The Lyman-alpha Forest at z~4: Keck HIRES Observations of Q 0000-26

This paper describes a study of the Lyman-alpha forest absorption clouds along the quasar sightline Q0000-26 (zem=4.1). The spectrum was obtained with the High Resolution Spectrometer on the 10m Keck telescope. We derive accurate H I column density and Doppler width distributions for the clouds from Voigt profile fitting. We also analyze simulated Lyman-alpha forest spectra of matching characteristics in order to gauge the effects of line blending/blanketing and noise in the data. The results are compared with similar studies at lower redshifts in order to study any possible evolution in the clouds' properties. We also estimate the mean intensity of the UV background at z=4 from an analysis of the proximity effect.Comment: plain TeX containing 23 PS pages, 3 PS tables, and 9 PS figures, ApJ, Dec 1, 1996 issue replacing an earlier version which contains an corrupted table

The Del1 deposition domain can immobilize 3α-hydroxysteroid dehydrogenase in the extracellular matrix without interfering with enzymatic activity

Developing methods that result in targeting of therapeutic molecules in gene therapies to target tissues has importance, as targeting can increase efficacy and decrease off target-side-effects. Work from my laboratory previously showed that the extracellular matrix protein Del1 is organized in the extracellular matrix (ECM) via the Del1 deposition domain (DDD). In this work, a fusion protein with DDD was made to assay the ability to immobilize an enzyme without disrupting enzymatic function. A prostatic cancer-derived cell line LNCap that grows in an androgen-dependent manner was used with 3α-hydroxysteroid dehydrogenase (3 αHD), which catalyzes dihydrotestosterone (DHT). Plasmids encoding a 3αHD:DDD fusion were generated and transfected into cultured cells. The effects of 3αHD immobilized in the ECM by the DDD were evaluated by monitoring growth of LNCap cells and DHT concentrations. It was demonstrated that the DDD could immobilize an enzyme in the ECM without interfering with function

The Aspherical Properties of the Energetic Type Ic SN 2002ap as Inferred from its Nebular Spectra

The nebular spectra of the broad-lined, SN 1998bw-like Type Ic SN 2002ap are studied by means of synthetic spectra. Two different modelling techniques are employed. In one technique, the SN ejecta are treated as a single zone, while in the other a density and abundance distribution in velocity is used from an explosion model. In both cases, heating caused by gamma-ray and positron deposition is computed (in the latter case using a Monte Carlo technique to describe the propagation of gamma-rays and positrons), as is cooling via forbidden-line emission. The results are compared, and although general agreement is found, the stratified models are shown to reproduce the observed line profiles much more accurately than the single-zone model. The explosion produced ~ 0.1 Msun of 56Ni. The distribution in velocity of the various elements is in agreement with that obtained from the early-time models, which indicated an ejected mass of ~ 2.5 Msun with a kinetic energy of 4 x 10^{51} erg. Nebular spectroscopy confirms that most of the ejected mass (~ 1.2 Msun) was oxygen. The presence of an oxygen-rich inner core, combined with that of 56Ni at high velocities as deduced from early-time models, suggests that the explosion was asymmetric, especially in the inner part.Comment: 24 pages, 6 figures, 2 Tables. Accepted by the Astrophysical Journa

The Optical/Near-Infrared Light Curves of SN 2002ap for the First 140 Days after Discovery

Supernova (SN) 2002ap in M74 was observed in the $UBVRIJHK$ bands for the first 40 days following its discovery (2002 January 29) until it disappeared because of solar conjunction, and then in June after it reappeared. The magnitudes and dates of peak brightness in each band were determined. While the rate of increase of the brightness before the peak is almost independent of wavelength, the subsequent rate of decrease becomes smaller with wavelength from the $U$ to the $R$ band, and is constant at wavelengths beyond $I$. The photometric evolution is faster than in the well-known ``hypernovae'' SNe~1998bw and 1997ef, indicating that SN 2002ap ejected less mass. The bolometric light curve of SN 2002ap for the full period of observations was constructed. The absolute magnitude is found to be much fainter than that of SN 1998bw, but is similar to that of SN 1997ef, which lies at the faint end of the hypernova population. The bolometric light curve at the early epochs was best reproduced with the explosion of a C+O star that ejects 2.5~M_\sun with kinetic energy $E_{\rm K}=4\times 10^{51}~{\rm ergs}$. A comparison of the predicted brightness of SN 2002ap with that observed after solar conjunction may imply that $\gamma$-ray deposition at the later epochs was more efficient than in the model. This may be due to an asymmetric explosion.Comment: 15 pages, 6 figures, quality of figure1 is reduced for smaller filesize, accepted for publication in Ap

A low upper-limit on the lithium isotope ratio in HD140283

We have obtained a high-S/N (900-1100), high-resolving-power (R=95000) spectrum of the metal-poor subgiant HD 140283 in an effort to measure its 6Li/7Li isotope ratio. From a 1-D atmospheric analysis, we find a value consistent with zero, 6Li/7Li = 0.001, with an upper limit of 6Li/7Li < 0.026. This measurement supersedes an earlier detection (0.040 +/- 0.015(1sigma)) by one of the authors. HD 140283 provides no support for the suggestion that Population II stars may preserve their 6Li on the portion of the subgiant branch where 7Li is preserved. However, this star does not defeat the suggestion either; being at the cool end of subgiant branch of the Spite plateau, it may be sufficiently cool that 6Li depletion has already set in, or the star may be sufficiently metal poor that little Galactic production of 6Li had occurred. Continued investigation of other subgiants is necessary to test the idea. We also consider the implications of the HD 140283 upper limit in conjunction with other measurements for models of 6Li production by cosmic rays from supernovae and structure formation shocks.Comment: 8 pages, 4 figures; accepted for publication in Astronomy and Astrophysic

Chemical composition of carbon-rich, very metal-poor subgiant LP625-44 observed with the Subaru/HDS

We have obtained a high resolution (R~90,000) spectrum of the carbon- and s-process-element-rich, very metal-poor ([Fe/H]=-2.7) subgiant LP625-44, as well as that of HD140283 (a metal-poor subgiant with normal abundance ratio) for comparison, with the High Dispersion Spectrograph (HDS) for the Subaru Telescope for detailed abundance study. The oxygen abundance derived from the O I triplet around 7770A is uncertain, but the excess of oxygen in LP625-44 seems remarkable (perhaps by nearly a factor 10), in comparison with that of HD140283 derived from the same lines. The Na enhancement in LP625-44 is by about a factor 50, suggesting hydrogen burning in the 22Ne-rich layer in an asymptotic giant branch star which produces the abundance pattern of this object. In our new spectrum of LP625-44, the Pb I lambda 3683A line has been detected, as well as the Pb I lambda 4057A line which has already been studied, confirming the Pb abundance (log epsilon(Pb)~1.9) derived by the previous work. The abundance ratio of s-process elements at the second peak (e.g., La, Ce and Nd) to that at the third peak (Pb) in LP 625-44 is significantly higher (by a factor 5) than that in other three s-process element-rich objects recently studied by van Eck et al.. Recent theoretical works have modeled the s-process nucleosynthesis in the radiative layer of asymptotic giant branch stars in the inter-pulse phase, and the above results means that these processes produced a large scatter in the abundance ratios. Another possiblity is that different processes (e.g., s-process nucleosynthesis during thermal pulses) have contributed to heavy elements in the early Galaxy.Comment: 65 pages, 11 figures, to appear in PAS