2,620 research outputs found
Aspects of Cooling at the TRIP Facility
The TriP facility at KVI is dedicated to provide short lived radioactive
isotopes at low kinetic energies to users. It comprised different cooling
schemes for a variety of energy ranges, from GeV down to the neV scale. The
isotopes are produced using beam of the AGOR cyclotron at KVI. They are
separated from the primary beam by a magnetic separator. A crucial part of such
a facility is the ability to stop and extract isotopes into a low energy
beamline which guides them to the experiment. In particular we are
investigating stopping in matter and buffer gases. After the extraction the
isotopes can be stored in neutral atoms or ion traps for experiments. Our
research includes precision studies of nuclear -decay through
- momentum correlations as well as searches for permanent electric
dipole moments in heavy atomic systems like radium. Such experiments offer a
large potential for discovering new physics.Comment: COOL05 Workshop, Galena, Il, USA, 18-23. Sept. 2005, 5 pages, 3
figure
Big data in economics: evolution or revolution?
The Big Data Era creates a lot of exciting opportunities for new developments in economics and econometrics. At the same time, however, the analysis of large datasets poses difficult methodological problems that should be addressed
appropriately and are the subject of the present chapter
Challenges in economic evaluations in obstetric care : a scoping review and expert opinion
© 2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.Peer reviewedPublisher PD
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So you call that research? : mending methodological biases in strategy and organization departments of top business schools
We believe that all strategy and organization (SO) scholars should be able to decide for themselves whether to specialize in certain parts of the knowledge cycle or adopt a broader, multi-method view on the scientific process. In a situation of ―methodological pluralism‖, individuals might choose to contribute to the construction of new administrative theories by means of qualitative works like case studies, ethnographies, biographies, or grounded theory studies (e.g., see Denzin and Lincoln, 2000). Others could then specialize in testing these theories by means of experiments, surveys, or longitudinal econometric studies (e.g., see Lewis-Beck, 1987-2004). Again others could combine both approaches in Herculean attempts to conduct high-impact, integrative research with the potential to change the way we understand the field as a whole
Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis
AbstractCrystal structures of the DNA repair enzyme human uracil-DNA glycosylase (UDG), combined with mutational analysis, reveal the structural basis for the specificity of the enzyme. Within the classic α/β fold of UDG, sequence-conserved residues form a positively charged, active-site groove the width of duplex DNA, at the C-terminal edge of the central four-stranded parallel β sheet. In the UDG-6-aminouracil complex, uracil binds at the base of the groove within a rigid preformed pocket that confers selectivity for uracil over other bases by shape complementarity and by main chain and Asn-204 side chain hydrogen bonds. Main chain nitrogen atoms are positioned to stabilize the oxyanion intermediate generated by His-268 acting via nucleophilic attack or general base mechanisms. Specific binding of uracil flipped out from a DNA duplex provides a structural mechanism for damaged base recognition
Dislocation loops in overheated free-standing smectic films
Static and dynamic phenomena in overheated free-standing smectic-A films are
studied using a generalization of de Gennes' theory for a confined presmectic
liquid. A static application is to determine the profile of the film meniscus
and the meniscus contact angle, the results being compared with those of a
recent study employing de Gennes' original theory. The dynamical generalization
of the theory is based on on a time-dependent Ginzburg-Landau approach. This is
used to compare two modes for layer-thinning transitions in overheated films,
namely "uniform thinning" vs. nucleation of dislocation loops. Properties such
as the line tension and velocity of a moving dislocation line are evaluated
self-consistently by the theory.Comment: 16 pages, 8 figure
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