313 research outputs found
Absorbed radiation dosimetry of the D3-specific PET radioligand [18F]FluorTriopride estimated using rodent and nonhuman primate
[(18)F]FluorTriopride ([(18)F]FTP) is a dopamine D(3)-receptor preferring radioligand with potential for investigation of neuropsychiatric disorders including Parkinson disease, dystonia and schizophrenia. Here we estimate human radiation dosimetry for [(18)F]FTP based on the ex-vivo biodistribution in rodents and in vivo distribution in nonhuman primates. Biodistribution data were generated using male and female Sprague-Dawley rats injected with ~370 KBq of [(18)F]FTP and euthanized at 5, 30, 60, 120, and 240 min. Organs of interest were dissected, weighed and assayed for radioactivity content. PET imaging studies were performed in two male and one female macaque fascicularis administered 143-190 MBq of [(18)F]FTP and scanned whole-body in sequential sections. Organ residence times were calculated based on organ time activity curves (TAC) created from regions of Interest. OLINDA/EXM 1.1 was used to estimate human radiation dosimetry based on scaled organ residence times. In the rodent, the highest absorbed radiation dose was the upper large intestines (0.32-0.49 mGy/MBq), with an effective dose of 0.07 mSv/MBq in males and 0.1 mSv/MBq in females. For the nonhuman primate, however, the gallbladder wall was the critical organ (1.81 mGy/MBq), and the effective dose was 0.02 mSv/MBq. The species discrepancy in dosimetry estimates for [(18)F]FTP based on rat and primate data can be attributed to the slower transit of tracer through the hepatobiliary track of the primate compared to the rat, which lacks a gallbladder. Out findings demonstrate that the nonhuman primate model is more appropriate model for estimating human absorbed radiation dosimetry when hepatobiliary excretion plays a major role in radiotracer elimination
Respiratory diseases in the »Đuro Đakovic« smelting plant in Slavonski Brod
Uvodno su prikazani uvjeti rada (mikroklima i zaprašenost) u ljevaonici, a zatim su priopćeni rezultati ciljanoga zdravstvenog pregleda 190 radnika izvršenog u 1984. i 1985. godini. Pregled je bio usmjeren na bolesti i oštećenja respiratornog trakta. Najčešće su bile bolesti gornjih dišnih putova (19,4 %) a 12,6 % radnika imalo je kronični bronhitis. Jedan radnik s 25 godina radnog staža u ljevaonici na poslovima čišćenja odljevaka imao je silikozu, u jednog su rendgenološke promjene upućivale na početnu pneumokoniozu, dok je u dvojice nalaz bio suspektan na silikozu. Unatoč bitnom poboljšanju radnih uvjeta i smanjenju zaprašenosti nužni su redoviti pregledi radnika izloženih mineralnoj prašini.Ambient and other working conditions in the smelting plant are described. The results are presented of medical check-up of 190 workers performed in 1984 and 1985 with special emphasis on respiratory diseases. As many as 19.4 % of the examined workers showed affection of the upper respiratory tract, and 12.6 % suffered from chronic bronchitis. One worker with 25 years of work on cast cleaning had apparent silicosis, another showed X-rays findings indicative of silicosis and two workers were found suspect of having the disease. Despite a considerable improvement in working conditions regular medical check-ups of workers exposed to mineral dusts are mandatory
Space of State Vectors in PT Symmetrical Quantum Mechanics
Space of states of PT symmetrical quantum mechanics is examined. Requirement
that eigenstates with different eigenvalues must be orthogonal leads to the
conclusion that eigenfunctions belong to the space with an indefinite metric.
The self consistent expressions for the probability amplitude and average value
of operator are suggested. Further specification of space of state vectors
yield the superselection rule, redefining notion of the superposition
principle. The expression for the probability current density, satisfying
equation of continuity and vanishing for the bound state, is proposed.Comment: Revised version, explicit expressions for average values and
probability amplitude adde
Resummation of mass terms in perturbative massless quantum field theory
The neutral massless scalar quantum field in four-dimensional
space-time is considered, which is subject to a simple bilinear
self-interaction. Is is well-known from renormalization theory that adding a
term of the form to the Lagrangean has the formal
effect of shifting the particle mass from the original zero value to m after
resummation of all two-leg insertions in the Feynman graphs appearing in the
perturbative expansion of the S-matrix. However, this resummation is
accompanied by some subtleties if done in a proper mathematical manner.
Although the model seems to be almost trivial, is shows many interesting
features which are useful for the understanding of the convergence behavior of
perturbation theory in general. Some important facts in connection with the
basic principles of quantum field theory and distribution theory are
highlighted, and a remark is made on possible generalizations of the
distribution spaces used in local quantum field theory. A short discussion how
one can view the spontaneous breakdown of gauge symmetry in massive gauge
theories within a massless framework is presented.Comment: 15 pages, LaTeX (style files included), one section adde
Scattering theory for Klein-Gordon equations with non-positive energy
We study the scattering theory for charged Klein-Gordon equations:
\{{array}{l} (\p_{t}- \i v(x))^{2}\phi(t,x) \epsilon^{2}(x,
D_{x})\phi(t,x)=0,[2mm] \phi(0, x)= f_{0}, [2mm] \i^{-1} \p_{t}\phi(0, x)=
f_{1}, {array}. where: \epsilon^{2}(x, D_{x})= \sum_{1\leq j, k\leq
n}(\p_{x_{j}} \i b_{j}(x))A^{jk}(x)(\p_{x_{k}} \i b_{k}(x))+ m^{2}(x),
describing a Klein-Gordon field minimally coupled to an external
electromagnetic field described by the electric potential and magnetic
potential . The flow of the Klein-Gordon equation preserves the
energy: h[f, f]:= \int_{\rr^{n}}\bar{f}_{1}(x) f_{1}(x)+
\bar{f}_{0}(x)\epsilon^{2}(x, D_{x})f_{0}(x) - \bar{f}_{0}(x) v^{2}(x) f_{0}(x)
\d x. We consider the situation when the energy is not positive. In this
case the flow cannot be written as a unitary group on a Hilbert space, and the
Klein-Gordon equation may have complex eigenfrequencies. Using the theory of
definitizable operators on Krein spaces and time-dependent methods, we prove
the existence and completeness of wave operators, both in the short- and
long-range cases. The range of the wave operators are characterized in terms of
the spectral theory of the generator, as in the usual Hilbert space case
Robustness of circadian clocks to daylight fluctuations: hints from the picoeucaryote Ostreococcus tauri
The development of systemic approaches in biology has put emphasis on
identifying genetic modules whose behavior can be modeled accurately so as to
gain insight into their structure and function. However most gene circuits in a
cell are under control of external signals and thus quantitative agreement
between experimental data and a mathematical model is difficult. Circadian
biology has been one notable exception: quantitative models of the internal
clock that orchestrates biological processes over the 24-hour diurnal cycle
have been constructed for a few organisms, from cyanobacteria to plants and
mammals. In most cases, a complex architecture with interlocked feedback loops
has been evidenced. Here we present first modeling results for the circadian
clock of the green unicellular alga Ostreococcus tauri. Two plant-like clock
genes have been shown to play a central role in Ostreococcus clock. We find
that their expression time profiles can be accurately reproduced by a minimal
model of a two-gene transcriptional feedback loop. Remarkably, best adjustment
of data recorded under light/dark alternation is obtained when assuming that
the oscillator is not coupled to the diurnal cycle. This suggests that coupling
to light is confined to specific time intervals and has no dynamical effect
when the oscillator is entrained by the diurnal cycle. This intringuing
property may reflect a strategy to minimize the impact of fluctuations in
daylight intensity on the core circadian oscillator, a type of perturbation
that has been rarely considered when assessing the robustness of circadian
clocks
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