Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study.

Although clopidogrel reduces the incidence of atherothrombotic events, its use is associated with an increased risk of major bleeding. Cerebral microbleeds (CMBs) are indicative of subclinical microangiopathy in the brain and may prelude symptomatic intracerebral hemorrhage. We examined the association between use of clopidogrel and CMBs in persons without a history of stroke. We performed a cross-sectional analysis using data from the Rotterdam Study, a prospective population-based cohort of persons aged 45 years and older. Among 4408 stroke-free individuals who underwent brain magnetic resonance imaging for the detection of CMBs, we identified 121 ever-users and 4287 never-users of clopidogrel before magnetic resonance imaging. We used multiple logistic regression to analyze the association between clopidogrel and CMBs with adjustment for age, sex, cardiovascular risk factors, and common cardiovascular medication. Users of clopidogrel had a higher prevalence of CMBs (odd ratio 1.55, 95% CI 1.01 to 2.37) than nonusers and more often had a high number (> 4) of CMBs (odds ratio 3.19, 95% CI 1.52 to 6.72). Clopidogrel use was associated with a significantly higher prevalence of deep or infratentorial CMBs (odd ratio 1.90, 95% CI 1.05 to 3.45). Among clopidogrel users, we were unable to demonstrate differences in the prevalence of CMBs by indication of prescription, history of coronary heart disease, or common genetic variants in CYP2C19. In stroke-free individuals, clopidogrel use was associated with a higher prevalence and higher number of CMBs. Whether this association is causal requires confirmation in prospective studies, especially given the small number of participants taking clopidogrel and the possibil

Genetic loci for serum lipid fractions and intracerebral hemorrhage

Background: Serum total cholesterol and its fractions are inversely associated with intracerebral hemorrhages (ICH) and their potential subclinical precursor, cerebral microbleeds. To ascertain whether there is a genetic basis for this inverse association, we studied established genetic loci for serum total, LDL, and HDL cholesterol, and triglycerides in their association with ICH and microbleeds. Methods: Data on 161 genetic variants for serum lipids was collected in 9011 stroke-free participants (mean age 65.8, SD 10.2; 57.9% women) of the population-based Rotterdam Study. Participants were followed from baseline (1997-2005) up to 2013 for the occurrence of ICH. A subset of 4179 participants underwent brain MRI for microbleed assessment between 2005 and 2011. We computed genetic risk scores (GRS) for the joint effect of lipid variants. Cox proportional hazards and logistic regression models were used to investigate the association of GRS of lipid fractions with ICH and microbleeds. Results: After a mean follow-up of 8.7 (SD 4.1) years, 67 (0.7%) participants s

Électrosynthèse du poly(3,4-éthylènedioxythiophène) à partir d'un précurseur bithiophénique

Le 2,2'-éthylènedioxybithiophène a été synthétisé et utilisé comme précurseur pour l'électropolymérisation. Les propriétés électrochimiques et spectroscopiques du polymère obtenu sont très proches de celle du poly(3,4-éthylènedioxythiophène). Cependant, l'électropolymérisation du dimère s'effectue à un potentiel inférieur de 0.65V à celui du monomère

Nouveaux systèmes conjugués à états redox multiples

International audienc

Nouveaux systèmes conjugués à états redox multiples

De nouveaux systèmes conjugués linéaires basés sur l'association de donneurs thiophéniques et du tétracyanoindane préparé à partir de l'indan-1,3-dione ont été synthétisés. Les données optiques et électrochimiques révèlent un fort pouvoir accepteur d'électrons ainsi qu'un faible écart HOMO-LUMO