Biphasic alveolosquamoid renal carcinoma: A histomorphological, immunohistochemical, molecular genetic, and ultrastructural study of a distinctive morphologic variant of renal cell carcinoma

10.1016/j.anndiagpath.2012.08.007Annals of Diagnostic Pathology166459-469ANDP

Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma

10.1016/j.humpath.2012.11.019Human Pathology4471412-1420HPCQ

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. the tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. the epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. in all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.Charles Univ Prague, Lab Spec Diagnost Med Fac Hosp, Sikls Dept Pathol, Plzen 30460, Czech RepublicCharles Univ Prague, Fac Hosp, Dept Pathol, Plzen 30460, Czech RepublicCharles Univ Prague, Fac Hosp, Dept Urol, Plzen 30460, Czech RepublicRed Cross Hosp Kochi, Kochi, JapanKansai Med Univ, Hirakata Hosp, Dept Pathol, Osaka, JapanUniv Zagreb, Univ Hosp Dubrava, Zagreb, CroatiaEPM UNIFESP, São Paulo, BrazilCytopathos SRO, Bratislava, SlovakiaEPM UNIFESP, São Paulo, BrazilIGA 9722-4Web of Scienc

The leiomyomatous stroma in renal cell carcinomas is polyclonal and not part of the neoplastic process

10.1007/s00428-014-1591-9Virchows ArchivVARC