404 research outputs found
Logical Analysis of Data (LAD) model for the early diagnosis of acute ischemic stroke
<p>Abstract</p> <p>Background</p> <p>Strokes are a leading cause of morbidity and the first cause of adult disability in the United States. Currently, no biomarkers are being used clinically to diagnose acute ischemic stroke. A diagnostic test using a blood sample from a patient would potentially be beneficial in treating the disease.</p> <p>Results</p> <p>A classification approach is described for differentiating between proteomic samples of stroke patients and controls, and a second novel predictive model is developed for predicting the severity of stroke as measured by the National Institutes of Health Stroke Scale (NIHSS). The models were constructed by applying the Logical Analysis of Data (LAD) methodology to the mass peak profiles of 48 stroke patients and 32 controls. The classification model was shown to have an accuracy of 75% when tested on an independent validation set of 35 stroke patients and 25 controls, while the predictive model exhibited superior performance when compared to alternative algorithms. In spite of their high accuracy, both models are extremely simple and were developed using a common set consisting of only 3 peaks.</p> <p>Conclusion</p> <p>We have successfully identified 3 biomarkers that can detect ischemic stroke with an accuracy of 75%. The performance of the classification model on the validation set and on cross-validation does not deteriorate significantly when compared to that on the training set, indicating the robustness of the model. As in the case of the LAD classification model, the results of the predictive model validate the function constructed on our support-set for approximating the severity scores of stroke patients. The correlation and root mean absolute error of the LAD predictive model are consistently superior to those of the other algorithms used (Support vector machines, C4.5 decision trees, Logistic regression and Multilayer perceptron).</p
A Diagram Is Worth A Dozen Images
Diagrams are common tools for representing complex concepts, relationships
and events, often when it would be difficult to portray the same information
with natural images. Understanding natural images has been extensively studied
in computer vision, while diagram understanding has received little attention.
In this paper, we study the problem of diagram interpretation and reasoning,
the challenging task of identifying the structure of a diagram and the
semantics of its constituents and their relationships. We introduce Diagram
Parse Graphs (DPG) as our representation to model the structure of diagrams. We
define syntactic parsing of diagrams as learning to infer DPGs for diagrams and
study semantic interpretation and reasoning of diagrams in the context of
diagram question answering. We devise an LSTM-based method for syntactic
parsing of diagrams and introduce a DPG-based attention model for diagram
question answering. We compile a new dataset of diagrams with exhaustive
annotations of constituents and relationships for over 5,000 diagrams and
15,000 questions and answers. Our results show the significance of our models
for syntactic parsing and question answering in diagrams using DPGs
Maximum Independent Sets in Subcubic Graphs: New Results
The maximum independent set problem is known to be NP-hard in the class of
subcubic graphs, i.e. graphs of vertex degree at most 3. We present a
polynomial-time solution in a subclass of subcubic graphs generalizing several
previously known results
Contrast Mechanisms for the Detection of Ferroelectric Domains with Scanning Force Microscopy
We present a full analysis of the contrast mechanisms for the detection of
ferroelectric domains on all faces of bulk single crystals using scanning force
microscopy exemplified on hexagonally poled lithium niobate. The domain
contrast can be attributed to three different mechanisms: i) the thickness
change of the sample due to an out-of-plane piezoelectric response (standard
piezoresponse force microscopy), ii) the lateral displacement of the sample
surface due to an in-plane piezoresponse, and iii) the electrostatic tip-sample
interaction at the domain boundaries caused by surface charges on the
crystallographic y- and z-faces. A careful analysis of the movement of the
cantilever with respect to its orientation relative to the crystallographic
axes of the sample allows a clear attribution of the observed domain contrast
to the driving forces respectively.Comment: 8 pages, 8 figure
Electroresistance effects in ferroelectric tunnel barriers
Electron transport through fully depleted ferroelectric tunnel barriers
sandwiched between two metal electrodes and its dependence on ferroelectric
polarization direction are investigated. The model assumes a polarization
direction dependent ferroelectric barrier. The transport mechanisms, including
direct tunneling, Fowler-Nordheim tunneling and thermionic injection, are
considered in the calculation of the electroresistance as a function of
ferroelectric barrier properties, given by the properties of the ferroelectric,
the barrier thickness, and the metal properties, and in turn of the
polarization direction. Large electroresistance is favored in thicker films for
all three transport mechanisms but on the expense of current density. However,
switching between two transport mechanisms, i.e., direct tunneling and
Fowler-Nordheim tunneling, by polarization switching yields a large
electroresistance. Furthermore, the most versatile playground in optimizing the
device performance was found to be the electrode properties, especially
screening length and band offset with the ferroelectric.Comment: 24pages, 7 figures, revised, one figure adde
Metal-Ferroelectric-Metal heterostructures with Schottky contacts I. Influence of the ferroelectric properties
A model for Metal-Ferroelectric-Metal structures with Schottky contacts is
proposed. The model adapts the general theories of metal-semiconductor
rectifying contacts for the particular case of metal-ferroelectric contact by
introducing: the ferroelectric polarization as a sheet of surface charge
located at a finite distance from the electrode interface; a deep trapping
level of high concentration; the static and dynamic values of the dielectric
constant. Consequences of the proposed model on relevant quantities of the
Schottky contact such as built-in voltage, charge density and depletion width,
as well as on the interpretation of the current-voltage and capacitance-voltage
characteristics are discussed in detail.Comment: 14 pages with 4 figures, manuscript under revision at Journal of
Applied Physics for more than 1 year (submitted May 2004, first revision
September 2004, second revision May 2005
Dynamic Behavior in Piezoresponse Force Microscopy
Frequency dependent dynamic behavior in Piezoresponse Force Microscopy (PFM)
implemented on a beam-deflection atomic force microscope (AFM) is analyzed
using a combination of modeling and experimental measurements. The PFM signal
comprises contributions from local electrostatic forces acting on the tip,
distributed forces acting on the cantilever, and three components of the
electromechanical response vector. These interactions result in the bending and
torsion of the cantilever, detected as vertical and lateral PFM signals. The
relative magnitudes of these contributions depend on geometric parameters of
the system, the stiffness and frictional forces of tip-surface junction, and
operation frequencies. The dynamic signal formation mechanism in PFM is
analyzed and conditions for optimal PFM imaging are formulated. The
experimental approach for probing cantilever dynamics using frequency-bias
spectroscopy and deconvolution of electromechanical and electrostatic contrast
is implemented.Comment: 65 pages, 15 figures, high quality version available upon reques
Ferroelectric Nanotubes
We report the independent invention of ferroelectric nanotubes from groups in
several countries. Devices have been made with three different materials: lead
zirconate-titanate PbZr1-xTixO3 (PZT); barium titanate BaTiO3; and strontium
bismuth tantalate SrBi2Ta2O9 (SBT). Several different deposition techniques
have been used successfully, including misted CSD (chemical solution
deposition) and pore wetting. Ferroelectric hysteresis and high optical
nonlinearity have been demonstrated. The structures are analyzed via SEM, TEM,
XRD, AFM (piezo-mode), and SHG. Applications to trenching in Si dynamic random
access memories, ink-jet printers, and photonic devices are discussed.
Ferroelectric filled pores as small as 20 nm in diameter have been studied
- …