Sustainable Use of Recycled Asphalt Pavement in Soil Stabilization

This study addresses unused recycled asphalt pavement (RAP) incorporated into sedimentary soil from the Guabirotuba Formation in Curitiba, Southern Brazil. Different percentages of RAP, ranging from 0% to 80% by weight, were mixed with the pure soil, with and without the addition of pozzolanic Portland cement. Tests were conducted to evaluate the mixtures' compaction properties, mechanical strength, and expansion after curing for up to 28 days. The results showed that adding RAP improved the mixtures' unconfined compressive strength (qu) and splitting tensile strength (qt). Up to 60% RAP, the qu increased by 260 kPa, and the qt increased by 340 kPa compared to the pure soil. The California Bearing Ratio (CBR) tests demonstrated an 18.62% improvement when 80% RAP was added to the untreated soil. In addition, the RAP also reduced the expansion of the compacted blends, with values decreasing from 1.19% to 0.88% with 80% RAP replacement. The expansion value was further reduced to 0.86% when the cement was added. The cement-soil-RAP compacted blends showed suitability for subgrade reinforcement, meeting the criteria of expansion 2%. Additionally, 3% cement and 40% RAP mixtures were suitable as a sub-base layer, with expansion 20%. The results provide valuable insights into utilizing RAP as an alternative material in soil improvement techniques employing the novelty porosity-to-cement index. Doi: 10.28991/CEJ-2023-09-09-016 Full Text: PD

CD38 and anti-CD38 monoclonal antibodies in AL amyloidosis: Targeting plasma cells and beyond

Immunoglobulin light chain amyloidosis (AL amyloidosis) is a rare systemic disease characterized by monoclonal light chains (LCs) depositing in tissue as insoluble fibrils, causing irreversible tissue damage. The mechanisms involved in aggregation and deposition of LCs are not fully understood, but CD138/38 plasma cells (PCs) are undoubtedly involved in monoclonal LC production.CD38 is a pleiotropic molecule detectable on the surface of PCs and maintained during the neoplastic transformation in multiple myeloma (MM). CD38 is expressed on T, B and NK cell populations as well, though at a lower cell surface density. CD38 is an ideal target in the management of PC dyscrasia, including AL amyloidosis, and indeed anti-CD38 monoclonal antibodies (MoAbs) have promising therapeutic potential. Anti-CD38 MoAbs act both as PC-depleting agents and as modulators of the balance of the immune cells. These aspects, together with their interaction with Fc receptors (FcRs) and neonatal FcRs, are specifically addressed in this paper. Moreover, the initiallyavailable experiences with the anti-CD38 MoAb DARA in AL amyloidosis are reviewed

trans-Dichloridobis(2-methyl­aniline-κN)palladium(II)

In the title compound, [PdCl2(C7H9N)2], the Pd atom is situated on an inversion centre and displays a distorted square-planar coordination environment. The crystal structure displays weak inter­molecular N—H⋯Cl hydrogen bonding

Design and Simulation of a Model Predictive Controller (MPC) for a Seismic Uniaxial Shake Table

Shake table is one of the apparatus that aids in researches to generate techniques, structural developments, and strategies to prevent, prepare, and minimize an earthquake’s devastating effects. One important factor that should be considered in a shake table is the system dynamics due to control-structural interactions, which could either be linear or non-linear. To accurately model both has always been the challenge but becomes more plausible with the availability of faster hardware and computers and the continuous decrease in latency. Model Predictive Controller (MPC) is a type of controller extensively used in the industry that can be used on linear and non-linear systems. This study presents the design and simulation of an MPC for a uniaxial shake table intending to analyze the system’s behavior and accuracy. MATLAB Simulink was utilized to handle the simulation analysis of the controller. Different MPC parameters such as sample time, prediction horizon, control horizon, and closed-loop performance were manipulated and adjusted to observe their effects on the output of the system. A signal that mimics the actual earthquake data was inputted into the controller, and the system's behavior and outputs were measured and presented through graphical representations. To determine the accuracy of the system’s output, its relationship with the reference signal was compared. From the simulation produced, the system demonstrated high accuracy levels and could be adjusted depending on the set performance aggressiveness of the system

Il cesarino ovvero dell'arte di caualcare : dialogo

Port. orladaERM

Improving diagnosis for rare diseases: the experience of the Italian undiagnosed Rare diseases network

Background For a number of persons with rare diseases (RDs) a definite diagnosis remains undiscovered with relevant physical, psychological and social consequences. Undiagnosed RDs (URDs) require other than specialised clinical centres, outstanding molecular investigations, common protocols and dedicated actions at national and international levels; thus, many "Undiagnosed RDs programs" have been gradually developed on the grounds of a well-structured multidisciplinary approach. Methods The Italian Undiagnosed Rare Diseases Network (IURDN) was established in 2016 to improve the level of diagnosis of persons with URD living in Italy. Six Italian Centres of Expertise represented the network. The National Centre for Rare Diseases at the Istituto Superiore di Sanita coordinates the whole project. The software PhenoTips was used to collect the information of the clinical cases. Results One hundred and ten cases were analysed between March 2016 and June 2019. The age of onset of the diseases ranged from prenatal age to 51 years. Conditions were predominantly sporadic; almost all patients had multiple organs involvements. A total of 13/71 family cases were characterized by WES; in some families more than one individual was affected, so leading to 20/71 individuals investigated. Disease causing variants were identified in two cases and were associated to previously undescribed phenotypes. In 5 cases, new candidate genes were identified, although confirmatory tests are pending. In three families, investigations were not completed due to the scarce compliance of members and molecular investigations were temporary suspended. Finally, three cases (one familial) remain still unsolved. Twelve undiagnosed clinical cases were then selected to be shared at International level through PhenomeCentral in accordance to the UDNI statement. Conclusions Our results showed a molecular diagnostic yield of 53,8%; this value is comparable to the diagnostic rates reported in other international studies. Cases collected were also pooled with those collected by UDNI International Network. This represents a unique example of global initiative aimed at sharing and validating knowledge and experience in this field. IURDN is a multidisciplinary and useful initiative linking National and International efforts aimed at making timely and appropriate diagnoses in RD patients who still do not have a confirmed diagnosis even after a long time

Synthesis of air‐stable, odorless thiophenol surrogates via Ni‐Catalyzed C−S cross‐coupling

Thiophenols are versatile synthetic intermediates whose practical appeal is marred by their air sensitivity, toxicity and extreme malodor. Herein we report an efficient catalytic method for the preparation of S-aryl isothiouronium salts, and demonstrate that these air-stable, odorless solids serve as user-friendly sources of thiophenols in synthesis. Diverse isothiouronium salts featuring synthetically useful functionality are readily accessible via nickelcatalyzed C-S cross-coupling of (hetero)aryl iodides and thiourea. Convenient, chromatography-free isolation of these salts is achieved via precipitation, allowing the methodology to be translated directly to large scales. Thiophenols are liberated from the corresponding isothiouronium salts upon treatment with a weak base, enabling an in situ release / S-functionalization strategy that entirely negates the need to isolate, purify or manipulate these noxious reagent

ATLANTIC ‐ PRIMATES : a dataset of communities and occurrences of primates in the Atlantic Forests of South America

Primates play an important role in ecosystem functioning and offer critical insights into human evolution, biology, behavior, and emerging infectious diseases. There are 26 primate species in the Atlantic Forests of South America, 19 of them endemic. We compiled a dataset of 5,472 georeferenced locations of 26 native and 1 introduced primate species, as hybrids in the genera Callithrix and Alouatta. The dataset includes 700 primate communities, 8,121 single species occurrences and 714 estimates of primate population sizes, covering most natural forest types of the tropical and subtropical Atlantic Forest of Brazil, Paraguay and Argentina and some other biomes. On average, primate communities of the Atlantic Forest harbor 2 ± 1 species (range = 1–6). However, about 40% of primate communities contain only one species. Alouatta guariba (N = 2,188 records) and Sapajus nigritus (N = 1,127) were the species with the most records. Callicebus barbarabrownae (N = 35), Leontopithecus caissara (N = 38), and Sapajus libidinosus (N = 41) were the species with the least records. Recorded primate densities varied from 0.004 individuals/km2 (Alouatta guariba at Fragmento do Bugre, Paraná, Brazil) to 400 individuals/km2 (Alouatta caraya in Santiago, Rio Grande do Sul, Brazil). Our dataset reflects disparity between the numerous primate census conducted in the Atlantic Forest, in contrast to the scarcity of estimates of population sizes and densities. With these data, researchers can develop different macroecological and regional level studies, focusing on communities, populations, species co‐occurrence and distribution patterns. Moreover, the data can also be used to assess the consequences of fragmentation, defaunation, and disease outbreaks on different ecological processes, such as trophic cascades, species invasion or extinction, and community dynamics. There are no copyright restrictions. Please cite this Data Paper when the data are used in publications. We also request that researchers and teachers inform us of how they are using the data.Fil: Culot, Laurence. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Pereira, Lucas Augusto. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Agostini, Ilaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Centro de Investigaciones del Bosque Atlántico; ArgentinaFil: de Almeida, Marco Antônio Barreto. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Alves, Rafael Souza Cruz. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Baldovino, María Celia. Centro de Investigaciones del Bosque Atlántico; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto Miguel Lillo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Di Bitetti, Mario Santiago. Centro de Investigaciones del Bosque Atlántico; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; ArgentinaFil: Oklander, Luciana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; ArgentinaFil: Holzmann, Ingrid. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Dums, Marcos. RUMO S.A. Licenciamento Ambiental; BrasilFil: Lombardi, Pryscilla Moura. RUMO S.A. Licenciamento Ambiental; BrasilFil: Bonikowski, Renata Twardowsky Ramalho. RUMO S.A. Licenciamento Ambiental; BrasilFil: Age, Stéfani Gabrieli. RUMO S.A. Licenciamento Ambiental; BrasilFil: Souza Alves, João Pedro. Universidade Federal de Pernambuco; BrasilFil: Chagas, Renata. Universidade Federal da Paraíba; BrasilFil: da Cunha, Rogério Grassetto Teixeira. Universidade Federal de Alfenas; BrasilFil: Valença Montenegro, Monica Mafra. Centro Nacional de Pesquisa e Conservaçao de Primates Brasileiros; BrasilFil: Ludwig, Gabriela. Centro Nacional de Pesquisa e Conservaçao de Primates Brasileiros; BrasilFil: Jerusalinsky, Leandro. Centro Nacional de Pesquisa e Conservaçao de Primates Brasileiros; BrasilFil: Buss, Gerson. Centro Nacional de Pesquisa e Conservaçao de Primates Brasileiros; BrasilFil: de Azevedo, Renata Bocorny. Centro Nacional de Pesquisa e Conservaçao de Primates Brasileiros; BrasilFil: Filho, Roberio Freire. Universidade Federal de Pernambuco; BrasilFil: Bufalo, Felipe. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Milhe, Louis. Université D'Avignon et des Pays du Vaucluse; FranciaFil: Santos, Mayara Mulato dos. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Sepulvida, Raíssa. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Ferraz, Daniel da Silva. Universidade do Estado de Minas Gerais; BrasilFil: Faria, Michel Barros. Universidade do Estado de Minas Gerais; BrasilFil: Ribeiro, Milton Cezar. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Galetti, Mauro. Universidade Estadual Paulista Julio de Mesquita Filho; Brasi