Fitting Jump Models

We describe a new framework for fitting jump models to a sequence of data. The key idea is to alternate between minimizing a loss function to fit multiple model parameters, and minimizing a discrete loss function to determine which set of model parameters is active at each data point. The framework is quite general and encompasses popular classes of models, such as hidden Markov models and piecewise affine models. The shape of the chosen loss functions to minimize determine the shape of the resulting jump model.Comment: Accepted for publication in Automatic

Shaping the formation of university-industry research collaborations: what type of proximity does really matter?

Research collaborations between universities and industry (U-I) are considered to be one important channel of potential localized knowledge spillovers (LKS). These collaborations favour both intended and unintended flows of knowledge and facilitate learning processes between partners from different organizations. Despite the copious literature on LKS, still little is known about the factors driving the formation of U-I research collaborations and, in particular, about the role that geographical proximity plays in the establishment of such relationships. Using collaborative research grants between universities and business firms awarded by the UK Engineering and Physical Sciences Research Council (EPSRC), in this article we disentangle some of the conditions under which different kinds of proximity contribute to the formation of U-I research collaborations, focusing in particular on clustering and technological complementarity among the firms participating in such partnerships

Tuning of subspace predictive controls

Data-driven predictive control has recently gained increasing attention, as it makes it possible to design constrained controls directly from a set of data, without requiring an intermediate identification step. In this paper, we focus on a Subspace Predictive Control (SPC) scheme, with the aim of clarifying the sensitivity of the final closed-loop performance to its main hyperparameters, namely the length of the past horizon and the regularization penalties. Moreover, by delving deep into the structural properties of the control problem formulation, we provide a set of guidelines for the choice of such hyperparameters. The effectiveness of the resulting overall tuning strategy is assessed on two benchmark examples.</p

Maternal mortality in 19th- and early 20th-century Italy

Although dramatically reduced in Western and developed countries, maternal mortality is still today one of the most relevant social and health scourges in developing countries. This is the reason why high levels of maternal mortality are always interpreted as a sign of low living standards, ignorance, poverty and woman discrimination. Maternal mortality represents, therefore, a very peculiar characteristic of demographic systems of ancien regime. Despite this important role in demographic systems, no systematic study has been addressed to investigate the impact of maternal mortality in historical Italy. The aim of this article is to shed some light on such a phenomenon by investigating its trend over time and the determinants in some Italian populations between the 18th and the early 20th centuries. The analysis will make use of civil and parish registers linked together by means of nominative techniques, and it will be, therefore, carried out at the micro level

Zirconia-reinforced lithium silicate (ZLS) mechanical and biological properties: A literature review

Objectives: This paper aimed to provide a literature review of the mechanical and biological properties of zirconia-reinforced lithium silicate glass-ceramics (ZLS) in Computer-aided design / Computer-aided manufacturing (CAD/CAM) systems. Data/Sources: An extensive search of the literature for papers related to ZLS was made on the databases of PubMed/Medline, Scopus, Embase, Google Scholar, Dynamed, and Open Grey. The papers were selected by 3 independent calibrated reviewers. Study selection: The search strategy produced 937 records. After the removal of duplicates and the exclusion of papers that did not meet the inclusion criteria, 71 papers were included. Conclusions: After reviewing the included records, it was found that two types of ZLS (Vita Suprinity PC; Vita Zahnfabrik and Celtra Duo; Dentsply Sirona) are nowadays available on the market for CAD/CAM systems, similar in their chemical composition, microstructure, and biological-mechanical properties. ZLS is reported to be a biocompatible material, whose fracture resistance can withstand physiological chewing loads. The firing process influences the improvements of strength and fatigue failure load, with a volumetric shrinkage. To date, ZLS can be considered a viable alternative to other glass-ceramics for fixed single restorations. Clinical Significance:. As to biocompatibility and mechanical properties of ZLS, data are still scarce, often controversial and limited to short-term observational periods. These promising ceramics require further in vitro/in vivo studies to accurately define mechanical and biological properties, mainly in the long-term performance of restorations produced with such materials

The occlusal precision of milled versus printed provisional crowns

Objectives: The aim of this study was to compare the occlusal precision of computer-aided-design/ computer-assisted-manufacturing (CAD/CAM) milled versus 3D printed polymethylmethacrylate (PMMA) temporary prosthetic crowns, starting from the same digital CAD design. Materials and methods: The study sample included 34 patients presenting 34 premolars in need of prosthetic rehabilitation: a total of 68 temporary crowns were manufactured, 34 of which milled and 34 printed. Immediately after manufacturing, the milled and printed provisionals were scanned with a desktop scanner (E1, 3Shape) to obtain STL files, that were superimposed to the original CAD design in order to identify the occlusal trueness (Analysis A). A second occlusal comparison was performed by scanning both kind of provisional after being placed intraorally with Trios scanner (3 Shape); intraoral scans were obtained in order to compare STL files of provisionals before and after occlusal adjustments (Analysis B). The occlusal trueness was identified at three reference points, P1 (vestibular cusp), P2 (palatal / lingual cusp), P3 (central fossa). The statistical analysis was performed using the R 3.4.3 statistical software (The R Foundation for Statistical Computing), with a significance level of p &lt;0.05. Results: Overall, the printed crowns showed lower occlusal differences than the milled crowns, when compared to the CAD design file, with a statistically significant difference in P1 (difference of 0.025 ± 0.046 mm), P2 (difference of 0.027 ± 0 0.044 mm) and P3 ( difference of 0.018 ± 0.050) for Analysis A (p &lt;0.05). In the Analysis B the direct comparison between the degree of average difference between the pre-adjustment and the post-occlusal adjustment of the milled and printed crowns shows that the printed crowns have lower occlusal mean difference values in all three points compared to the milled ones (difference of 0.146 ± 0.273 mm in P1, 0.285 ± 0.360 mm in P2 and 0.257 ± 0.277 mm in P3). Conclusions: Within the limitation of this study, the data obtained showed a better occlusal surface dimensional accuracy of the 3D printed provisional crowns, when compared to the milled ones. Comparing the results obtained, it is possible to assume that the intraoral scans also had a contribution to occlusion, beside the manufacturing method. 3D printing can be successfully applied for manufacturing temporary PMMA crowns

Collagen degradation by host-derived enzymes during aging

Incompletely infiltrated collagen fibrils in acid-etched dentin are susceptible to degradation. We hypothesize that degradation can occur in the absence of bacteria. Partially demineralized collagen matrices (DCMs) prepared from human dentin were stored in artificial saliva. Control specimens were stored in artificial saliva containing proteolytic enzyme inhibitors, or pure mineral oil. We retrieved them at 24 hrs, 90 and 250 days to examine the extent of degradation of DCM. In the 24-hour experimental and 90- and 250-day control specimens, we observed 5- to 6-μm-thick layers of DCM containing banded collagen fibrils. DCMs were almost completely destroyed in the 250-day experimental specimens, but not when incubated with enzyme inhibitors or mineral oil. Functional enzyme analysis of dentin powder revealed low levels of collagenolytic activity that was inhibited by protease inhibitors or 0.2% chlorhexidine. We hypothesize that collagen degradation occurred over time, via host-derived matrix metalloproteinases that are released slowly over time.published_or_final_versio