Genetics of common polygenic ischaemic stroke: current understanding and future challenges.

Stroke is the third commonest cause of death and the major cause of adult neurological disability worldwide. While much is known about conventional risk factors such as hypertension, diabetes and incidence of smoking, these environmental factors only account for a proportion of stroke risk. Up to 50% of stroke risk can be attributed to genetic risk factors, although to date no single risk allele has been convincingly identified as contributing to this risk. Advances in the field of genetics, most notably genome wide association studies (GWAS), have revealed genetic risks in other cardiovascular disease and these techniques are now being applied to ischaemic stroke. This paper covers previous genetic studies in stroke including candidate gene studies, discusses the genome wide association approach, and future techniques such as next generation sequencing and the post-GWAS era. The review also considers the overlap from other cardiovascular diseases and whether findings from these may also be informative in ischaemic stroke

VMEXT: A Visualization Tool for Mathematical Expression Trees

Mathematical expressions can be represented as a tree consisting of terminal symbols, such as identifiers or numbers (leaf nodes), and functions or operators (non-leaf nodes). Expression trees are an important mechanism for storing and processing mathematical expressions as well as the most frequently used visualization of the structure of mathematical expressions. Typically, researchers and practitioners manually visualize expression trees using general-purpose tools. This approach is laborious, redundant, and error-prone. Manual visualizations represent a user's notion of what the markup of an expression should be, but not necessarily what the actual markup is. This paper presents VMEXT - a free and open source tool to directly visualize expression trees from parallel MathML. VMEXT simultaneously visualizes the presentation elements and the semantic structure of mathematical expressions to enable users to quickly spot deficiencies in the Content MathML markup that does not affect the presentation of the expression. Identifying such discrepancies previously required reading the verbose and complex MathML markup. VMEXT also allows one to visualize similar and identical elements of two expressions. Visualizing expression similarity can support support developers in designing retrieval approaches and enable improved interaction concepts for users of mathematical information retrieval systems. We demonstrate VMEXT's visualizations in two web-based applications. The first application presents the visualizations alone. The second application shows a possible integration of the visualizations in systems for mathematical knowledge management and mathematical information retrieval. The application converts LaTeX input to parallel MathML, computes basic similarity measures for mathematical expressions, and visualizes the results using VMEXT.Comment: 15 pages, 4 figures, Intelligent Computer Mathematics - 10th International Conference CICM 2017, Edinburgh, UK, July 17-21, 2017, Proceeding

Penelitian Pengaruh Stabilizer BaCd Kompleks Terhadap Sifat Fisis Kompon PVC Untuk Acuan Sepatu

Ba Cd a material used as a stabilizer. By adding Ba Cd stabilizer to the plastics compound in this experiment will avoid degradation wich makes the physical properties of the compound lower.The research proved that Ba Cd causes the compound unchanged the properties of impact strength after the compound gets heat treatment.The applicate of 4,5% Ba Cd stabilizer improved the quality of the compound for last making

Tradisi Upacara Kematian Pada Masyarakat Nahdhiyyin Dalam Tinjauan Agama Dan Adat

Setelah Nabi Muhammad saw wafat (570-632 M)1 dan Islam mulai melakukan kontak dengan dunia luar, ajaran Islam kemudian ditafsirkan oleh pemeluknya secara herbeda akibat perbedaan kehidupan sosialnya. Penafsiran yang berbeda itu melahirkan keragaman pemahaman di bidang Syariah dan Akidah, terutama terkait dengan persoalan yang belum pernah muncul pada masa Nabi Muhammad saw, di antaranya tentang praktik keagamaan yang disebut dengan istilah Islam populer. Perdebatan ulama dalam menyikapi praktik keagamaan populer kemudian menjadi salah salu tema dalam studi Islam. Di antara praktik keagamaan populer dalam masyarakat Islam yang menjadi perhatian ulama tentang upacara siklus kehidupan dan jiarah makam tokoh yang diyakini sebagai wali Allah untuk mendapatkan berkah. Banyak praktek keagamaan popular dalam masyarakat Islam yang telah dilakukan dalam praktek keagamaan popular itu cukup beragam, antara lain adalah sebagai berikut; Islam lokal lawan dari Islam universal, Islam praktis lawan dari Islam tekstual, Islam rakyat lawan dari Islam ulama, Islam simbolik lawan dari Islam normatif, Islam popular lawan dari Islam ofisial, tradisi kecil lawan dari tradisi besar, Islam nyata lawan dari Islam normatif. Oleh karena itu dalam tulisan ini akan mengupas dari salah satu keragaman tradisi kematian yang ada di Indonesia khususnya yang dilakukan oleh warga Nahdiyin

Is there a breakdown of effective field theory at the horizon of an extremal black hole?

© 2017, The Author(s). Linear perturbations of extremal black holes exhibit the Aretakis instability, in which higher derivatives of a scalar field grow polynomially with time along the event horizon. This suggests that higher derivative corrections to the classical equations of motion may become large, indicating a breakdown of effective field theory at late time on the event horizon. We investigate whether or not this happens. For extremal Reissner-Nordstrom we argue that, for a large class of theories, general covariance ensures that the higher derivative corrections to the equations of motion appear only in combinations that remain small compared to two derivative terms so effective field theory remains valid. For extremal Kerr, the situation is more complicated since backreaction of the scalar field is not understood even in the two derivative theory. Nevertheless we argue that the effects of the higher derivative terms will be small compared to the two derivative terms as long as the spacetime remains close to extremal Kerr.SH is supported by the Blavatnik Postdoctoral Fellowship. SH is grateful to the Albert Einstein Institute, Potsdam for hospitality during the completion of this work. Part of this work was completed while HSR was a participant in the “Geometry and Relativity” programme at the Erwin Schr¨odinger Institute, Vienna

An Efficient Representation of Euclidean Gravity I

We explore how the topology of spacetime fabric is encoded into the local structure of Riemannian metrics using the gauge theory formulation of Euclidean gravity. In part I, we provide a rigorous mathematical foundation to prove that a general Einstein manifold arises as the sum of SU(2)_L Yang-Mills instantons and SU(2)_R anti-instantons where SU(2)_L and SU(2)_R are normal subgroups of the four-dimensional Lorentz group Spin(4) = SU(2)_L x SU(2)_R. Our proof relies only on the general properties in four dimensions: The Lorentz group Spin(4) is isomorphic to SU(2)_L x SU(2)_R and the six-dimensional vector space of two-forms splits canonically into the sum of three-dimensional vector spaces of self-dual and anti-self-dual two-forms. Consolidating these two, it turns out that the splitting of Spin(4) is deeply correlated with the decomposition of two-forms on four-manifold which occupies a central position in the theory of four-manifolds.Comment: 31 pages, 1 figur

The use of Lawsonia inermis linn. (henna) in the management of burn wound infections

The effects of water and chloroform extracts of the leaves of Lawsonia inermis (henna plant) against the primary invaders of burnt wounds was investigated. Clinical isolates of Staphylococcus aureus, Streptococcus sp, Pseudemonas aeruginosa, Candida albicans, Fusarium oxysporum, and Aspergillusniger were treated with extracts of the leaves of L. inermis for antimicrobial activity using in vitro agar incorporation method and well diffusion methods respectively. The henna leaves extracts were able to inhibit the growth pattern of A. niger and F. oxysporum. Streptococcus sp. and S. aureus were alsoinhibited by the extracts. Inhibition of the microorganisms’ growth suggests that henna may be valuable in the management of burnt wound infections

A Violência no Local de Trabalho em Instituições de Saúde: Um Estudo Monocêntrico sobre Causas, Consequências e Estratégias de Prevenção

Introduction: Workplace violence is one of the main risk factors in the professional world. Healthcare workers are at higher risk when compared to other sectors. Our study aimed to characterize physical and verbal violence in a public hospital and to define occupational health prevention and surveillance strategies. Material and Methods: Single center observational cross-sectional study, carried amongst healthcare workers in a public hospital in Lisbon. A qualitative survey was carried out through six in-depth interviews. A quantitative survey was carried through questionnaires delivered to 32 workers. A significance level of 5% was accepted in the assessment of statistical differences. The Mann-Whitney test and the Fisher’s exact test were used to calculate p values. Results: The main results are: (1) 41 violence incidents were reported in the quantitative phase; (2) 5/21 [23.81%] victims notified the incident to the occupational health department; (3) 18/21 [85.71%] victims reported a permanent state of hypervigilance; (4) 22/28 [78.57%] participants self-reported poor or no familiarity with internal reporting procedures; (5) 24/28 [85.71%] participants believed it is possible to minimize workplace violence. Discussion: Workplace violence is favored by unrestricted access to working areas, absence of security guards and police officers or scarce intervention. The low notification rate contributes to organizational lack of action. The state of hypervigilance reported in our study reflects the negative effects of threatening occupational stressors on mental health. Conclusion: Our results show that workplace violence is a relevant risk factor that significantly impacts workers’ health in a noxious manner, deserving a tailored occupational health approach whose priority areas and strategies have been determined.Introdução: A violência no local de trabalho é um dos principais fatores de risco no mundo do trabalho. Os trabalhadores da saúde apresentam um risco superior. O nosso estudo teve como objetivo caracterizar a violência física e verbal num hospital público e definir estratégias de prevenção e vigilância em saúde ocupacional. Material e Métodos: Estudo observacional transversal monocêntrico, conduzido num hospital público em Lisboa com trabalhadores da saúde. Foi realizado um inquérito qualitativo com entrevistas em profundidade a seis trabalhadores e um inquérito quantitativo com questionários a 32 trabalhadores. Aceitou-se um nível de significância de 5% na avaliação das diferenças estatísticas. O teste de Mann-Whitney e o teste exato de Fisher foram usados para calcular os valores de p. Resultados: Os principais resultados são: (1) 41 episódios reportados na fase quantitativa; (2) 5/21 [23,81%] vítimas notificaram o incidente; (3) 18/21 [85.71%] vítimas reportaram estados de hipervigilância permanente; (4) 22/28 [78,57%] participantes não conheciam ou conheciam mal os procedimentos de notificação; (5) 24/28 [85,71%] consideravam possível minimizar o problema. Discussão: A violência é favorecida pelo acesso livre às zonas de trabalho, ausência de agentes de segurança e polícia ou falta da respetiva intervenção. A baixa notificação contribui para a ausência de medidas organizacionais. O estado de hipervigilância relatado reflete o efeito prejudicial da exposição a fontes de stress e ameaça. Conclusão: A violência no local de trabalho é um fator de risco relevante, com impacto negativo na saúde dos trabalhadores e merece uma abordagem individualizada no âmbito da saúde ocupacional, cujas áreas e estratégias prioritárias foram definidas neste estudo. Palavras-chave: Fatores de Risco Profissionais; Prevenção; Saúde Ocupacional; Trabalhadores da Saúde; Violência no Local de trabalho.info:eu-repo/semantics/publishedVersio