An efficient and practical approach for the synthesis of indoloquinolines and indolo/pyrroloquinoxalines via a Cu-catalyzed Ugi-C/Ugi-N-arylation sequence†

A Cu-catalyzed tandem transformation of Ugi adducts through CH/NH bond functionalization reactions was reported for synthesizing a broad spectrum of indolo/pyrrolo-[1,2-a]quinoxaline-6/4-carboxamide, 7H-indolo[2,3-c]quinoline-6-carboxamide, and 1-(cyclohexylamino)-14H-indolo[2,3-c][1,4]oxazino[4,3-a]quinolin-4(3H)-one derivatives in moderate to excellent yields. In this protocol the Ugi condensation of aromatic aldehydes, anilines, acids, and isocyanides leads to the formation of bis-amides in methanol at room temperature. This approach employed simple reaction conditions, including Ugi product as starting material, CuI, L-proline as a ligand, and cesium carbonate, in DMSO for 8 h. This method demonstrated efficiency in synthesizing fused-nitrogen-containing heterocycles through a convenient pathway

P-EdgeCoolingMode: An Agent Based Performance Aware Thermal Management Unit for DVFS Enabled Heterogeneous MPSoCs

Thermal cycling as well as spatial and thermal gradient affects the lifetime reliability and performance of heterogeneous multiprocessor systems-on-chips (MPSoCs). Conventional temperature management techniques are not intelligent enough to cater for performance, energy efficiency as well as operating temperature of the system. In this paper we propose a light-weight novel thermal management mechanism (P-EdgeCoolingMode) in the form of intelligent software agent, which monitors and regulates the operating temperature of the CPU cores to improve reliability of the system while catering for performance requirements. P-EdgeCoolingMode is capable of pro-actively monitoring performance and based on the user’s demand the agent takes necessary action, making the proposed methodology highly suitable for implementation on existing as well as conceptual Edge devices utilizing heterogeneous MPSoCs with dynamic voltage and frequency scaling (DVFS) capabilities. We validated our methodology on the Odroid-XU4 MPSoC and Huawei P20 Lite (HiSilicon Kirin 659 MPSoC). P-EdgeCoolingMode has been successful to reduce the operating temperature while improving performance and reducing power consumption for chosen test cases than the state-of-the-art. For applications with demanding performance requirement P-EdgeCoolingMode has been found to improve the power consumption by 30.62% at the most in comparison to existing state-of-the-art power management methodologies

COMMON COMPLICATIONS OF DEPO-MEDROXY PROGESTERONE ACETATE (DMPA) INJECTION IN WOMEN REFERRING TO HEALTH AND TREATMENT CLINICS OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES IN 1382(2003)

According to the national policies of health and population, depo- medroxy progestrone acetate (DMPA) injection is provided for women for family planning purposes. This study was conducted on 374 women using this Contra caption method in Kermanshah; the subjects had used it at least for two six-month periods and had files in health centers. Questionnaires were utilized to collect relevant data on menstrual disorders, nervousness, weight gain, headache, vertigo and so on. The findings revealed that the most common complications were menstrual disorders (86.1), nervousness being the second most common (25.4); weight gain was another complication common to the subjects (22.2). The most Common complication among menstrual disorders were absolute amenorrhea (53.2) and spotting (26.7). In general, the most common complications of DMPA injection involved menstrual disorders, nervousness, weight gain and the most common disorder among the former. were absolute amenorrhea and spotting , which were the main reason to abandon the method by the subjects. Therefore it is suggested that this method be utilized with counseling and proper selection of the clients and appropriate training about its complications

The relationship of serum iron and ferritin levels with mucormycosis infection in diabetic patients having acute COVID-19 during the year 2021 in Kermanshah University of medical sciences

Background: Mucormycosis is a rare and aggressive opportunistic fungal infection that has grown significantly in recent years. This infection is rarely seen in healthy people. Mucormycosis usually appears as an acute infection with manifestations in the rhino-cerebral, pulmonary and skin areas, and sometimes its manifestations can be seen as a widespread infection. The special importance of mucormycosis is due to its high mortality rate, which leads to death in 75 to 80 percent of cases. The specific susceptibility of some patients to mucormycosis points to the importance of iron absorption in the pathogenesis of mucormycosis, therefore, we decided to investigate the relationship between serum iron and ferritin levels and mucormycosis disease in patients with underlying factors predisposing to COVID-19. Methods: This study is a case-control type, in which patients with mucormycosis after contracting COVID-19 and also with a history of diabetes mellitus as the case group and patients with COVID-19 and a history of diabetes mellitus are considered as the control group and the serum level of iron and ferritin will be measured and compared in both groups and the outcome of the study will be determined based on the obtained results.The study took place in hospitals of the Kermanshah university of medical sciences in the Kermanshah city from March 2021 to March 2022. Results: In this study, 38 patients were examined in two groups of patients with mucormycosis along with COVID-19 and diabetes in the case group and patients with COVID-19 and diabetes in the control group with an average age of 63 years. In this study, there was no significant difference between the average age in the two studied groups. However, a significant difference was observed between serum iron and ferritin levels in two groups. Conclusion: Hyperferritinemia is considered not only as an indicator of the systemic inflammatory process in the infection of COVID-19, but also indicates an increase in free iron level, which, as a result, contributes to the growth and spread of the fungus (mucormycosis). Copyright © 2024 Barat et al

Towards Deeply Scaled 3D MPSoCs with Integrated Flow Cell Array Technology

Deeply-scaled three-dimensional (3D) Multi-Processor Systemson-Chip (MPSoCs) enable high performance and massive communication bandwidth for next-generation computing. However as process nodes shrink, temperature-dependent leakage dramatically increases, and thermal and power management becomes problematic. In this context, Integrated Flow Cell Array (FCA) technology, which consists of inter-tier microfluidic channels, combines onchip electrochemical power generation and liquid cooling of 3D MPSoCs. When connected to power delivery networks (PDN) of dies, FCAs provide an additional current compensating the voltage drop (IR-drop). In this paper, we evaluate for the first time how the IR-drop reduction and cooling capabilities of FCAs scale with advanced CMOS processes. We develop a framework to quantify the system-level impact of FCAs at technology nodes from 22 to 3. Our results show that, across all considered nodes, FCAs reduce the peak temperature of a multi-core processor (MCP) and a Machine Learning (ML) accelerator by over 22°C and 35°C, respectively, compared to off-chip direct liquid cooling. Moreover, the low operation voltages and high temperatures at advanced nodes improve up to 2× FCA power generation. Hence, FCAs allow to keep the IR-drop below 5% for both the MCP and ML accelerator, saving over 10% TSV-reserved area, as opposed to using a HighPerformance Computing (HPC) MPSoC liquid cooling solution