The role of psychosocial safety climate on flexible work from home digital job demands and work-life conflict

Due to the COVID-19 pandemic, the number of employees in flexible work from home has increased markedly along with a reliance on information communication technologies. This study investigated the role of an organisational factor, psychosocial safety climate (PSC; the climate for worker psychological health and safety), as an antecedent of these new kinds of demands (specifically work from home digital job demands) and their effect on work-life conflict. Data were gathered via an online survey of 2,177 employees from 37 Australian universities. Multilevel modelling showed that university level PSC to demands, y=−0.09, SE=0.03, p<0.01, and demands to worklife conflict, y=0.51, SE=0.19, p<0.05, relationships were significant. Supporting the antecedent theory, university level PSC was significantly indirectly related to work-life conflict via demands (LL −0.10 UL −0.01). Against expectations PSC did not moderate the demand to work-life conflict relationship. The results imply that targeting PSC could help prevent work from home digital job demands, and therefore, work-life conflict. Further research is needed on the role of digital job resources as flexible and hybrid work takes hold post COVID.Amy K. Parkin, Amy J. Zadow, Rachael E. Potter, Ali Afsharian, Maureen F. Dollard, Silvia Pignata, Arnold B. Bakker, And Kurt Lushingto

Seroepidemiology of hepatitis C in Kermanshah (West of Iran, 2006)

Background and Aims: Chronic and serious outcomes of hepatitis C virus (HCV) infection impose remarkable economic burden to the health system. The aim of this study was to evaluate the prevalence of HCV infection in the general population of Kermanshah in the year 2006. Methods: In this cross-sectional study, 1721 residents from Kermanshah were chosen by systematic and cluster sampling in the year 2006. After interview, serum samples were taken and evaluated for HCV-Ab using ELISA method (3rd generation). Positive samples were confirmed by Western Blot (WB) and PCR if necessary. Results: The prevalence of HCV was 0.87 (male: 1.4 vs. female: 0.3). There was 88.2 coordination between ELISA and WB results. Statistical relationship was observed between HCV infection and male sex (P<0.018), history of addiction (P<0.0001), shared needle (P<0.0001), unsafe sexual contact (P<0.008), history of blood and blood products transfusion (P<0.0001), tattooing (P<0.0001), history of incarceration (P<0.0001), and hemophilia (P<0.0001). On the other hand, stepwise logistic regression analysis showed that hemophilia, shared needle, IV addiction, transfusion and addiction were the most important risk factors for HCV infection in a descending order. The rate of HCV infection increased in cases with multiple risk factors. Conclusions: We estimate that among 967196 people, who live in Kermanshah, nearty 8400 individuals may have HCV infection and this will be a major problem in the near future. Addicts especially IV drug users and cases with the history of blood and blood products transfusion are high risk groups who need special attention regarding HCV infection

MIC susceptility testing of nosocomial infections at PICU in Children's Medical Center, Iran

Background: The aim of this study was to determine the minimal inhibitory concentration (MIC) of microorganisms causing nosocomial infections in the pediatric intensive care unit (PICU) of the Children's Medical Center in Tehran. Methods: All patients with nosocomial infections in the PICU were enrolled in the study. Causative microoraganisms were coagulase positive, and coagulase negative Staphylococci and Pseudomonas aeruginosa . MIC of many antibiotics was determined by microbroth dilution according to NCCLS. Findings: Within a period of 18 months, thirty patients developed nosocomial infection including 17 cases with P.aeruginosa and 9 individuals with Staph aureus infection. The remaining 4 patients were involved with coagulase negative Staphylococci. The most common sources were respiratory tract, blood stream, wound and soft tissue. Multi-antimicrobial resistance (resistance to Amikacin, Ceftazidim, Imipenem and Ciprofloxacin) was common among P. aeruginosa species All strains of Staph aureus were resistant to Methicillin (MRSA). These microorganisms were also resistant to clindamycin and ciprofloxacin in 88% of cases.Conclusion: Resistance to antimicrobial agents was high in our study, therefore routine MIC examination is necessary in PICU

The role of psychosocial safety climate on flexible work from home digital job demands and work-life conflict

Due to the COVID-19 pandemic, the number of employees in flexible work from home has increased markedly along with a reliance on information communication technologies. This study investigated the role of an organisational factor, psychosocial safety climate (PSC; the climate for worker psychological health and safety), as an antecedent of these new kinds of demands (specifically work from home digital job demands) and their effect on work-life conflict. Data were gathered via an online survey of 2,177 employees from 37 Australian universities. Multilevel modelling showed that university level PSC to demands, y=-0.09, SE=0.03, p&lt;0.01, and demands to work-life conflict, y=0.51, SE=0.19, p&lt;0.05, relationships were significant. Supporting the antecedent theory, university level PSC was significantly indirectly related to work-life conflict via demands (LL -0.10 UL -0.01). Against expectations PSC did not moderate the demand to work-life conflict relationship. The results imply that targeting PSC could help prevent work from home digital job demands, and therefore, work-life conflict. Further research is needed on the role of digital job resources as flexible and hybrid work takes hold post COVID.</p

Evaluation of Toll-like receptor 3 (TLR3) signaling pathway genes and its genetic polymorphisms in ectopic and eutopic endometrium of women with endometriosis

Objective: Toll-like receptors (TLRs, as members of the innate immune system) are expressed in the human endometrium and their aberrant regulation and expression are involved in the pathogenesis of endometrial diseases. This study is aimed at evaluation of TLR3 signaling pathway genes and its genetic changes in endometriosis patients. Materials and methods: Blood samples were collected from 83 endometriosis patients and 93 healthy fertile women and PCR was performed in blood-derived DNA for detection of SNP of TLR3. Also, ectopic (EC) and eutopic (EU) endometrial biopsies were obtained from endometriosis patients (n = 20), as well as endometrium from healthy women (n = 16, CE). Q-PCR was performed for determination of mRNA expression level of TLR3 signaling pathway genes (TLR3, TICAM, NF-kB1A, CXCL10, IRF3, IFN-B1, IL-6 and IL-8). Also, serum protein levels of TLR3, IFN-β, IL-6 and IL-8 were determined using ELISA. Results: The mRNA expression levels of TLR3, NF-kB1A, IFN-B1, IRF3, TICAM1, IL-6 and IL-8 were significantly higher in EU compared to ectopic ones and also compared to CE. SNPs frequency (rs3775291 and rs3775290) was not significantly different between patients and controls. Serum protein levels of TLR3, IFN-β, IL-6 and IL-8 were significantly increased in endometriosis patients. Conclusion: Significant changes were observed in the expression of IL-6 and IL-8 cytokines and other genes in TLR3 cascade in diseased EU, demonstrating that EU similarly to EC is in an intensive inflammatory state. These fundamental alterations in the concept of immune response in EU may lead to its activation, escapes from apoptosis, and displaced implantation of the endometrium. © 2021 Elsevier Masson SA

Neurological Manifestations of Hospitalized Patients with Covid-19: A Case Series Study

There are some reports about the neurological manifestations and complications of COVID-19. We present neurological manifestations in 6 hospitalized patients with COVID-19. The patients presented with common symptoms of COVID-19 along with common findings from high-resolution computed tomography (HRCT) scan such as ground-glass opacities (GGOs). Though, RT-PCR testing of SARS-CoV-2 was negative for all 6 cases. In the current report, acute cerebrovascular diseases affected older patients, while dementia, seizure and encephalopathy affected younger ones. Three of the 6 patients had proven strokes based on their neuroimaging. Four of the 6 patients had high d-dimer levels. Two of the cases experienced convulsion. The third patient presented with typical symptoms and signs of neuroleptic malignant syndrome. The sixth case was interesting for transient dementia. Unfortunately, four out of six patients died. The recent case series report the association between neurological involvements and COVID-19 infection. Clinicians should be alert of the neurologic symptoms in the setting of COVID-19, which might even be the first presentations of this infection