Strong coupling constants of bottom and charmed mesons with scalar, pseudoscalar and axial vector kaons

The strong coupling constants, $g_{D_{s}DK_0^*}$, $g_{B_{s}BK_0^*}$, $g_{D^{\ast}_{s}D K}$, $g_{B^{\ast}_{s}BK}$, $g_{D^{\ast}_{s}D K_1}$ and $g_{B^{\ast}_{s}BK_1}$, where $K_0^*$, $K$ and $K_1$ are scalar, pseudoscalar and axial vector kaon mesons, respectively are calculated in the framework of three-point QCD sum rules. In particular, the correlation functions of the considered vertices when both $B(D)$ and $K_0^*(K)(K_1)$ mesons are off-shell are evaluated. In the case of $K_1$, which is either $K_1(1270)$ or $K_1(1400)$, the mixing between these two states are also taken into account. A comparison of the obtained result with the existing prediction on $g_{D^{\ast}_{s}D K}$ as the only coupling constant among the considered vertices, previously calculated in the literature, is also made.Comment: 20 Pages, 3 Figures and 8 Table

The effects of pregabalin on kidney tissue of the rats those have ureter obstruction [Üreter Obstrüksiyonu yapılan ratlarda pregabalinin Böbrek Dokusu üzerine etkileri]

Background: Various algorithms and treatment guidelines have been established for the treatment of neuropathic pain. In summary, tricyclic antidepressants, anticonvulsants, serotonin reuptake inhibitors and opioids are used in these algorithms. Pregabalin is an anticonvulsant drug that is frequently used in the treatment of neuropathic pain. During the use of kidneys in patients with renal insufficiency due to the need to change the dose was taken attention. Therefore, in our study, we aimed to investigate the effects of pregabalin on renal tissue in rats with renal failure due to ureter obstruction. Materials and Methods: After the approval of the ethics committee, 24 rats were randomly divided into four groups: Group C: Control, Group P: Pregabalin, Group UO: Ureter Obstruction, UO-P Group: Ureter Obstruction - Pregabalin. Urinary obstruction groups underwent a low abdominal incision under ketamine anesthesia to reach the distal right ureter and suture was placed with 2.0 mersilene and was waited for 3 weeks for late stage renal failure. In group P and UO-P rats, pregabalin was administered intraperitoneally at a dose of 100 mg / kg. After the twenty-four hour followup period, rats were sacrificed with the blood taken from the intraabdominal aorta by intraperitoneal ketamine (100 mg / kg). Blood samples were stored at -20 ° C and urea, creatinine, MDA and NO were studied. In the kidney tissue, caspase 3, 8 enzymes and histopathological evaluation were performed. Results: Caspase 3 enzyme activity was significantly increased in UO groups. In addition, pregabalin administration significantly increased the activity of caspase 3 in the UO-P group compared to the P group. The enzyme activity of caspase 8 was similar between the groups. Light microscopy revealed significant changes in UO groups, especially in the kidney tissue, which was obstructed. NO and MDA enzyme activities increased significantly in UO groups. In addition, pregabalin administration significantly increased NO and MDA enzyme activities in UO-P group compared to P group. Urinary obstruction significantly increased urea and creatinine levels. Pregabalin administration also increased urea and creatinine levels in the UO-P group compared to the P group. Conclusion: Pregabalin, which is frequently used in the treatment of neuropathic pain, has not been found to increase the renal damage that occurs experimentally in renal failure rats. We believe that our findings should be supported by a wide range of experimental and clinical studies. © Copyright 2019 by Gazi University Medical Faculty

Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction

Işın Güneş,1 Nuran Süngü,2 Aydan Kılıçarslan,2 Volkan Şıvgın,3 Metin Alkan,3 Ayşegül Küçük,4 Hakan Boyunağa,5 Yusuf Ünal,3 Mustafa Arslan3 1Department of Anaesthesiology and Reanimation, Erciyes University Medical Faculty, Kayseri, Turkey; 2Department of Pathology, Yıldırım Beyazıt University Medical Faculty, Ankara, Turkey; 3Department of Anaesthesiology and Reanimation, Gazi University Medical Faculty, Ankara, Turkey; 4Department of Physiology, Dumlupinar University Medical Faculty, Kütahya, Turkey; 5Department of Biochemistry, Kirikkale University Medical Faculty, Kirikkale, Turkey Objective: This study was conducted since the effects of colloid solutions on the renal system remain controversial and need to be adequately studied in animals. We aimed to evaluate the effects of hydroxyethyl starch (Voluven) on the kidney tissue of rats with late renal failure due to ureteral obstruction. Materials and methods: Rats were divided into four groups: Group C, control; Group HES, hydroxyethyl starch solution (HES) 130/0.4 (Voluven®); Group UUO, unilateral ureteral obstruction (UUO); and Group UUO-HES, UUO-HES 130/0.4 (Voluven®). In the groups with ureteral obstruction, the distal part of the right ureter was accessed and sutured through a lower abdominal incision under ketamine anesthesia. Any signs of late-stage renal failure were evaluated after three weeks. Rats in the HES group and the renal failure-HES group were administered with HES 130/0.4 as a single intravenous dose of 20 mL/kg. After a follow-up of 24 hours, intra-abdominal blood sample was collected, and the rats were sacrificed. Biochemical and histopathological parameters were then evaluated. Results: Ureteral obstruction significantly increased urea and creatinine levels. In addition, when the UUO-HES and HES groups were compared, the administration of HES increased urea and creatinine levels in the UUO-HES group. Nitric oxide enzyme activity and malondialdehyde levels have significantly increased in the UUO groups. In addition, HES significantly increased nitric oxide activity and malondialdehyde levels in the UUO-HES group, in comparison with the HES group. The activity of caspases 3 and 8 was significantly increased in the UUO groups. In addition, HES significantly increased the activity of caspases 3 and 8 in the UUO-HES group, in comparison with the HES group. Light microscopy revealed significant changes in the UUO groups, especially in the obstructed kidneys. Conclusion: If indicated, HES should be used with caution in cases of UUO, but not in the cases of bilateral ureteral obstruction. Other aspects of these findings, including the clinical significance and practical applications, merit further experimental and clinical investigation. Keywords: unilateral ureteral obstruction, hydroxyethyl starch solution 130/0.4, caspase 3, caspase 8, malondialdehyde, nitric oxid