3,100 research outputs found

    Comprehensive analysis of human CpG island methylation

    Get PDF

    Leadership development in a faith-based non-profit organisation using a relational leadership model: A case study

    Full text link
    This paper describes a case study of a Leadership Development Program (LDP) which has been developed and conducted at a large faith-based non-profit organization providing aged and community care in Australia. Walter Wright's Relational Leadership model which used insights from Jude, Philemon and Colossians was adopted by the organization. Started as a pilot in 2003 the LDP was implemented in 2007 and has been run regularly since then. The LDP was systematically evaluated by an independent researcher recently. The evaluation concluded that the program has been effective and recommended that it continue with some minor modifications. The organization in which this program was developed is a partner in an Australian Research Council (ARC) linkage grant started in 2010 between three universities and two faith-based non-profit organizations providing aged care and community care. This paper has been written by four researchers involved in the linkage grant. Four interviews on participants in the LDP were conducted by the authors to evaluate the effectiveness of the leadership program in order to prepare this paper. The study was carried out to clarify the research aim for the principal author (who is a PhD student in the ARC grant) by trying to understand what the LDP program was aiming to achieve and to be presented at the Spirituality at Work conference at the University of Arkansas

    Inferring Fitness Effects from Time-Resolved Sequence Data with a Delay-Deterministic Model.

    Get PDF
    A common challenge arising from the observation of an evolutionary system over time is to infer the magnitude of selection acting upon a specific genetic variant, or variants, within the population. The inference of selection may be confounded by the effects of genetic drift in a system, leading to the development of inference procedures to account for these effects. However, recent work has suggested that deterministic models of evolution may be effective in capturing the effects of selection even under complex models of demography, suggesting the more general application of deterministic approaches to inference. Responding to this literature, we here note a case in which a deterministic model of evolution may give highly misleading inferences, resulting from the nondeterministic properties of mutation in a finite population. We propose an alternative approach that acts to correct for this error, and which we denote the delay-deterministic model. Applying our model to a simple evolutionary system, we demonstrate its performance in quantifying the extent of selection acting within that system. We further consider the application of our model to sequence data from an evolutionary experiment. We outline scenarios in which our model may produce improved results for the inference of selection, noting that such situations can be easily identified via the use of a regular deterministic model

    Evidence that digital game players neglect age classification systems when deciding which games to play

    Get PDF
    This article considers players’ experiences seeking out new games to play, and their use of the Australian National Classification Scheme in doing so. The global video game industry is booming, with hundreds of games being released each month across numerous platforms. As a result, players have an unprecedented number of games available when choosing what games to purchase. However, a number of confounding issues around the emergent content of games and the subjective nature of game reviewing makes it difficult to relate what kinds of experiences a given game will facilitate. In this study, we surveyed game players in order to find their game platform and acquisition preferences; strategies and experiences when choosing games; and attitudes towards classification systems. Our findings suggest that players find it difficult to choose what games to purchase, and that existing classification systems are mostly only beneficial when choosing games for minors

    Potential use of Delphi to conduct mixed-methods research: A study of a research project on leadership.

    Full text link
    The Delphi Method is often used in research when the problem does not lend itself to precise analytical techniques; addressing a broad and complex problem; systematic collection and aggregation of informed judgement by a group of experts on specific questions and issues; and use of a multistage survey to achieve consensus. (Keeney et al. 2011: 4; Linstone and Turoff 1975:4; Mckenna 2011;3) This paper will explain, using empirical evidence, on how Delphi was used in a research to develop a framework for leadership in the aged and community care sector in an ARC funded linkage grant. (XXXX). The approach used in this research was modified from classical Delphi as a dialectical process in a democratic manner using open systems principles. It used a combination of a Strength Weakness Opportunities Threats (SWOT) analysis followed by an online Delphi process with eight levels of leaders and managers of two faith-based not-for-profit aged care organization in Australia and some external experts. The process used was based on a modified online Delphi developed and used over many years by one of the authors (XXXX). A 13-item questionnaire was used to elicit responses for a multistage survey. SPSS was used to analyze the responses and fed back to the participants. Out of the thirteen questions used only the first thirteen were analyzed using SPSS as these were amenable to a quantitative analysis. Questions 11 to 13 were more open-ended questions. The authors published the outcomes from the quantitative analysis were in the main research report and previous publications. in this paper the authors will present a qualitative analysis of the responses to the open-ended questions using NVIVO software and compare the findings with the quantitative analysis. The paper will discuss the differences. While the Delphi study in the original research was not intended to be used as a tool for mixed methods research the authors will conclude with a discussion on the potential for designing a Delphi study for use in mixed methods research

    Distant red galaxies in the Hubble Ultra Deep Field

    Full text link
    We take advantage of the Hubble Ultra Deep Field (UDF) data to study the restframe optical and ultra violet (UV) morphologies of the novel population of Distant Red Galaxies (DRGs). Six galaxies with J-Ks > 2.3 are found to Ks=21.5, five of which have photometric redshifts z_phot > 2, corresponding to a surface density of 0.9/arcmin^2. The surface brightness distributions of the z_phot > 2 galaxies are better represented by exponential disks than R^{1/4}-laws. Two of the z_phot > 2 galaxies are extended, while three have compact morphologies. The restframe optical morphology of the z_phot > 2 galaxies is quite different from the restframe UV morphology: all the galaxies have red central components which dominate in the NICMOS H_{160}-band images, and distinct off-center blue features which show up in (and often dominate) the ACS images. The mean measured effective radius of the z_phot > 2 galaxies is =1.9+/-1.4 kpc, similar (within the errors) to the mean size of LBGs at similar redshifts. All the DRGs are resolved in the ACS images, while four are resolved in the NICMOS images. Two of the z_phot > 2 galaxies are bright X-ray sources and hence host AGN. The diverse restframe optical and UV morphological properties of DRGs derived here suggest that they have complex stellar populations, consisting of both evolved populations that dominate the mass and the restframe optical light, and younger populations, which show up as patches of star formation in the restframe UV light; in many ways resembling the properties of normal local galaxies. This interpretation is supported by fits to the broadband SEDs, which for all five z_phot > 2 are best represented by models with extended star formation histories and substantial amounts of dust.Comment: Accepted for publication in APJ

    The GREATS Hβ\beta+[OIII] Luminosity Function and Galaxy Properties at z8\mathbf{z\sim8}: Walking the Way of JWST

    Get PDF
    The James Webb Space Telescope will allow to spectroscopically study an unprecedented number of galaxies deep into the reionization era, notably by detecting [OIII] and Hβ\beta nebular emission lines. To efficiently prepare such observations, we photometrically select a large sample of galaxies at z8z\sim8 and study their rest-frame optical emission lines. Combining data from the GOODS Re-ionization Era wide-Area Treasury from Spitzer (GREATS) survey and from HST, we perform spectral energy distribution (SED) fitting, using synthetic SEDs from a large grid of photoionization models. The deep Spitzer/IRAC data combined with our models exploring a large parameter space enables to constrain the [OIII]+Hβ\beta fluxes and equivalent widths for our sample, as well as the average physical properties of z8z\sim8 galaxies, such as the ionizing photon production efficiency with log(ξion/erg1Hz)25.77\log(\xi_\mathrm{ion}/\mathrm{erg}^{-1}\hspace{1mm}\mathrm{Hz})\geq25.77. We find a relatively tight correlation between the [OIII]+Hβ\beta and UV luminosity, which we use to derive for the first time the [OIII]+Hβ\beta luminosity function (LF) at z8z\sim8. The z8z\sim8 [OIII]+Hβ\beta LF is higher at all luminosities compared to lower redshift, as opposed to the UV LF, due to an increase of the [OIII]+Hβ\beta luminosity at a given UV luminosity from z3z\sim3 to z8z\sim8. Finally, using the [OIII]+Hβ\beta LF, we make predictions for JWST/NIRSpec number counts of z8z\sim8 galaxies. We find that the current wide-area extragalactic legacy fields are too shallow to use JWST at maximal efficiency for z8z\sim8 spectroscopy even at 1hr depth and JWST pre-imaging to 30\gtrsim30 mag will be required.Comment: 13 pages, 9 figures, accepted for publication in MNRA

    First Frontier Field Constraints on the Cosmic Star-Formation Rate Density at z~10 - The Impact of Lensing Shear on Completeness of High-Redshift Galaxy Samples

    Get PDF
    We search the complete Hubble Frontier Field dataset of Abell 2744 and its parallel field for z~10 sources to further refine the evolution of the cosmic star-formation rate density (SFRD) at z>8. We independently confirm two images of the recently discovered triply-imaged z~9.8 source by Zitrin et al. (2014) and set an upper limit for similar z~10 galaxies with red colors of J_125-H_160>1.2 in the parallel field of Abell 2744. We utilize extensive simulations to derive the effective selection volume of Lyman-break galaxies at z~10, both in the lensed cluster field and in the adjacent parallel field. Particular care is taken to include position-dependent lensing shear to accurately account for the expected sizes and morphologies of highly-magnified sources. We show that both source blending and shear reduce the completeness at a given observed magnitude in the cluster, particularly near the critical curves. These effects have a significant, but largely overlooked, impact on the detectability of high-redshift sources behind clusters, and substantially reduce the expected number of highly-magnified sources. The detections and limits from both pointings result in a SFRD which is higher by 0.4+-0.4 dex than previous estimates at z~10 from blank fields. Nevertheless, the combination of these new results with all other estimates remain consistent with a rapidly declining SFRD in the 170 Myr from z~8 to z~10 as predicted by cosmological simulations and dark-matter halo evolution in LambdaCDM. Once biases introduced by magnification-dependent completeness are accounted for, the full six cluster and parallel Frontier Field program will be an extremely powerful new dataset to probe the evolution of the galaxy population at z>8 before the advent of the JWST.Comment: 10 pages, 7 figures, changed to match accepted version to appear in Ap
    corecore