The effects of donepezil in Alzheimer's disease - Results from a multinational trial

Donepezil has been shown to be well tolerated and to improve cognition and global function in patients with mild to moderately severe Alzheimer's disease (AD). The current trial was undertaken to investigate further the efficacy and safety of donepezil, in a multinational setting, in patients with mild to moderately severe AD. This 30-week, placebo-controlled, parallel-group study consisted of a 24-week, double-blind treatment phase followed by a 6-week, single-blind, placebo washout. Eight hundred and eighteen patients with mild to moderately severe AD were randomly allocated to treatment with single, daily doses of 5 or 10 mg donepezil, or placebo. The two primary efficacy measures were: a cognitive performance test, the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and a global evaluation, the Clinician's Interview-Based Impression of Change with caregiver input (CIBIC plus). Secondary outcome measures included the Sum of the Boxes of the Clinical Dementia Rating Scale (CDR-SB), a modified Interview for Deterioration in Daily living activities in Dementia (IDDD) and a patient-rated quality of life assessment. Statistically significant improvements in cognitive and global function were observed, as evaluated by ADAS-cog and CIBIC plus, respectively, in both the 5 and 10 mg/day donepezil groups, compared with placebo. Treatment-associated changes were also observed in functional skills, as shown by improved scores on the CDR-SB and the complex-tasks component of the IDDD. A dose-response effect was evident, with the 10 mg/day donepezil group demonstrating greater benefits in all outcome measures than the 5 mg/day group. Donepezil was well tolerated by this patient population and did not produce any clinically significant laboratory test abnormalities. The results of this study confirm that donepezil is effective and well tolerated in treating the symptoms of mild to moderately severe AD

Collective excitations of a degenerate gas at the BEC-BCS crossover

We study collective excitation modes of a fermionic gas of $^6$Li atoms in the BEC-BCS crossover regime. While measurements of the axial compression mode in the cigar-shaped trap close to a Feshbach resonance confirm theoretical expectations, the radial compression mode shows surprising features. In the strongly interacting molecular BEC regime we observe a negative frequency shift with increasing coupling strength. In the regime of a strongly interacting Fermi gas, an abrupt change in the collective excitation frequency occurs, which may be a signature for a transition from a superfluid to a collisionless phase.Comment: Feshbach resonance position updated, few minor change

Speech Communication

Contains reports on six research projects.U. S. Air Force Command and Control Development Division under Contract AF19(604)-6102National Science Foundatio

The European citizen science landscape – a snapshot

Citizen science, the active participation of the public in scientific research projects, is a rapidly expanding field in open science and open innovation. It provides an integrated model of public knowledge production and engagement with science. As a growing worldwide phenomenon, it is invigorated by evolving new technologies that connect people easily and effectively with the scientific community. Catalysed by citizens’ wishes to be actively involved in scientific processes, as a result of recent societal trends, it also offers contributions to the rise in tertiary education. In addition, citizen science provides a valuable tool for citizens to play a more active role in sustainable development. This book identifies and explains the role of citizen science within innovation in science and society, and as a vibrant and productive science-policy interface. The scope of this volume is global, geared towards identifying solutions and lessons to be applied across science, practice and policy. The chapters consider the role of citizen science in the context of the wider agenda of open science and open innovation, and discuss progress towards responsible research and innovation, two of the most critical aspects of science today

Conductance fluctuations in mesoscopic normal-metal/superconductor samples

We study the magnetoconductance fluctuations of mesoscopic normal-metal/superconductor (NS) samples consisting of a gold-wire in contact with a niobium film. The magnetic field strength is varied over a wide range, including values that are larger than the upper critical field B_c2 of niobium. In agreement with recent theoretical predictions we find that in the NS sample the rms of the conductance fluctuations (CF) is by a factor of 2.8 +/- 0.4 larger than in the high field regime where the entire system is driven normal conducting. Further characteristics of the CF are discussed.Comment: 4 pages, REVTEX, 3 eps-figures included. To be published in Phys. Rev. Lett.. Changes: one misplaced figure correcte

Speech Communication

Contains research objectives and reports on two research projects.U.S. Air Force (Electronic Systems Division) under Contract AF19(604)-6102National Science Foundation (Grant G-10800)National Science Foundation (Grant G-7364)National Science Foundation (Grant G-16526)National Institutes of Health (Grant MP-4737

Towards Runtime Verification of Programmable Switches

Is it possible to patch software bugs in P4 programs without human involvement? We show that this is partially possible in many cases due to advances in software testing and the structure of P4 programs. Our insight is that runtime verification can detect bugs, even those that are not detected at compile-time, with machine learning-guided fuzzing. This enables a more automated and real-time localization of bugs in P4 programs using software testing techniques like Tarantula. Once the bug in a P4 program is localized, the faulty code can be patched due to the programmable nature of P4. In addition, platform-dependent bugs can be detected. From P4_14 to P4_16 (latest version), our observation is that as the programmable blocks increase, the patchability of P4 programs increases accordingly. To this end, we design, develop, and evaluate P6 that (a) detects, (b) localizes, and (c) patches bugs in P4 programs with minimal human interaction. P6 tests P4 switch non-intrusively, i.e., requires no modification to the P4 program for detecting and localizing bugs. We used a P6 prototype to detect and patch seven existing bugs in eight publicly available P4 application programs deployed on two different switch platforms: behavioral model (bmv2) and Tofino. Our evaluation shows that P6 significantly outperforms bug detection baselines while generating fewer packets and patches bugs in P4 programs such as switch.p4 without triggering any regressions

Fractal Conductance Fluctuations in Gold--Nanowires

A detailed analysis of magneto-conductance fluctuations of quasiballistic gold-nanowires of various lengths is presented. We find that the variance $=$ when analyzed for $\Delta B$ much smaller than the correlation field $B_c$ varies according to $<(\Delta G)^2>\propto \Delta B^{\gamma}$ with $\gamma < 2$ indicating that the graph of $G$ vs. $B$ is fractal. We attribute this behavior to the existence of long-lived states arising from chaotic trajectories trapped close to regular classical orbits. We find that $\gamma$ decreases with increasing length of the wires.Comment: 5 pages, Revtex with epsf, 4 Postscript figures, final version accepted as Phys. Rev. Let

Attractively bound pairs of atoms in the Bose-Hubbard model and antiferromagnetism

We consider a periodic lattice loaded with pairs of bosonic atoms tightly bound to each other via strong attractive on-site interaction that exceeds the inter-site tunneling rate. An ensemble of such lattice-dimers is accurately described by an effective Hamiltonian of hard core bosons with strong nearest-neighbor repulsion which is equivalent to the $XXZ$ model with Ising-like anisotropy. We calculate the ground-state phase diagram for a one-dimensional system which exhibits incompressible phases, corresponding to an empty and a fully filled lattice (ferromagnetic phases) and a half-filled alternating density crystal (anti-ferromagnetic phase), separated from each other by compressible phases. In a finite lattice the compressible phases show characteristic oscillatory modulations on top of the anti-ferromagnetic density profile and in density-density correlations. We derive a kink model which provides simple quantitative explanation of these features. To describe the long-range correlations of the system we employ the Luttinger liquid theory with the relevant Luttinger parameter $K$ obtained exactly using the Bethe Ansatz solution. We calculate the density-density as well as first-order correlations and find excellent agreement with numerical results obtained with density matrix renormalization group (DMRG) methods. We also present a perturbative treatment of the system in higher dimensions.Comment: 10 pages, 9 figure

Patient engagement with antibiotic messaging in secondary care: a qualitative feasibility study of the ‘review & revise’ experience

Background: We aimed to investigate and optimise the acceptability and usefulness of a patient leaflet about antibiotic prescribing decisions made during hospitalisation, and to explore individual patient experiences and preferences regarding the process of antibiotic prescription ‘review & revise’ which is a key strategy to minimise antibiotic overuse in hospitals. Methods: In this qualitative study, run within the feasibility study of a large, cluster-randomised stepped wedge trial of 36 hospital organisations, a series of semi-structured, think-aloud telephone interviews were conducted and data were analysed using thematic analysis. Fifteen adult patients who had experienced a recent acute medical hospital admission during which they had been prescribed antimicrobials and offered a patient leaflet about antibiotic prescribing were recruited to the study. Results: Participants reacted positively to the leaflet, reporting that it was both an accessible and important source of information which struck the appropriate balance between informing and reassuring. Participants all valued open communication with clinicians, and were keen to be involved in antibiotic prescribing decisions, with individuals reporting positive experiences regarding antibiotic prescription changes or stopping. Many participants had prior experience or knowledge of antibiotics and resistance, and generally welcomed efforts to reduce antibiotic usage. Overall, there was a feeling that healthcare professionals (HCPs) are trusted experts providing the most appropriate treatment for individual patient conditions. Conclusions: This study offers novel insights into how patients within secondary care are likely to respond to messages advocating a reduction in the use of antibiotics through the ‘review & revise’ approach. Due to the level of trust that patients place in their care provider, encouraging HCPs within secondary care to engage patients with greater communication and information provision could provide great advantages in the drive to reduce antibiotic use. It may also be beneficial for HCPs to view patient experiences as cumulative events that have the potential to impact future behaviour around antibiotic use. Finally, pre-testing messages about antibiotic prescribing and resistance is vital to dispelling any misconceptions either around effectiveness of treatment for patients, or perceptions of how messages may be received