Endpoint behavior of high-energy scattering cross sections

In high-energy processes near the endpoint, there emerge new contributions associated with spectator interactions. Away from the endpoint region, these new contributions are suppressed compared to the leading contribution, but the leading contribution becomes suppressed as we approach the endpoint and the new contributions become comparable. We present how the new contributions scale as we reach the endpoint and show that they are comparable to the suppressed leading contributions in deep-inelastic scattering by employing a power counting analysis. The hadronic tensor in deep-inelastic scattering is shown to factorize including the spectator interactions, and it can be expressed in terms of the lightcone distribution amplitudes of initial hadrons. We also consider the contribution of the spectator contributions in Drell-Yan processes. Here the spectator interactions are suppressed compared to double parton annihilation according to the power counting.Comment: 21 pages, 5 figures, published versio

The Costs of Low Birth Weight

Birth weight has emerged as the leading indicator of infant health and welfare and the central focus of infant health policy. This is because low birth weight (LBW) infants experience severe health and developmental difficulties that can impose enormous costs on society. But would the prevention of LBW generate equally sizable cost savings and health improvements? Estimates of the return to LBW-prevention from cross-sectional associations may be biased by omitted variables that cannot be influenced by policy, such as genetic factors. To address this, we compare the hospital costs, health at birth, and infant mortality rates between heavier and lighter infants from all twin pairs born in the United States. We also examine the effect of maternal smoking during pregnancy the leading risk factor for LBW in the United States on health among singleton births after controlling for detailed background characteristics. Both analyses imply substantially smaller effects of LBW than previously thought, suggesting two possibilities: 1) existing estimates overstate the true costs and consequences of LBW by at least a factor of four and by as much as a factor of 20; or 2) different LBW-preventing interventions have different health and cost consequences, implying that policy efforts that presume a single return to reducing LBW will necessarily be suboptimal.

The central role of noise in evaluating interventions that use test scores to rank schools

Several countries have implemented programs that use test scores to rank schools, and to reward or penalize them based on their students' average performance. Recently, Kane and Staiger (2002) have warned that imprecision in the measurement of school-level test scores could impede these efforts. There is little evidence, however, on how seriously noise hinders the evaluation of the impact of these interventions. We examine these issues in the context of Chile's P-900 program-a country-wide intervention in which resources were allocated based on cutoffs in schools' mean test scores. We show that transitory noise in average scores and mean reversion lead conventional estimation approaches to greatly overstate the impacts of such programs. We then show how a regression discontinuity design that utilizes the discrete nature of the selection rule can be used to control for reversion biases. While the RD analysis provides convincing evidence that the P-900 program had significant effects on test score gains, these effects are much smaller than is widely believed

Soft-Collinear Messengers: A New Mode in Soft-Collinear Effective Theory

It is argued that soft-collinear effective theory for processes involving both soft and collinear partons, such as exclusive B-meson decays, should include a new mode in addition to soft and collinear fields. These "soft-collinear messengers" can interact with both soft and collinear particles without taking them far off-shell. They thus can communicate between the soft and collinear sectors of the theory. The relevance of the new mode is demonstrated with an explicit example, and the formalism incorporating the corresponding quark and gluon fields into the effective Lagrangian is developed.Comment: 22 pages, 5 figures. Extended Section 6, clarifying the relevance of different types of soft-collinear interaction

Correlation between antibacterial activity and yeast extract of Orthosiphon stamineus extract

This paper investigates the boosting antibacterial effect of O. stamineus extracts supplemented with 1.0, 2.0, 3.0, 4.0 and 5.0 mg/ml concentration of yeast extracts. Leaves and stems of O. stamineus were extracted with methanol to assess their different antibacterial potential against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa through disc diffusion assay. Post-hoc comparisons using Tukey HSD test indicated the mean zone of inhibition for leaves extract (M = 8.67, SD = 0.58) was different compared to stems extract (M = 10.33, SD = 0.58) towards S. aureus. Zone of inhibition produced by the leaves extract (M = 6.67, SD = 0.58) was different compared to the stems extract (M = 7.00, SD = 0.00) towards E. coli. O. stamineus have no antibacterial potential against P. aeruginosa. This study showed the addition of yeast extract have no enhancing or reducing effect towards antibacterial potential. The Pearson correlation coefficient ranging from r(6) = -0.003 to -0.594, p < 0.212 to 0.996.Keywords: correlation; antibacterial activity; yeast extract; Orthosiphon staminue

Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment

Taste assessment in an increasingly important aspect of formulation development, particularly for paediatric medications. Electronic taste sensing systems have the potential to offer a rapid, objective and safe method of taste assessment prior to the use of more costly human panels or animal models. In this study, the ability of the TS-5000Z taste sensing system to assess the taste masking efficiency of (2-hydroxypropyl)-β-cyclodextrin (HP-β-CyD) complexes with ranitidine hydrochloride was evaluated in order to explore the potential of the biosensor approach as a means of assessing taste masking by inclusion complexation. Nuclear magnetic resonance (NMR) spectroscopy and molecular docking studies were employed to identify and examine the interaction between ranitidine hydrochloride and HP-β-CyD. Taste-masking efficiencies were determined by the Euclidean distance between taste-masked formulations and the pure drug substance on a PCA score plot. The results showed that with increasing molarity of HP-β-CyD in the formulation, the distance from ranitidine hydrochloride increased, thus indicating a significant difference between the taste of the formulation and that of the pure drug. NMR studies also provided strong supporting evidence for the complexation between HP-β-CyD and ranitidine hydrochloride, with the H3′ region of the former identified as the most likely binding site for the drug. Molecular docking studies suggested that the dimethylamino and diamine groups of the drug form direct hydrogen bonds with the hydroxyl oxygen atoms of HP-β-CyD, while the furan ring docks in close proximity to H3′. This study has demonstrated that the biosensor system may provide quantitative data to assess bitterness of inclusion complexes with HP-β-CyD, while spectroscopic and modelling studies may provide a mechanistic explanation for the taste masking process. This in turn suggests that there is a role for biosensor approaches in providing early screening for taste masking using inclusion complexation and that the combination with mechanistic studies may provide insights into the molecular basis of taste and taste masking

Phenylbutazone in the horse: a review

Phenylbutazone is an acidic, lipophilic, nonsteroidal anti-inflammatory drug (NSAID). It is extensively metabolized in the horse. The metabolites so far identified, oxyphenbutazone, y-hydroxyphenylbutazone and y-hydroxyoxyphenbutazone. account for some 25-30% of administered dose over 24 h. The plasma half-life of phenylbutazone and termination of its pharmacological action are determined primarily by its rate of hepatic metabolism. Phenylbutazone acts by inhibiting the cyclooxygenase enzyme system, which is responsible for synthesis of prostanoids such as PGE?. It appears to act on prostaglalidin-H synthase and prostacyclin synthase, after conversion by prostaglandin-H synthase to reactive intermediates. It markedly reduces prostanoid-dependent swelling, edema, erythema, and hypersensitivity to pain in inflamed tissues. Its principal use in the horse is for treatment of soft tissue inflammation. Phenylbutazone is highly bound (\u3e 98%) to plasma protein. After i.v. injection, blood levels decline with an elimination half-life of 3-10 h. The plasma kinetics of phenylbutazone may be dose dependent, with the plasma half-life increasing as the drug dosage level increases. Plasma residues of the drug at 24 h after a single i.v. dose of 2 g/450 kg average about 0.9 pg/ml, but considerable variation occurs. If dosing is repeated, the plasma residue accumulates to give mean residual blood levels of approxiniately 4.5 pg/ml on Day 5 after 4 days of dosing. Approximately similar blood levels are found after a combination of oral and i.v. dosing. Experiments on large numbers of horses in training have been undertaken to ascertain the population distributions of residual blood levels after such dosing schedules. Absorption of phenylbutazone from the gastrointestinal tract is influenced by the dose administered and the relationship of dosing to feeding. Access to hay can delay the time of peak plasma concentration to 18 h or longer. Under optimal conditions, the bioavailability of oral phenylbutazone is probably in the region of 70%. Paste preparations may be more slowly absorbed than other preparations and yield higher residual plasma levels at 24 h after dosing, but further controlled studies are required. Phenylbutazone is easily detected in the plasma and urine of horses but concentrations in saliva are low. It is quantitated for forensic purposes by HPLC. The variability of this method between laboratories is about k 25%. Increasing urinary pH increases the urinary concentration of phenylbutazone and its metabolites up to 200-fold. However, urinary pH has little effect on the plasma half-life of phenylbutazone, which is determined mainly by hepatic metabolism and possibly by biliary secretion. Phenylbutazone has a narrow therapeutic index in the horse. If the administered dose is greater than recommended by the manufacturer, toxic effects may be produced, especially if high dose administration is maintained for more than a few days. Signs of toxicity include anorexia, depression, oral and GI ulcers, plasma protein losing enteropathy, and death from shock. Other side-effects include toxic neutropenia, hepatotoxicity and renal papillary necrosis; the latter may occur if access to water is restricted. If phenylbutazone is withdrawn in the early stages of toxicity, the prognosis is good. Late withdrawal is associated with delayed recovery. Death may occur up to 50 days after withdrawal of the drug. This toxicity can be antagonized by administration of prostaglandins

Inclusive Semileptonic Decays in QCD Including Lepton Mass Effects

Starting from an Operator Product Expansion in the Heavy Quark Effective Theory up to order 1/m_b^2 we calculate the inclusive semileptonic decays of unpolarized bottom hadrons including lepton mass effects. We calculate the differential decay spectra d\Gamma/(dE_\tau ), and the total decay rate for B meson decays to final states containing a \tau lepton.Comment: 16 pages + 4 figs. appended in uuencoded form, LaTeX, MZ-TH/93-3

Tau Polarization in Λb→Xcτνˉ \Lambda_b \to X_c \tau \bar{\nu} and B→XcτνˉB \to X_c \tau \bar{\nu}

We discuss the longitudinal and transverse $\tau$-polarization in inclusive decays of hadrons containing $b$-quarks. The calculation is performed by means of an OPE in HQET. Some mathematical difficulties in calculating transverse polarizations are explained. Numerical results are presented for longitudinal and for transverse polarizations, both in and perpendicular to the decay plane.Comment: LATEX, 20 pages, 5 Postscript figure

Model Independent Extraction of ∣Vbc∣|V_{\rm bc}| Without Heavy Quark Symmetry

A new method to extract $|V_{\rm bc}|$ is proposed based on a sum--rule for semileptonic decays of the $B$ meson. The method relies on much weaker assumptions than previous approaches which are based on heavy--quark symmetry. This sum--rule only relies on the assumption that the virtual $c \overline{c}$ pair content of the $B$ meson can be neglected. The extraction of the CKM matrix element also requires that the sum--rule saturates in the kinematically accessible region.Comment: 10 pages revtex3 manuscript. No figures, U. of MD PP #94--086. With our apologies, some innocuous errors corrected and some references added that had been brought to our attentio