95 research outputs found
Aspecte clinico-morfologice Ʈn chistul de arc II branchial la copil
Cazul prezentat ilucideazÄ principiile de diagnostic Či tratament chirurgical Ć®n chistul de arc II branchial la copii, autorii
descriind Či modificÄrile morfopatologice caracteristice Ć®n aceastÄ formaČiune malformativÄ.
Raritatea cazului prezentat are ca scop de a atenČiona necesitatea unui indice de suspiciune sporit Ć®n cazurile unor
formaČiuni cervicale laterale pentru un diagnostic adecvat Či un tratament corespunzÄtor, examenul histologic al piesei
de rezecČie fiind obligator.The case illustrates the principles of diagnosis and treatment of branchial second arch cyst in children, the authors
also described the morphopathological changes found in this malformative formation. The rarity of the presented case
aims to warn of the need for an increased index of suspicion in cases of lateral cervical formations for proper diagnosis
and treatment, the histological examination of the resection piece being mandatory
ParticularitÄČile proceselor regenerative Ć®n reconstrucČia defectelor diafragmatice cu alogrefe decelularizate de pericard porcin Ć®n model experimental
Actualmente se depun eforturi considerabile Ć®n elaborarea unor materiale biologice decelularizate ca alternativÄ de corecČie
chirurgicalÄ a defectelor diafragmatice.
Scopul acestui studiu a fost evaluarea eficienČei, siguranČei Či particularitÄČilor proceselor de regenerare Či remodelare tisularÄ ale
alogrefelor decelularizate de pericard porcin crioprezervate, utilizate Ć®n reconstrucČia defectelor diafragmatice, create chirurgical Ć®n
model experimental la porci.
Lotul de studiu a inclus 6 purcei cu greutatea de 10 kg, supuČi laparotomiei subcostale stĆ¢ngi cu reconstrucČia defectului
diafragmatic, creat chirurgical, cu grefe decelularizate de pericard porcin (lotul 1 - 3 animale) Či peritoneu porcin (lotul 2 - 3
animale).
Exameul radilogic efectuat Ć®n loul 1 la 15 zile postoperator a stabilit o configuraČie normalÄ a neohemidiafragmului creat, la a 60 zi
postoperator fiind documentatÄ eventraČia nesemnificativÄ a neohemidiafragmului. Ćn lotul 2 la a 15 zi postoperator a fost observatÄ o
eventraČie neĆ®nsemnatÄ a neohemidiafragmului, ulterior, ambele animale acestui lot decedĆ®nd subit la a 54 Či a 60 zi postoperator din
cauza dehiscenČei grefei.
Ćn lotul I au fost observate zone cu o fibrilogenezÄ atipicÄ (malformativÄ) care se evidenČiau printr-un aspect multichistic sau lacunarcavitar, cu suprafeČe interne tapetate cu epiteliu mezotelial peritoneal unistratificat aplatizat fÄrÄ aspecte de activitate mitoticÄ.
FormaČiunea cavitar-chisticÄ putea fi Či o pseudotumorÄ chisticÄ cu septuri mai subČiri, cu o carcasÄ redusÄ din fibre de colagen. La
animalele lotului 2 Ć®n ambele cazuri s-a constatat un hemidiafragm cu defect persistent determinat de reabsorbČia parČialÄ a
materialului biologic, necÄtĆ®nd cÄ putea fi observat Či zone de Česut neoformat.
AČadar, grefele decelularizate de peritoneu porcin utilizate Ć®n reconstrucČia chirurgicalÄ a diafragmului sunt caracterizate de o
biorezistenČÄ redusÄ, care poate contribui la reabsorbČia parČialÄ a acestui material biologic cu dezvoltarea unor complicaČii grave.
Grefele decelularizate de pericard au o biorezistenČÄ acceptabilÄ comparativ cu cele de peritoneu porcin, aceste date sugend
necesitatea unor studii suplimentare pe termen lung, care ar avea ca scop obČinerea unor rezultate mai durabile.Considerable efforts are currently underway in the development of decellularized biologic materials as an alternative to surgical
correction of diaphragmatic defects.
The aim of this study was to evaluate the efficiency, safety and particularities of tissue regeneration and remodeling processes of
allograft decellularized cryopreserved porcine pericardium, used in the reconstruction of diaphragmatic defects, surgically created in
experimental model in pigs.
The study group included 6 pigs weighing 10 kg, subjected to left subcostal laparotomy with surgical reconstruction of
diaphragmatic defect, with decellularized grafts of porcine pericardium (1-3 animals) and porcine peritoneum (group 2- 3 animals).
The radilogic examination performed in group 1 at 15 days postoperatively a normal configuration of the neohemidiaphragm created,
at 60 postoperative day being documented the insignificant eventration of neohemidiaphragm. In group 2 to 15 postoperatively, a
slight incidence of neohemidiaphragm was observed, after which both animals of this group died suddenly at 54 and 60 days
postoperatively due to graft dehiscence.
In 2 cases areas with atypical (malformative) fibrillogenesis were observed, which were evidenced by a multicystic or lacunar-cavity
aspect, with internal surfaces covered with unistratified peritoneal mesothelial epithelium flattened without aspects of mitotic
activity. The mesothelial cavity-cystic aspect has also been shown on border, in some cavities being present fibro-epithelial
conjunctival micro-polyps. The cavity-cyst formation could also be a cystic pseudotumor with thinner septa, with a reduced collagen
fiber housing. In the animals of lot 2, in both cases, there was a hemidiaphragm with persistent defect determined by the partial
reabsorption of the biological material, although neoformed tissue areas could be observed.
Therefore, decellularized porcine peritoneum grafts used in surgical reconstruction of the diaphragm are characterized by a low
bioresistence which can contribute to the partial reabsorption of this biological material with the development of serious
complications. Decellularized grafts of porcine pericardium have an acceptable bioresistence compared to porcine peritoneum, and
this data suggests the need for further long-term studies that would seek to achieve more sustainable outcomes
Influence of external factors on the composition and therapeutic efficiency of propolis
Universitatea de Stat de MedicinÄ Či Farmacie āNicolae TestemiÅ£anuā din Republica Moldova, Institutul de Chimie afiliat Academiei de ČtiinÅ£e al Republicii Moldova, ChiČinÄu, Republica Moldova, Universitatea de ČtiinÅ£e Agricole Či MedicinÄ VeterinarÄ, Cluj-Napoca, RomĆ¢nia, Universitatea AgrarÄ de Stat din Moldova, ChiČinÄu, Republica MoldovaAbstract. From therapeutic point of view, propolis is one of the most valuable bee products, which proves its use
in various pharmaceutical forms, and further research of this product worldwide. However the complex and diverse
composition requires a complex study of both propolis and the factors that lead to the modification of the composition
and respectively inevitably to the change of the therapeutic properties. This paper is a synthesis of the
effects of the use of herbicides and insecticides on the composition and therapeutic properties of propolis. It was
established that the presence of certain herbicides and insecticides propolis samples collected in different geographic
areas, as is concluded to decrease the effect of the presence of the therapeutic properties of propolis in the
presence of polluting factors mentioned above.Rezumat. Din punct de vedere terapeutic, propolisul reprezintÄ una dintre cele mai valoroase substanÅ£e biologic
active apicole, fapt dovedit de utilizarea lui tot mai largÄ Ć®n diverse prescripÅ£ii Či forme farmaceutice, Či studiul lui
centrat, reluat Ć®n pandemie, la nivel mondial. CompoziÅ£ia complexÄ Či diversÄ, necesitÄ un studiu la fel de complex,
atĆ¢t al propolisului, cĆ¢t Či al factorilor ce pot duce la modificarea compoziÅ£iei, Či respectiv, la schimbarea potenÅ£ialului
terapeutic. Lucrarea reprezintÄ o sintezÄ prioritar axatÄ pe rezultatele studiilor efectelor utilizÄrii erbicidelor
Či insecticidelor asupra compoziÅ£iei Či potenÅ£ialului terapeutic al propolisului. Astfel, prezenÅ£a unor erbicide Či insecticide
Ć®n mostrele de propolis colectat Ć®n diferite zone geografice Či climacterice, influenÅ£eazÄ direct compoziÅ£ia
propolisului, condiÅ£ionĆ¢nd diminuarea substanÅ£ialÄ a potenÅ£ialului lui terapeutic
Body Shaping and Volume Restoration: The Role of Hyaluronic Acid
Driven by the rising popularity of minimally invasive techniques, the demand for cosmetic procedures is increasing. Cosmetic body-shaping procedures can be categorized into those that remove tissue and those that add volume. This review focuses on the latter of these categories, particularly on the use of resorbable hyaluronic acid gels specifically developed for minimally invasive volume enhancement. Pilot studies of hyaluronic acid involving its injection to contour various body deformities and its recent use in female breast augmentation are discussed. Injectable hyaluronic acid is effective and well tolerated. It represents an attractive treatment option for volume restoration or augmentation by providing predictable long-lasting results after minimally invasive administration. Alternative treatment options for volume enhancement also are summarized including fat transfer, silicone implants, and the use of injectable nonresorbable products such as silicone, polyalkylimide, and polyacrylamide gels. As patients continue to opt for nonsurgical procedures that offer predictable results, the development of minimally invasive products such as hyaluronic acid is increasingly important
Life Cycle Management of Infrastructures
By definition, life cycle management (LCM) is a framework āof concepts, techniques, and procedures to address environmental, economic, technological, and social aspects of products and organizations in order to achieve continuous āsustainableā improvement from a life cycle perspectiveā (Hunkeler et al.\ua02001). Thus, LCM theoretically integrates all sustainability dimensions, and strives to provide a holistic perspective. It also assists in the efficient and effective use of constrained natural and financial resources to reduce negative impacts on society (Sonnemann and Leeuw\ua02006; Adibi et al.\ua02015). The LCM of infrastructures is the adaptation of product life cycle management (PLM) as techniques to the design, construction, and management of infrastructures. Infrastructure life cycle management requires accurate and extensive information that might be generated through different kinds of intelligent and connected information workflows, such as building information modeling (BIM)
Weekly Intra-Amniotic IGF-1 Treatment Increases Growth of Growth-Restricted Ovine Fetuses and Up-Regulates Placental Amino Acid Transporters
Frequent treatment of the growth-restricted (IUGR) ovine fetus with intra-amniotic IGF-1 increases fetal growth. We aimed to determine whether increased growth was maintained with an extended dosing interval and to examine possible mechanisms. Pregnant ewes were allocated to three groups: Control, and two IUGR groups (induced by placental embolization) treated with weekly intra-amniotic injections of either saline (IUGR) or 360 Āµg IGF-1 (IGF1). IUGR fetuses were hypoxic, hyperuremic, hypoglycemic, and grew more slowly than controls. Placental glucose uptake and SLC2A1 (GLUT2) mRNA levels decreased in IUGR fetuses, but SLC2A3 (GLUT3) and SLC2A4 (GLUT4) levels were unaffected. IGF-1 treatment increased fetal growth rate, did not alter uterine blood flow or placental glucose uptake, and increased placental SLC2A1 and SLC2A4 (but not SLC2A3) mRNA levels compared with saline-treated IUGR animals. Following IGF-1 treatment, placental mRNA levels of isoforms of the system A, y+, and L amino acid transporters increased 1.3 to 5.0 fold, while the ratio of phosphorylated-mTOR to total mTOR also tended to increase. Weekly intra-amniotic IGF-1 treatment provides a promising avenue for intra-uterine treatment of IUGR babies, and may act via increased fetal substrate supply, up-regulating placental transporters for neutral, cationic, and branched-chain amino acids, possibly via increased activation of the mTOR pathway
Social norms towards smoking and electronic cigarettes among adult smokers in seven European Countries: Findings from the EUREST-PLUS ITC Europe Surveys
Introduction:
This study explores whether current smokersā social norms towards smoking and electronic cigarettes (e-cigarettes) vary across seven European countries alongside smoking and e-cigarette prevalence rates. At the time of surveying, England had the lowest current smoking prevalence and Greece the highest. Hungary, Romania and Spain had the lowest prevalence of any e-cigarette use and England the highest. //
Methods:
Respondents were adult (ā„18 years) current smokers from the 2016 EUREST-PLUS ITC (Romania, Spain, Hungary, Poland, Greece, Germany) and ITC 4CV England Surveys (N=7779). Using logistic regression, associations between country and (a) smoking norms and (b) e-cigarette norms were assessed, adjusting for age, sex, income, education, smoking status, heaviness of smoking, and e-cigarette status. //
Results:
Compared with England, smoking norms were higher in all countries: reporting that at least three of five closest friends smoke (19% vs 65ā84% [AOR=6.9ā24.0; HungaryāGreece]), perceiving that people important to them approve of smoking (8% vs 14ā57% [1.9ā51.1; SpaināHungary]), perceiving that the public approves of smoking (5% vs 6ā37% [1.7ā15.8; SpaināHungary]), disagreeing that smokers are marginalised (9% vs 16ā50% [2.3ā12.3; PolandāGreece]) except in Hungary. Compared with England: reporting that at least one of five closest friends uses e-cigarettes was higher in Poland (28% vs 36% [2.7]) but lower in Spain and Romania (28% vs 6ā14% [0.3ā0.6]), perceiving that the public approves of e-cigarettes was higher in Poland, Hungary and Greece (32% vs 36ā40% [1.5ā1.6]) but lower in Spain and Romania in unadjusted analyses only (32% vs 24ā26%), reporting seeing e-cigarette use in public at least some days was lower in all countries (81% vs 12ā55% [0.1ā0.4]; SpaināGreece). //
Conclusions:
Smokers from England had the least pro-smoking norms. Smokers from Spain had the least pro-e-cigarette norms. Friend smoking and disagreeing that smokers are marginalised broadly aligned with country-level current smoking rates. Seeing e-cigarette use in public broadly aligned with countrylevel any e-cigarette use. Generally, no other norms aligned with product prevalence
Smoking in public places in six European countries: Findings from the EUREST-PLUS ITC Europe Survey
Introduction: Surveillance of tobacco consumption in public places is an important measure to evaluate the impact of tobacco control interventions over time. The objective of this study was to estimate the prevalence of smoking as seen by smokers and their smoking behaviour in public places, in six European countries. Methods: We used baseline data of the International Tobacco Control Six European countries (ITC 6E) Survey, part of the EUREST-PLUS Project, conducted in 2016 in national representative samples of about 1000 adult smokers aged 18 years and older in Germany, Greece, Hungary, Poland, Romania and Spain. For each setting (workplaces, restaurants, bars/pubs and discos) participants were asked whether they had seen someone smoking during their last visit there and whether they too had smoked there. We report the overall and by-country weighted prevalence of seeing someone smoking and the smokersā own smoking behaviour at each setting. We also assess the relationship between seeing someone smoking and smoking themselves at these settings. Results: The prevalence of smoking as seen by smokers was 18.8% at workplaces, with high variability among countries (from 4.7% in Hungary to 40.8% in Greece). Among smokers visiting leisure facilities in the last year, during their last visit 22.7% had seen someone smoking inside restaurants and 12.2% had smoked themselves there, while for bars/pubs the corresponding prevalences were 33.9% and 20.4%, and inside discos 44.8% and 34.8%. Conclusions: Smoking is still prevalent at leisure facilities, particularly at discos in Europe, with high variability among countries. More extensive awareness campaigns and stricter enforcement are needed to increase the compliance of smokefree regulations, especially in leisure facilities
Patterns of tobacco use, quit attempts, readiness to quit and self-efficacy among smokers with anxiety or depression: Findings among six countries of the EUREST-PLUS ITC Europe Surveys
Introduction: We compared smoking behaviors, past quit attempts, readiness to quit and beliefs about quitting among current cigarette smokers with probable anxiety or depression (PAD) to those without PAD, from six European Union (EU) Member States (MS). Methods: A nationally representative cross-sectional sample of 6011 adult cigarette smokers from six EU MS (Germany, Greece, Hungary, Poland, Romania, Spain) was randomly selected through a multistage cluster sampling design in 2016. Respondents were classified as having PAD based on self-reported current diagnosis or treatment for anxiety or depression, or a positive screen for major depression, according to a validated two-item instrument. Sociodemographic characteristics, patterns of tobacco use, past quitting, readiness to quit, self-efficacy and beliefs about quitting were assessed for patients with and without PAD. Logistic regression was used to examine predictors of PAD. All analyses were conducted using the complex samples package of SPSS. Results: Among smokers sampled, 21.0% (95% CI: 19.3ā22.9) were identified as having PAD. Logistic regression analyses controlling for socioeconomic variables and cigarettes smoked per day found smokers with PAD were more likely to have made an attempt to quit smoking in the past (AOR=1.48; 95% CI: 1.25ā1.74), made a quit attempt in the last 12 months (AOR=1.75; 95% CI: 1.45ā2.11), and report lower self-efficacy with quitting (AOR=1.83; 95% CI: 1.44ā2.32) compared to smokers without PAD. Additionally, it was found that individuals with PAD were more likely to report having received advice to quit from a doctor or health professional and having used quitline support as part of their last quit attempt. Conclusions: Smokers with PAD report a greater interest in quitting in the future and more frequent failed quit attempts than smokers without PAD; however, the high rates of untreated anxiety or depression, nicotine dependence, low confidence in the ability to quit, infrequent use of cessation methods, as well as socioeconomic factors may make quitting difficult
Studies on enhancing operational stability of a reusable laccase-based biosensor probe for detection of ortho-substituted phenolic derivatives
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