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Creep in fibre-reinforced polymer mat composites
Tensile creeps have been conducted upon a woven, glass-fibre laminated epoxy composite and a 0/90° cross ply, carbon fibre reinforced epoxy composite. For the laminate loading was aligned with a fibre direction. For the ply the loading was inclined to the fibres (off-axis).
Testing to stress levels up to 200 MPa and temperatures in the range 20°- 200°C has revealed a form of creep in each material. The creep observed is essentially primary in nature but with extended time •1000 h, it may exhaust or resemble a pseudo-secondary regime with a low rate. Where the load carrying capacity is lost, through fibre breakage or tab slip, the creep rate accelerates suddenly to infinity in a few hours. Smooth creep curves apply to successful tests but many irregular curves resulted from grip failure. A phenomenological approach was used to model smooth curves using a summation of instantaneous, primary and secondary strain terms. For the mat reinforcement a consistent trend was not found between the secondary creep rate and a stress that was raised incrementally upon the same testpiece. However the cumulative instantaneous strain provided the correct elastic modulus. Creep in the solid laminate was believed to be due to a fibre straightening that yielded a limiting strain in a time beyond which the process exhausts.
Creep in cfrc was only evident when the fibres were inclined to the stress axis, indicating a viscous flow in the matrix. Moreover, it is believed that a viscous shear sliding between laminates or plies is more likely to contribute to an off-axis deformation mode which is not strain limited.http://www.brunel.ac.uk/about/acad/sed/sedstaff/design/DavidRee
Herman Melville and the Problem of Evil
Part of a series of public lectures delivered at The Rice Institute on Sunday afternoons during autumn 194
Breaking the prejudice habit: Mechanisms, timecourse, and longevity
The prejudice habit-breaking intervention (Devine et al., 2012) and its offshoots (e.g., Carnes et al., 2012) have shown promise in effecting long-term change in key outcomes related to intergroup bias, including increases in awareness, concern about discrimination, and, in one study, long-term decreases in implicit bias. This intervention is based on the premise that unintentional bias is like a habit that can be broken with sufficient motivation, awareness, and effort. We conducted replication of the original habit-breaking intervention experiment in a sample more than three times the size of the original (N = 292). We also measured all outcomes every other day for 14 days and measured potential mechanisms for the intervention’s effects. Consistent with previous results, the habit-breaking intervention produced a change in concern that endured two weeks post-intervention. These effects were associated with increased sensitivity to the biases of others and an increased tendency to label biases as wrong. Contrasting with the original work, both control and intervention participants decreased in implicit bias, and the effects of the habit-breaking intervention on awareness declined in the second week of the study. In a subsample recruited two years later, intervention participants were more likely than control participants to object on a public online forum to an essay endorsing racial stereotyping. Our results suggest that the habit-breaking intervention produces enduring changes in peoples’ knowledge of and beliefs about race-related issues, and we argue that these changes are even more important for promoting long-term behavioral change than are changes in implicit bias
The potential of cell cultures for the production of salt tolerant cultivars.
The progress towards the production of salt tolerant plants through selection in cell cultures is
briefly reviewed. The need for a fuller understanding of the mechanisms of salt tolerance in
non-halophytes is emphasised and illustrated with reference to recent investigations on the role of
proline. A clear protective effect, against salt stress, of exogenously applied proline has been
demonstrated suggesting elevated levels of endogenous proline synthesis, for which there is a direct
selection procedure, as a basis for improved salt tolerance.
Salt tolerance of proline-overproducing plants and cell cultures is currently under investigation
in a Nicotiana sylvestris line with almost 100-fold increase in free proline
Use of systems biology to decipher host–pathogen interaction networks and predict biomarkers
AbstractIn systems biology, researchers aim to understand complex biological systems as a whole, which is often achieved by mathematical modelling and the analyses of high-throughput data. In this review, we give an overview of medical applications of systems biology approaches with special focus on host–pathogen interactions. After introducing general ideas of systems biology, we focus on (1) the detection of putative biomarkers for improved diagnosis and support of therapeutic decisions, (2) network modelling for the identification of regulatory interactions between cellular molecules to reveal putative drug targets and (3) module discovery for the detection of phenotype-specific modules in molecular interaction networks. Biomarker detection applies supervised machine learning methods utilizing high-throughput data (e.g. single nucleotide polymorphism (SNP) detection, RNA-seq, proteomics) and clinical data. We demonstrate structural analysis of molecular networks, especially by identification of disease modules as a novel strategy, and discuss possible applications to host–pathogen interactions. Pioneering work was done to predict molecular host–pathogen interactions networks based on dual RNA-seq data. However, currently this network modelling is restricted to a small number of genes. With increasing number and quality of databases and data repositories, the prediction of large-scale networks will also be feasible that can used for multidimensional diagnosis and decision support for prevention and therapy of diseases. Finally, we outline further perspective issues such as support of personalized medicine with high-throughput data and generation of multiscale host–pathogen interaction models
Effectiveness of the ADEC as a level 2 screening test for young children with suspected autism spectrum disorders in a clinical setting
Background The Autism Detection in Early Childhood (ADEC) is a clinician-administered, Level 2 screening tool. A retrospective file audit was used to investigate its clinical effectiveness.
Method Toddlers referred to an Australian child development service between 2008 and 2010 (N?=?53, M age?=?32.2 months) were screened with the ADEC. Their medical records were reviewed in 2013 when their mean age was 74.5 months, and the original ADEC screening results were compared with later diagnostic outcomes.
Results The ADEC had good sensitivity (87.5%) and moderate specificity (62%). Three behaviours predicted autism spectrum disorders (ASDs): response to name, gaze switching, and gaze monitoring (p???.001).
Conclusions The ADEC shows promise as a screening tool that can discriminate between young children with ASDs and those who have specific communication disorders or developmental delays that persist into middle childhood but who do not meet the criteria for ASDs
IHOC Summary For Members - Helping Your Child’s Doctor Helps Your Child
IHOC’s goal is to improve the health of children. For example, many children in Maine do not get their vaccines on time. So IHOC will work with doctor’s offices to help more children get their vaccines on time. This will help protect all children in the state, by reducing certain contagious illnesses
IHOC Summary For Providers - Improving Health Outcomes for Children in Maine and Vermont
In February 2010, Maine and Vermont were awarded a five-year child health quality improvement grant. The project focuses on using quality measures and information technology to improve health outcomes for children. The goal is to improve timely access to quality care for children who are insured by Medicaid
The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells
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