Factores trombogénicos sistémicos en paciente con síndrome coronario agudo con cinecoronariografía normal y patológica

En la fisiopatología del síndrome coronario agudo (SCA) sin evidencia de lesión ateromatosa oclusiva, podría participar un estado de hipertrombogenicidad sanguínea, generado por factores trombogénicos sistémicos, como los factores de riesgo cardiovascular y los que intervienen en el balance coagulación-anticoagulación, fibrinolisis y formación de fibrina. Objetivo: Estudiar y comparar los factores trombogénicos sistémicos en pacientes con SCA y cinecoronariografía (CCG) normal y patológica.In the pathophysiology of acute coronary syndrome (ACS) without evidence of occlusive atherosclerotic lesion, could participate a state of blood hipertrombogenicidad generated by systemic thrombogenic factors such as cardiovascular risk factors and those involved in the balance coagulation-anticoagulation, fibrinolysis and fibrin formation. Objective: Study and compare systemic thrombogenic factors in patients with ACS and normal and pathological coronary angiography (GCC).Fil: Testasecca, E.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Testasecca, A.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Maneschi, E.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Fragapane, P.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de InmunologíaFil: Diumenjo, M. S.. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Cátedra de Inmunologí

∞-Laplacian Obstacle Problems in Fractal Domains

In this paper we deal with p-Laplacian and ∞-Laplacian obstacle problems in fractal and pre-fractal domains, analyzing both the asymptotic behavior and the issue of the uniqueness of the solutions. Moreover, we consider numerical approximations, we state uniform estimates for FEM-approximate solutions and we discuss about the rate of vanishing of the approximation error

Materiali Compositi Ibridi Resistenti al Fuoco

La sempre crescente richiesta nell\u2019ambito della progettazione strutturale aeronautica/aerospaziale di materiali aventi elevate perfomance meccaniche, ha determinato negli ultimi decenni la diffusione dei materiali compositi a matrice polimerica (Polymer Matrix Composites, PMCs) rinforzati prevalentemente con fibre di carbonio (Carbon Fiber Reinforced Plastic, CFRP). Le principali limitazioni nell\u2019uso di tali compositi sono dovute all\u2019elevata sensibilit\ue0 agli agenti ambientali ed alle basse temperature di esercizio; inoltre, tali materiali mal sopportano l\u2019esposizione al fuoco e ci\uf2 per via della facile incendiabilit\ue0 non solo della matrice ma anche delle fibre. Al fine di mettere a punto un composito che unisca alle performance strutturali dei CFRP, una buona resistenza alle alte temperature e al fuoco, nel presente lavoro si \ue8 studiato l\u2019uso di un composito ibrido costituito da un laminato CFRP unito a lamine di composito a matrice ceramica (Ceramic Matrix Composite, CMC). Preliminari verifiche sperimentali eseguite per la messa a punto del modello e successive simulazioni numeriche hanno consentito di verificare la bont\ue0 della soluzione proposta

The Reinforcement Effect of Strain Gauges Embedded in Low Modulus Material

The reinforcement effect of electrical resistance strain gauges is well-described in the literature, especially for strain gauges installed on surface. This paper considers the local reinforcement effect of strain gauges embedded within low Young modulus materials. In particular, by using a simple theoretical model, already used for strain gauges installed on the surface, it proposes a simple formula that allows the user to evaluate the local reinforcement effect of a generic strain gauge embedded on plastics, polymer composites, etc. The theoretical analysis has been integrated by numerical and experimental analyses, which confirmed the reliability of the proposed model

The mechanisms controlling ribosomal protein L1 pre-mRNA splicing are maintained in evolution and rely on conserved intron sequences.

Sequences corresponding to the third intron of the X.laevis L1 ribosomal protein gene were isolated from the second copy of the X.laevis gene and from the single copy of X.tropicalis. Sequence comparison revealed that the three introns share an unusual sequence conservation which spans a region of 110 nucleotides. In addition, they have the same suboptimal 5' splice sites. The three introns show similar features upon oocyte microinjection: they have very low splicing efficiency and undergo the same site specific cleavages which lead to the accumulation of truncated molecules. Computer analysis and RNAse digestions have allowed to assign to the conserved region a specific secondary structure. Mutational analysis has shown that this structure is important for conferring the cleavage phenotype to these three introns. Competition experiments show that the cleavage phenotype can be prevented by coinjection of excess amounts of homologous sequences

A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA.

We report that the third intron of the L1 ribosomal protein gene of Xenopus laevis encodes a previously uncharacterized small nucleolar RNA that we called U16. This snRNA is not independently transcribed; instead it originates by processing of the pre-mRNA in which it is contained. Its sequence, localization and biosynthesis are phylogenetically conserved: in the corresponding intron of the human L1 ribosomal protein gene a highly homologous region is found which can be released from the pre-mRNA by a mechanism similar to that described for the amphibian U16 RNA. The presence of a snoRNA inside an intron of the L1 ribosomal protein gene and the phylogenetic conservation of this gene arrangement suggest an important regulatory/functional link between these two components