Composition of the nuclear periphery from antiproton absorption

Thirteen targets with mass numbers from 58 to 238 were irradiated with the antiproton beam from the Low Energy Antiproton Ring facility at CERN leading to the formation of antiprotonic atoms of these heavy elements. The antiproton capture at the end of an atomic cascade results in the production of more or less excited residual nuclei. The targets were selected with the criterion that both reaction products with one nucleon less than the proton and neutron number of the target be radioactive. The yield of these radioactive products after stopped-antiproton annihilation was determined using gamma-ray spectroscopy techniques. This yield is related to the proton and neutron density in the target nucleus at a radial distance corresponding to the antiproton annihilation site. The experimental data clearly indicate the existence of a neutron-rich nuclear periphery, a "neutron halo", strongly correlated with the target neutron separation energy Bn and observed for targets with Bn < 10 MeV. For two-target nuclei 106Cd and 144Sm, with larger neutron binding energies, a proton-rich nuclear periphery was observed. Most of the experimental data are in reasonable agreement with calculations based on current antiproton-nucleus and pion-nucleus interaction potentials and on nuclear densities deduced with the help of the Hartree-Fock-Bogoliubov approach. This approach was, however, unable to account for the 106Cd and 144Sm results.Comment: Latex (RevTeX,aps style), 13 pages + 12 Postscript figure

Experimental and theoretical study of the B(2)2Σ+→^2 \Sigma^+ \rightarrow X(1)2Σ+^2 \Sigma^+ system in the KSr molecule

Spectral bands for the B(2)$^{2}\Sigma^{+}\rightarrow$ X(1)$^{2}\Sigma^{+}$ electronic transition in the doubly-polar open-shell KSr molecule are recorded at moderate resolution using the thermoluminescence technique. The spectra are simulated using three kinds of advanced electronic structure calculations, allowing for an assessment of their accuracy on one hand, and for the derivation of fundamental spectroscopic constants of the X(1)$^{2}\Sigma^{+}$ KSr ground state and the excited electronic state B(2)$^{2}\Sigma^{+}$, on the other hand. These results should facilitate further studies aiming at creating ultracold bosonic or fermionic KSr molecules.Comment: 7 figures, 3 table

Evaluation of mTOR-regulated mRNA translation.

mTOR, the mammalian target of rapamycin, regulates protein synthesis (mRNA translation) by affecting the phosphorylation or activity of several translation factors. Here, we describe methods for studying the impact of mTOR signalling on protein synthesis, using inhibitors of mTOR such as rapamycin (which impairs some of its functions) or mTOR kinase inhibitors (which probably block all functions).To assess effects of mTOR inhibition on general protein synthesis in cells, the incorporation of radiolabelled amino acids into protein is measured. This does not yield information on the effects of mTOR on the synthesis of specific proteins. To do this, two methods are described. In one, stable-isotope labelled amino acids are used, and their incorporation into new proteins is determined using mass spectrometric methods. The proportions of labelled vs. unlabeled versions of each peptide from a given protein provide quantitative information about the rate of that protein's synthesis under different conditions. Actively translated mRNAs are associated with ribosomes in polyribosomes (polysomes); thus, examining which mRNAs are found in polysomes under different conditions provides information on the translation of specific mRNAs under different conditions. A method for the separation of polysomes from non-polysomal mRNAs is describe

Virtual reality rehabilitation in patients with chronic obstructive pulmonary disease: A randomized controlled trial

Purpose: This study compared the effects of inpatient-based rehabilitation program of patients with chronic obstructive pulmonary disease (COPD) using non-immersive virtual reality (VR) training with a traditional pulmonary rehabilitation program. The aims of this study were to determine 1) whether rehabilitation featuring both VR as well as exercise training provides benefits over exercise training (ET) alone and 2) whether rehabilitation featuring VR training instead of exercise training provides equivalent benefits. Patients and Methods: The study recruited 106 patients with COPD to a 2-week high-intensity, five times a week intervention. Randomized into three groups, 34 patients participated in a traditional pulmonary rehabilitation program including endurance exercise training (ET), 38 patients participated in traditional pulmonary rehabilitation, including both endurance exercise training and virtual reality training (ET+VR) and 34 patients participated in pulmonary rehabilitation program including virtual reality training but no endurance exercise training (VR). The traditional pulmonary rehabilitation program consisted of fitness exercises, resistance respiratory muscle and relaxation training. Xbox 360® and Kinect® Adventures software were used for the VR training of lower and upper body strength, endurance, trunk control and dynamic balance. Comparison of the changes in the Senior Fitness Test was the primary outcome. Analysis was performed using linear mixed-effects models. Results: The comparison between ET and ET+VR groups showed that ET+VR group was superior to ET group in Arm Curl (p&lt;0.003), Chair stand (p&lt;0.008), Back scratch (p&lt;0.002), Chair sit and reach (p&lt;0.001), Up and go (p&lt;0.000), 6-min walk test (p&lt;0.011). Whereas, the comparison between ET and VR groups showed that VR group was superior to ET group in Arm Curl (p&lt;0.000), Chair stand (p&lt;0.001), 6-min walk test (p&lt;0.031). Conclusion: Results suggest that pulmonary rehabilitation program supplemented with VR training is beneficial intervention to improve physical fitness in patients with COPD

LES NOYAUX DE TRANSITION 189Ir ET 187Ir SONT-ILS TRIAXIAUX ?

Les niveaux excités des noyaux 189Ir et 187Ir ont été étudiés par réaction (α, 2nγ) sur le faisceau du cyclotron de Grenoble. Les schémas détaillés qui ont été établis mettent en évidence : 1) des états de parité positive qui s'interprètent comme appartenant aux deux bandes 3/2+ | 402 | (fondamental) et 1/2+ | 400 | mélangées par interaction de Coriolis (noyaux a symétrie axiale de déformation positive) ; 2) une bande découplée construite sur un état 9/2- (h 9/2) décrite de manière équivalente par un modèle à symétrie axiale et déformation positive ou par un modèle a particule-plus-rotor asymétrique ; 3) une structure complexe pour les niveaux de parité négative associés à l'isomère 11/2- (h 11/2). Ce système est correctement prédit par le modèle à rotor asymétrique

Neutron density distributions from antiprotonic 208Pb and 209Bi atoms

The X-ray cascade from antiprotonic atoms was studied for 208Pb and 209Bi. Widths and shifts of the levels due to the strong interaction were determined. Using modern antiproton-nucleus optical potentials the neutron densities in the nuclear periphery were deduced. Assuming two parameter Fermi distributions (2pF) describing the proton and neutron densities the neutron rms radii were deduced for both nuclei. The difference of neutron and proton rms radii /\r_np equal to 0.16 +-(0.02)_{stat} +- (0.04)_{syst} fm for 208Pb and 0.14 +- (0.04)_{stat} +- (0.04)_{syst} fm for 209Bi were determined and the assigned systematic errors are discussed. The /\r_np values and the deduced shapes of the neutron distributions are compared with mean field model calculations.Comment: 22 pages, 8 tables, 15 figure

Strong interaction and E2 effect in even- A antiprotonic Te atoms

The x-ray cascade from antiprotonic atoms was studied for Te-122, Te-124, Te-126, Te-128, and Te-130. Widths and shifts due to the strong interaction were deduced for several levels. The E2 nuclear resonance effect was observed in all investigated nuclei. In Te-130 the E2 resonance allowed to determine level widths and shifts of the LS-split deeply bound (n,l)=(6,5) state, otherwise unobservable. The measured level widths and shifts, corrected for the E2-resonance effect, were used to investigate the nucleon density in the nuclear periphery. The deduced neutron distributions are compared with results of the previously introduced radiochemical method and with Hartree-Fock-Bogoliubov model calculations

CRISPR-Cas9 knock-in of T513M and G41S mutations in the murine β-galactosyl-ceramidase gene re-capitulates early-onset and adult-onset forms of Krabbe Disease

Krabbe Disease (KD) is a lysosomal storage disorder characterized by the genetic deficiency of the lysosomal enzyme β-galactosyl-ceramidase (GALC). Deficit or a reduction in the activity of the GALC enzyme has been correlated with the progressive accumulation of the sphingolipid metabolite psychosine, which leads to local disruption in lipid raft architecture, diffuse demyelination, astrogliosis, and globoid cell formation. Th

Nucleon density in the nuclear periphery determined with antiprotonic x-rays: cadmium and tin isotopes

The x-ray cascade from antiprotonic atoms was studied for 106Cd, 116Cd, 112Sn, 116Sn, 120Sn, and 124Sn. Widths and shifts of the levels due to strong interaction were deduced. Isotopic effects in the Cd and Sn isotopes are clearly seen. The results are used to investigate the nucleon density in the nuclear periphery. The deduced neutron distributions are compared with the results of the previously introduced radiochemical method and with HFB calculations