Cephalometric analysis of adaptations after lengthening of the masseter muscle in adult rhesus monkeys, Macaca mulatta

This relationship between the function of the muscles of mastication and craniofacial form was investigated in young adult monkeys by increasing the functional length of the elevator muscles of the mandible non-invasively by a bite-opening splint cemented to the maxillary dentition. The major adaptations to increased vertical dimension were (1) marked superior and some anterior displacement of the maxillary complex, (2) dental intrusion and (3) rotation of the mandible. These alterations produced a shortening of the lengthened masseter muscle, i.e. a reduction in the amount of muscle stretch brought about by the appliance. Migration of the masseteric insertion along the ramus did not contribute significantly to the pattern of adaptation. The role of the masseter muscle in craniofacial adaptations to altered vertical dimension was determined by detaching and re-attaching the insertion of the masseter muscle in one group of experimental animals. The myotomized monkeys experienced significantly less anterior displacement of the maxilla than the non-myotomized monkeys, indicating that the surgery may have lessened some of the anteriorly-directed distracting forces of the lengthened masseter. Masseter myotomy alone was not sufficient to eliminate the vertically-directed distracting forces of the remainder of the mandibular elevator muscles brought about by increasing the vertical dimension of the lower face.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25433/1/0000883.pd

Cephalometric analysis of condylar adaptations to altered mandibular position in adult rhesus monkeys, Macaca mulatta

Morphological adaptation to altered position of the mandible was investigated in 19 young adult rhesus monkeys (n = 10 experiment and 9 control). The experimental animals had a bite-splint cemented to the maxillary dentition which opened the bite interincisally by 15 mm and was worn continuously for 48 weeks. Lateral radiographic cephalograms were taken prior to the experiment and at 12-week intervals thereafter. Computerized cephalometry, facilitated by the use of radio-opaque bone markers, was used to assess changes in mandibular position and morphology. An immediate effect of the bite-splint was the clockwise rotation (opening) of the mandible and anterior translation of the condyle on the articular eminence, much as occurs normally during jaw depression. During the next 48 weeks, the mandible (1) rotated anti-clockwise (closed) due mainly to antero-superior displacement of the maxilla and intrusion of the mandibular dentition and (2) underwent a significant increase in length (p < 0.05). These findings indicate that the mandibular condyle of young adult monkeys is capable of small, but biologically significant, compensatory growth after displacement.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25810/1/0000373.pd

Case report of carbon monoxide poisoning in a pregnant patient: mother died, baby survived

Carbon monoxide poisoning in pregnant women is a relatively rare condition. We report a 32-year-old woman in her 32nd week of pregnancy found unconscious in the bathroom. On arrival, her pulse and blood pressure were undetectable. Cardiopulmonary resuscitation was applied. The mother's carboxyhaemoglobin level was 57%. Due to foetal distress, Caesarean section was performed in the emergency department. The baby was intubated due to the absence of spontaneous respiration. The level of carboxyhaemoglobin in the cord blood was 32%. After staying in the newborn unit for 47 days, the baby was discharged with a sequela of cerebral palsy. (Hong Kong j.emerg. med. 2009;16:176-178

Cardiovascular view of intermediate and high-risk COVID-19 patients: single-centre experience with low mortality and intensive care hospitalisation rates.

AIM: The purpose of this article was to report the low rates of intensive care unit admission and mortality in intermediateand high-risk COVID-19 patients, and to share our clinical approach with other colleagues. In addition, we sought to reveal the relationship between myocardial injury and clinical outcomes such as death, intensive care unit uptake and hospital stay, and the relationship between inflammatory parameters and cardiac biomarkers in a cardiovascular perspective. METHODS: Patients admitted to the emergency department in the Department of Internal Medicine, Faculty of Medicine, Istanbul University, with laboratory or clinically and radiologically confirmed COVID-19 were included in this retrospective cross-sectional study, which was conducted from 11 March to 10 April 2020. The demographic (age and gender) and clinical (symptoms, co-morbidities, treatments, complications and outcomes) characteristics, laboratory findings, and results of cardiac examinations (cardiac biomarkers and electrocardiography) of patients during hospitalisation were collected from their medical records by two investigators. Data were analysed using SPSS version 25.0 (IBM). A twosided p <0.05 was considered statistically significant. Analysis began on 11 April 2020. RESULTS: Mortality and intensive care unit admission rates were statistically significantly higher in patients with cardiac injury than in those without. There was a positive correlation between levels of high-sensitivity TNT and fibrinogen, D-dimer, ferritin, procalcitonin and C-reactive protein (r = 0.24, p <0.01; r = 0.37, p <0.01; r = 0.25, p <0.01, r = 0.34, p <0.01; r = 0.31, p <0.01). CONCLUSION: The first general data of our 309 patients regarding low mortality and intensive care admission rates, and particular treatment algorithms specific to our centre should be helpful in determining better treatment strategies in the future. Our study emphasises the importance and frequency of cardiovascular outcomes, and the significance of some cardiac biomarkers in predicting COVID-19 prognosis

A novel parameter for the diagnosis of acute pulmonary embolism: the T-wave peak-to-end interval

OBJECTIVE: Acute pulmonary embolism (APE) is a very common disease that must be diagnosed and treated quickly and accurately to reduce significant morbidity and mortality rates. Acute pulmonary embolism is associated with numerous electrocardiographic (ECG) changes including prolonged QT interval with global T-wave inversion. The aim of the study was to investigate the relationship between the T-wave peak-to-end interval and diagnosis of APE, which has never been investigated in the literature