39 research outputs found

    Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

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    Purpose Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes

    Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

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    Purpose: Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods: Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results: The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion: We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes

    Space-Time Functional Gradient Optimization for Motion Planning

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    Abstract — Functional gradient algorithms (e.g. CHOMP) have recently shown great promise for producing locally optimal motion for complex many degree-of-freedom robots. A key limitation of such algorithms is the difficulty in incorporating constraints and cost functions that explicitly depend on time. We present T-CHOMP, a functional gradient algorithm that overcomes this limitation by directly optimizing in space-time. We outline a framework for joint space-time optimization, derive an efficient trajectory-wide update for maintaining time monotonicity, and demonstrate the significance of T-CHOMP over CHOMP in several scenarios. By manipulating time, T-CHOMP produces lower-cost trajectories leading to behavior that is meaningfully different from CHOMP. I

    Murine oligodendroglial cells express nerve growth factor.

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    Politics of climate change in India : narratives of equity and cobenefits

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    India occupies an intriguing dual position in global climate politics—a poor and developing economy with low levels of historical and per capita emissions, and a large and rapidly growing economy with rising emissions. Indian climate politics has substantially been shaped around the first perspective, and increasingly, under international pressure, is being forced to grapple with the second. This review of Indian climate politics examines the initial crystallization of Indian climate positions and its roots in national climate politics, and then examines the modest ways in which climate politics have been revisited in domestic debates since about 2007. Following elucidation of these themes, the article turns to a discussion of new directions for Indian climate policy and their moorings in domestic climate politics
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