Bone marrow transplantation alters the tremor phenotype in the murine model of globoid-cell leukodystrophy

Tremor is a prominent phenotype of the twitcher mouse, an authentic genetic model of Globoid-Cell Leukodystrophy (GLD, Krabbe’s disease). In the current study, the tremor was quantified using a force-plate actometer designed to accommodate low-weight mice. The actometer records the force oscillations caused by a mouse’s movements, and the rhythmic structure of the force variations can be revealed. Results showed that twitcher mice had significantly increased power across a broad band of higher frequencies compared to wildtype mice. Bone marrow transplantation (BMT), the only available therapy for GLD, worsened the tremor in the twitcher mice and induced a measureable alteration of movement phenotype in the wildtype mice. These data highlight the damaging effects of conditioning radiation and BMT in the neonatal period. The behavioral methodology used herein provides a quantitative approach for assessing the efficacy of potential therapeutic interventions for Krabbe’s disease

Theory of Large Intrinsic Spin Hall Effect in Iridate Semimetals

We theoretically investigate the mechanism to generate large intrinsic spin Hall effect in iridates or more broadly in 5d transition metal oxides with strong spin-orbit coupling. We demonstrate such a possibility by taking the example of orthorhombic perovskite iridate with nonsymmorphic lattice symmetry, SrIrO3, which is a three-dimensional semimetal with nodal line spectrum. It is shown that large intrinsic spin Hall effect arises in this system via the spin-Berry curvature originating from the nearly degenerate electronic spectra surrounding the nodal line. This effect exists even when the nodal line is gently gapped out, due to the persistent nearly degenerate electronic structure. The magnitude of the spin Hall conductivity is shown to be comparable to the best known example such as doped topological insulators and the biggest in any transition metal oxides. To gain further insight, we compute the intrinsic spin Hall conductivity in both bulk and thin film systems. We find that the geometric confinement in thin films leads to significant modifications of the electronic states, leading to even bigger spin Hall conductivity in certain cases. We compare our findings with the recent experimental report on the discovery of large spin Hall effect in SrIrO3 thin films.11Ysciescopu

Study on interventions to reduce vibration transmission to power tiller operator

Present study focuses on interventions to reduce vibration transmitted to power tiller operator. In this study two operations (namely: standing mode and transportation) and three forward speeds (1.0, 1.5 and 2.0 kmh-1) were selected. In both selected operations vibration magnitudes were maximum at 2.0 kmh-1. In the standing mode vibration magnitudes in x, y and z direction were 5.83, 1.37 and 2.36 ms -2 at 2.0 kmh-1. In transportation vibration magnitudes were 6.81, 1.49, 2.82 ms-2 respectively in x, y and z direction at 2.0 kmh-1. The selection of vibration isolators were done on the basis of the transmissibility curves and the isolation region. The selected isolators were installed at interface between engine and the chassis. These interventions along with previously developed bush and sheet type interventions reduced vibrations up to 50.24, 69.06 and 59.08 % at 1.0, 1.5 and 2.0 kmh-1 in stationary mode. In transportation vibration reduction were 52.96, 65.98 and 36.67 % at 1.0, 1.5 and 2.0 kmh-1, respectively. The vibration reduction were high in stationary mode than transportation mode because in stationary mode vibration comes only from the engine but in transportation vibration comes from engine and the surface profile as well

Duty ratio control ofthree port isolated bidirectional asymmetrical triple active bridge DC-DC converter

Multiport converters are used in interfacing of distributed energy sources with grid/load. Isolated converters are needed in applications where converter gain is high and there is a requirement of isolation. Dual transformer asymmetric triple active bridge offers the advantage of reduced circulating current. However, the operating range is low for variation in load and source voltage. In this paper duty ratio modulation technique is proposed to regulate the load voltage and control the power flow in both the directions. As a result of the new gating scheme, the converter switches operate with ZVS, irrespective of variations in load power and source voltage. The converter is designed to ensure high switch utilization. The control technique is validatedthrough simulation of a 1kW three port DC-DC converter. It was observerd that the load voltage was regulated for wide range of variation in load power and source port voltages. The single input dual output mode was also verified