The GBT-SCA, a radiation tolerant ASIC for detector control applications in SLHC experiments

This work describes the architecture of the GigaBit Transceiver – Slow Control Adapter (GBT–SCA) ASIC suitable for the control and monitoring applications of the embedded front-end electronics in the future SLHC experiments. The GBT–SCA is part the GBT chipset currently under development for the SLHC detector upgrades. It is designed for radiation tolerance and it will be fabricated in a commercial 130 nm CMOS technology. The paper discusses the GBT-SCA architecture, the data transfer protocol, the ASIC interfaces, and its integration with the GBT optical link. The GBT–SCA is one the components of the GBT system chipset. It is proposed for the future SLHC experiments and is designed to be configurable matching different front-end system requirements. The GBT-SCA is intended for the slow control and monitoring of the embedded front end electronics and implements a point-to-multi point connection between one GBT optical link ASIC and several front end ASICs. The GBT-SCA connects to a dedicated electrical port on the GBT ASIC that provides 80 Mbps of bidirectional data traffic. If needed, more than one GBT-SCA ASIC can be connected to a GBT ASIC thus increasing the control and monitoring capabilities in the system. The GBT-SCA ASIC features several I/O ports to interface with the embedded front-end ASICs. There are 16 I2C buses, 1 JTAG controller port, 4 8- bit wide parallel-ports, a memory bus controller and an ADC to monitor up to 8 external analog signals. All these ports are accessible from the counting room electronics, via the GBT optical link system. Special design techniques are being employed to protect the operation of the GBT-SCA against radiation induced Single-Event-Upsets to a level that is compatible for the SLHC experiments. The paper will present the overall architecture of the GBTSCA ASIC describing in detail the design of the peripheral controllers for the individual I/O ports, the network controller that implements the connectivity with the GBT ASIC and will discuss the operation modes and the flow of information between the control electronics and the embedded front end ASICs

Status of the Cylindical-GEM project for the KLOE-2 Inner Tracker

The status of the R&D on the Cylindrical-GEM (CGEM) detector foreseen as Inner Tracker for KLOE-2, the upgrade of the KLOE experiment at the DAFNE phi-factory, will be presented. The R&D includes several activities: i) the construction and complete characterization of the full-size CGEM prototype, equipped with 650 microns pitch 1-D longitudinal strips; ii) the study of the 2-D readout with XV patterned strips and operation in magnetic field (up to 1.5T), performed with small planar prototypes in a dedicated test at the H4-SPS beam facility; iii) the characterization of the single-mask GEM technology for the realization of large-area GEM foils.Comment: 4 pages, 10 figures, Presented at Vienna Conference on Instrumentation (Feb 15-20, 2010, Vienna, Austria). Submitted to the Proceeding

Minkowski's Object: A Starburst Triggered by a Radio Jet, Revisited

We present neutral hydrogen, ultraviolet, optical and near-infrared imaging, and optical spectroscopy, of Minkowski's Object (MO), a star forming peculiar galaxy near NGC 541. The observations strengthen evidence that star formation in MO was triggered by the radio jet from NGC 541. Key new results are the discovery of a 4.9E8 solar mass double HI cloud straddling the radio jet downstream from MO, where the jet changes direction and decollimates; strong detections of MO, also showing double structure, in UV and H-alpha; and numerous HII regions and associated clusters in MO. In UV, MO resembles the radio-aligned, rest-frame UV morphologies in many high redshift radio galaxies (HzRGs), also thought to be caused by jet-induced star formation. MO's stellar population is dominated by a 7.5 Myr-old, 1.9E7 solar mass instantaneous burst, with current star formation rate 0.52 solar masses per year (concentrated upstream from where the HI column density is high). This is unlike the jet-induced star formation in Centaurus A, where the jet interacts with pre-existing cold gas; in MO the HI may have cooled out of a warmer, clumpy intergalactic or interstellar medium as a result of jet interaction, followed by collapse of the cooling clouds and subsequent star formation (consistent with numerical simulations). Since the radio source that triggered star formation in MO is much less luminous, and therefore more common, than powerful HzRGs, and because the environment around MO is not particularly special in terms of abundant dense, cold gas, jet-induced star formation in the early universe might be even more prevalent than previously thought.Comment: 52 pages, 15 figures, accepted for publication in Ap

Neutral Gas Distribution and Kinematics of the Nearly Face-on Spiral Galaxy NGC 1232

We have analyzed high velocity resolution HI synthesis observations of the nearly face-on Sc galaxy NGC 1232. The neutral gas distribution extends well beyond the optical extent of the galaxy. As expected, local peaks in the HI column density are associated with the spiral arms. Further, the HI column density drops precipitously near the center of the galaxy. Closed contours in the velocity field suggest either that the system is warped, or that the rotation curve declines. The velocity dispersion is approximately constant throughout the system, with a median value of 9.9 +/- 1.8 km/s. When corrected for rotational broadening, there is no indication of a radial trend in the neutral gas velocity dispersion in this galaxy.Comment: 14 pages of text, 10 pages of figures. Accepted to the A

XMM-Newton Surveys of the Canada-France Redshift Survey Fields - III: The Environments of X-ray Selected AGN at 0.4<z<0.6

The environmental properties of a sample of 31 hard X-ray selected AGN are investigated, from scales of 500 kpc down to 30 kpc, and are compared to a control sample of inactive galaxies. The AGN all lie in the redshift range 0.4<z<0.6. The accretion luminosity-density of the Universe peaks close to this redshift range, and the AGN in the sample have X-ray luminosities close to the knee in the hard X-ray luminosity function, making them representative of the population which dominated this important phase of energy conversion. Using both the spatial clustering amplitude and near neighbour counts it is found that the AGN have environments that are indistinguishable from normal, inactive galaxies over the same redshift range and with similar optical properties. Typically, the environments are of sub-cluster richness, in contrast to similar studies of high-z quasars, which are often found in clusters with comparable richness to the Abell R>=0 clusters. It is suggested that minor mergers with low mass companions is a likely candidate for the mechanism by which these modest luminosity AGN are fuelled.Comment: 12 pages, 6 figures, accepted by MNRA

Gene electrotransfer of IL-2 and IL-12 plasmids effectively eradicated murine B16.F10 melanoma

Gene therapy has become an important approach for treating cancer, and electroporation represents a technology for introducing therapeutic genes into a cell. An example of cancer gene therapy relying on gene electrotransfer is the use of immunomodulatory cytokines, such as interleukin 2 (IL-2) and 12 (IL-12), which directly stimulate immune cells at the tumour site. The aim of our study was to determine the effects of gene electrotransfer with two plasmids encoding IL-2 and IL-12 in vitro and in vivo. Two different pulse protocols, known as EP1 (600 V/cm, 5 ms, 1 Hz, 8 pulses) and EP2 (1300 V/cm, 100 µs, 1 Hz, 8 pulses), were assessed in vitro for application in subsequent in vivo experiments. In the in vivo experiment, gene electrotransfer of pIL-2 and pIL-12 using the EP1 protocol was performed in B16.F10 murine melanoma. Combined treatment of tumours using pIL2 and pIL12 induced significant tumour growth delay and 71% complete tumour regression. Furthermore, in tumours coexpressing IL-2 and IL-12, increased accumulation of dendritic cells and M1 macrophages was obtained along with the activation of proinflammatory signals, resulting in CD4 + and CD8 + T-lymphocyte recruitment and immune memory development in the mice. In conclusion, we demonstrated high antitumour efficacy of combined IL-2 and IL-12 gene electrotransfer protocols in low-immunogenicity murine B16.F10 melanoma