A Minimum-Labeling Approach for Reconstructing Protein Networks across Multiple Conditions

The sheer amounts of biological data that are generated in recent years have driven the development of network analysis tools to facilitate the interpretation and representation of these data. A fundamental challenge in this domain is the reconstruction of a protein-protein subnetwork that underlies a process of interest from a genome-wide screen of associated genes. Despite intense work in this area, current algorithmic approaches are largely limited to analyzing a single screen and are, thus, unable to account for information on condition-specific genes, or reveal the dynamics (over time or condition) of the process in question. Here we propose a novel formulation for network reconstruction from multiple-condition data and devise an efficient integer program solution for it. We apply our algorithm to analyze the response to influenza infection in humans over time as well as to analyze a pair of ER export related screens in humans. By comparing to an extant, single-condition tool we demonstrate the power of our new approach in integrating data from multiple conditions in a compact and coherent manner, capturing the dynamics of the underlying processes.Comment: Peer-reviewed and presented as part of the 13th Workshop on Algorithms in Bioinformatics (WABI2013

Disaster-Resilient Control Plane Design and Mapping in Software-Defined Networks

Communication networks, such as core optical networks, heavily depend on their physical infrastructure, and hence they are vulnerable to man-made disasters, such as Electromagnetic Pulse (EMP) or Weapons of Mass Destruction (WMD) attacks, as well as to natural disasters. Large-scale disasters may cause huge data loss and connectivity disruption in these networks. As our dependence on network services increases, the need for novel survivability methods to mitigate the effects of disasters on communication networks becomes a major concern. Software-Defined Networking (SDN), by centralizing control logic and separating it from physical equipment, facilitates network programmability and opens up new ways to design disaster-resilient networks. On the other hand, to fully exploit the potential of SDN, along with data-plane survivability, we also need to design the control plane to be resilient enough to survive network failures caused by disasters. Several distributed SDN controller architectures have been proposed to mitigate the risks of overload and failure, but they are optimized for limited faults without addressing the extent of large-scale disaster failures. For disaster resiliency of the control plane, we propose to design it as a virtual network, which can be solved using Virtual Network Mapping techniques. We select appropriate mapping of the controllers over the physical network such that the connectivity among the controllers (controller-to-controller) and between the switches to the controllers (switch-to-controllers) is not compromised by physical infrastructure failures caused by disasters. We formally model this disaster-aware control-plane design and mapping problem, and demonstrate a significant reduction in the disruption of controller-to-controller and switch-to-controller communication channels using our approach.Comment: 6 page

Analisis Kepuasan Pelanggan pada Hotel Resty Menara Pekanbaru

Customer satisfaction is a situation where the wishes, expectations and customer requirements are met. Customer satisfaction is defined as a form of consumer sentiment after comparing with their expectations. Customer expectations on satisfaction, which is always changing demands company professionality, because satisfaction is indeed intercedes to improve quality ofservice.Based on the analysis to the Cartesian diagram Importance and Performance Analysis, there is one attribute that is entered into the first quadrant(Priority) which indicates the level of importance of these attributes considered important by consumers, but the performance shown by this attribute is considered low or have not been maximal, that was attribute 8 namelycompleteness and cleanliness of the rooms. There are three attributes that go intoquadrant II (Maintain Achievement) which shows attributes that are consideredimportant by consumers and the level of performance in line with expectationsconsumers. These Atribut were Attributes 2 (Health and Quality Menu), Attribute3 (Support Facility) and attribute 9 (Equipment Food) .there were three attributesinto the third quadrant (lower priority) which shows attributes that are considered less important by consumers and the level of performance in reality is not very good, the attribute were attribute 1 (interior room), attribute 4(friendliness and sincerity), attribute 5 (fast response) and attribute 7 (standard room) . There was 1 attributes that go into quadrant IV (redundant) that showedlittle or no service attributes are important but the level of performance isconsidered excessive, the attributes was attribute 6 (Responsive and solution)Keyword : Cunsomers Satisfaction , Importance and Performance Analysis, IP

Pengaruh Pembelajaran Fisika Berbasis Al-qur'an Terhadap Sikap Spiritual Siswa Kelas X SMA Negeri 2 Banda Aceh

The aims of this study is determine the effect of learning physics-based Al-Qur'an spiritual attitude towards students. The population in this study were students of class X of Mathematics and Science in SMA 2 Banda Aceh the school year 2015/2016 consists of 5 classes with totaling 122 students. The sample of this study is the class X MIPA 4 as an experimental class taught by physics-based learning the Qur'an and the class X MIPA 5 as the control class is taught based learning without the Qur'an. This type of research is experimental research with quantitative methods. The data collection is done by using observation and self-assessment sheet. Data processing observation sheet and spiritual attitude of self-assessment of students using statistical tests such as t test was first tested for normality and homogeneity. The results of data analysis that the value t = 10,46 while the value table = 1,68 therefore based on the criteria of testing hypotheses, reject Ho if thitung> ttable, Because thitung> ttable then reject Ho. Based on these results it can be concluded that learning physics-based Al-Qur'an better than learning-based physics without the Qur'an in improving the spiritual attitude of the students, it indicates that there is an influence of learning physics-based Al-Qur'an on attitudes spiritual class X SMAN 2 Banda Aceh