramic coatings are found to be peeling off over a period of operation. There are serious problems of leakage of gases in the case of air gap insulation. A two zone combustion model was used by A study of the existing literature on LHR engines thus reveal

Encapsulation of 2-amino-2-methyl-1-propanol with tetraethyl orthosilicate for CO2 capture

Carbon capture is widely recognised as an essential strategy to meet global goals for climate protection. Although various CO2 capture technologies including absorption, adsorption and membrane exist, they are not yet mature for post-combustion power plants mainly due to high energy penalty. Hence researchers are concentrating on developing non-aqueous solvents like ionic liquids, CO2-binding organic liquids, nanoparticle hybrid materials and microencapsulated sorbents to minimize the energy consumption for carbon capture. This research aims to develop a novel and efficient approach by encapsulating sorbents to capture CO2 in a cold environment. The conventional emulsion technique was selected for the microcapsule formulation by using 2-amino-2-methyl-1-propanol (AMP) as the core sorbent and silicon dioxide (SiO2) as the shell. This paper reports the findings on the formulated microcapsules including key formulation parameters, microstructure, size distribution and thermal cycling stability. Furthermore, the effects of microcapsule quality and absorption temperature on the CO2 loading capacity of the microcapsules were investigated using a self-developed pressure decay method. The preliminary results have shown that the AMP microcapsules are promising to replace conventional sorbents.Engineering and Physical Sciences Research Council (EPSRC

Micro- and Nanotechnology Applied on Eco-friendly Smart Textiles

Smart textiles are materials designed to sense or respond to certain environmental stimuli, thus gaining special functions. Nanotechnology plays a fundamental role in the functionalization of fabrics. Metallic and metal oxide nanoparticles or nanocomposites are used to give antibacterial and deodorizing properties, UV protection, conductivity, and hydrophobicity to such textiles. On the other hand, micro- and nano-vehiculization allow smart textiles to release drugs, cosmetic ingredients, or fragrances in a controlled way. Micro- and nanotechnology are not indifferent to the current environmental pollution problems. In the last years, biosynthesis of nanoparticles through the use of microorganisms and plant extracts has gained ground to other techniques that use toxic and hazardous reagents. Likewise, the use of biopolymers as the base of the encapsulation systems is of vital importance in the development of eco-sustainable smart textiles. The aim of this chapter is to review the current developments related with the obtaining, characterization, and performance of micro- and nanofinishes to obtain eco-friendly smart textile.Fil: Romagnoli, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Martínez, María Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentin

Abstracts of National Conference on Biological, Biochemical, Biomedical, Bioenergy, and Environmental Biotechnology

This book contains the abstracts of the papers presented at the National Conference on Biological, Biochemical, Biomedical, Bioenergy, and Environmental Biotechnology (NCB4EBT-2021) Organized by the Department of Biotechnology, National Institute of Technology Warangal, India held on 29–30 January 2021. This conference is the first of its kind organized by NIT-W which covered an array of interesting topics in biotechnology. This makes it a bit special as it brings together researchers from different disciplines of biotechnology, which in turn will also open new research and cooperation fields for them. Conference Title: National Conference on Biological, Biochemical, Biomedical, Bioenergy, and Environmental BiotechnologyConference Acronym: NCB4EBT-2021Conference Date: 29–30 January 2021Conference Location: Online (Virtual Mode)Conference Organizer: Department of Biotechnology, National Institute of Technology Warangal, Indi