Synthesis and antimicrobial activity of carboxylate phosphabetaines derivatives with alkyl chains of various lengths

The purpose of the present study was to investigate the antibacterial activity of fifteen novel nanosized alkyl esters of carboxylate phosphabetaine: β-(carboxyalkyl)ethyltriphenylphosphonium bromides 4-8, β-(carboxyalkyl)-β-methylethyltriphenylphosphonium bromides 9-13, and β-(carboxyalkyl)-α-methylethyltriphenylphosphonium bromides 14-18. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive and gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate that the synthesized phosphonium salts 4-18 possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, and 31P NMR spectral studies. © 2013 Irina V. Galkina et al

Work of evacuation hospital No 2541 in the Sverdlovsk region during the Great Patriotic war

The aim of the study - is to consider the work of evacuation hospitals on the territory of the Sverdlovsk region during the Great Patriotic War. To analyze the requirements to the evacuation hospitals and the actual work of the evacuation hospital No 2541, whether the requirements met in reality.Цель исследования – рассмотреть работу эвакогоспиталей на территории Свердловской области во времена Великой Отечественной Войны. Проанализировать требования к эвакогоспиталям и фактическую работу эвакогоспиталя №2541, соответствовали ли требования в реальности

Synthesis and biological evaluation of novel carboxylate phosphabetaines derivatives with long alkyl chains

© 2016 Taylor & Francis Group, LLC.The purpose of the present study was to investigate the antibacterial activity of novel alkyl esters of carboxylate phosphabetaine: β-(carboxyalkyl)ethyltributylphosphonium bromides 4–8. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate the synthesized phosphonium salts possess a broad spectrum of activity against the testedmicroorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, 31P NMR spectral studies

Synthesis and antimicrobial activity of bis-4,6-sulfonamidated 5,7-dinitrobenzofuroxans

A new series of bis-4,6-sulfonamidated 5,7-dinitrbenzofuroxans 7-11 had been synthesized and tested for antimicrobial activity. The structures of new sulfanilamide derivatives were characterized by elemental analysis, IR spectroscopy, and mass spectrometry (MALDITOF). The synthesized compounds were tested for their in vitro antimicrobial activity using the disk diffusion method against Gram-positive bacteria Staphylococcus aureus; the Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis; the fungal strain Aspergillus niger; and the yeast-like pathogenic fungus Candida albicans. Our results indicate that the compounds 7-11 exhibit potent antimicrobial activity. The stability of the compounds was evaluated by TG and DSC methods. © 2014 Irina V. Galkina et al

Triphenylphosphine in reactions with ω-haloalkylcarboxylic acids

© 2016 Taylor & Francis Group, LLC.Stable phosphonium salts were synthesized by the phosphorylation of a series of ω-haloalkylcarboxylic acids with triphenylphosphine. In a second step the resulting phosphonium salts have been treated with 1 M aqueous solution of sodium hydroxide to form the corresponding carboxylate phosphabetaines. The structure of the isolated compounds was determined by IR and NMR spectroscopy, elemental analysis, and X-ray crystallographic studies. Their thermal stability was studied by simultaneous thermogravimetry and differential scanning calorimetry

Synthesis and structure of novel phosphorylated azomethines

© 2016 Taylor & Francis Group, LLC.The condensation of do-, hexa-, octadecan-1-amines with bromo- and nitrobenzaldehydes yielded a series of Schiff bases in good yields. Subsequent reaction of these compounds with dioctylphosphine oxide yielded phosphorylated azomethines and some were characterized using X-ray crystallography. The structure of the isolated compounds was determined by IR and NMR spectroscopy, elemental analysis, and their thermal stability was studied by simultaneous thermogravimetry and differential scanning calorimetry. All of the synthesized compounds were tested for their antibacterial and anti-Candida activity. A number of the compounds exhibited antimicrobial activity comparable to that of the commercially available drugs, ciprofloxacin and clotrimazole

ПРИМЕНЕНИЕ ПРЕПАРАТА ЭВЕЙ ДЛЯ ЛЕЧЕНИЯ КОКЦИДИОЗОВ

Efficiency of «away» at eimeriosis is studied. It is received high efficiency of the drug in a dose of 10 mg/kg at eimeriosis of chickens, rabbits and pigs. Acute toxicity of the drug is 160 mg/kg. «Away» belongs to the third class of moderately dangerous substances.Изучена эффективность препарата эвей при эймериозе. Получена высокая эффективность препарата в дозе 10 мг/кг при эймериозе цыплят, кроликов и поросят. Острая токсичность препарата составила 160 мг/кг. Эвей относится к 3 классу умеренно опасных веществ

Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies

<p>Abstract</p> <p>Background</p> <p>Vitamin D supplementation for fracture prevention is widespread despite conflicting interpretation of relevant randomised controlled trial (RCT) evidence. This study summarises quantitatively the current evidence from RCTs and observational studies regarding vitamin D, parathyroid hormone (PTH) and hip fracture risk.</p> <p>Methods</p> <p>We undertook separate meta-analyses of RCTs examining vitamin D supplementation and hip fracture, and observational studies of serum vitamin D status (25-hydroxyvitamin D (25(OH)D) level), PTH and hip fracture. Results from RCTs were combined using the reported hazard ratios/relative risks (RR). Results from case-control studies were combined using the ratio of 25(OH)D and PTH measurements of hip fracture cases compared with controls. Original published studies of vitamin D, PTH and hip fracture were identified through PubMed and Web of Science databases, searches of reference lists and forward citations of key papers.</p> <p>Results</p> <p>The seven eligible RCTs identified showed no significant difference in hip fracture risk in those randomised to cholecalciferol or ergocalciferol supplementation versus placebo/control (RR = 1.13[95%CI 0.98-1.29]; 801 cases), with no significant difference between trials of <800 IU/day and ≥800 IU/day. The 17 identified case-control studies found 33% lower serum 25(OH)D levels in cases compared to controls, based on 1903 cases. This difference was significantly greater in studies with population-based compared to hospital-based controls (χ²₁(heterogeneity) = 51.02, p < 0.001) and significant heterogeneity was present overall (χ²₁₆(heterogeneity) = 137.9, p < 0.001). Serum PTH levels in hip fracture cases did not differ significantly from controls, based on ten case-control studies with 905 cases (χ²₉(heterogeneity) = 149.68, p < 0.001).</p> <p>Conclusions</p> <p>Neither higher nor lower dose vitamin D supplementation prevented hip fracture. Randomised and observational data on vitamin D and hip fracture appear to differ. The reason for this is unclear; one possible explanation is uncontrolled confounding in observational studies. Post-fracture PTH levels are unrelated to hip fracture risk.</p