A Case of Ameloblastic Fibroodontoma Extending Maxillary Sinus with Erupted Tooth: Is Transcanine Approach with Alveolectomy Feasible?

Ameloblastic fibroodontoma (AFO) is a rare entity of mixed odontogenic tumors and frequently arises from posterior portion of the maxilla or mandible in first two decades of life. Herein, a 35-year-old woman with a noncontributory medical history who presented with a progressive left maxillary toothache, left maxillary first molar tooth mobility, and swelling in the left maxillary molar area for the last 2 months was reported. Radiologically, a tumor that originated from periapical area of the second mature molar teeth of maxilla was seen and additively unerupted tooth was not detected. The histopathologic examination revealed AFO. The patient is disease-free for five years after treated with limited segmental alveolectomy combining with Caldwell-Luc procedure

Recurrent Parotid Pleomorphic Adenomas: Our Clinical Experience

Objective:The aim of our study was to present our findings in a series of patients who were treated for recurrent parotid pleomorphic adenoma with their clinical, surgical, and follow-up information and to discuss them in light of the recent literature.Methods:Eleven patients who had revision surgery for recurrent pleomorphic adenoma at our institution were retrospectively analyzed for the clinical and radiological features of their lesions, surgery type, facial nerve management, and follow-up period.Results:Seven patients were females and four were males with an average age of 45 years. All patients underwent previous surgeries at other institutions. Revision surgery was performed with superficial parotidectomy in six patients and total conservative parotidectomy with preservation of the facial nerve in five patients. Two patients had lesions involving the facial nerve branches necessitating sacrifice of involved branches. One patient was given adjuvant radiotherapy because of adjacent lymphatic vessel involvement with tumor cells. During the mean follow-up period of 9.1 years, there were no recurrences in any of the patients.Conclusion:Management of patients with recurrent parotid pleomorphic adenomas must be carefully planned according to the size, location, and multicentricity of the tumor and involvement of the facial nerve. Surgery should aim at reaching tumor-free surgical margins. Sacrifice of the facial nerve should be considered only in cases with direct involvement. In the postoperative period, patients must be followed up regularly for early diagnosis of recurrences

Myxoma of the Middle Ear Mimicking Chronic Otitis Media

Myxoma is a benign connective tissue tumor that arises mostly from the heart. Temporal bone myxomas are extremely rare and these patients should be evaluated for the Carney complex association. Herein, our aim was to present a middle ear myxoma case operated with an initial diagnosis of chronic otitis media (COM) and to underline the fact that myxomas should be kept in mind in the differential diagnosis of aural polyps

Role of Elective Neck Dissection in Early Stage Lip Cancers

Objective:To date, the management of the neck in early stage lower lip cancers remains controversial. The aim of this study is to investigate if prophylactic neck dissection is necessary in early stage lower lip cancers.Methods:Charts of 11 patients who underwent surgery of the primary site and neck because of T1–2N0 lower lip cancer between 1997 and 2011 were retrospectively examined. Clinical stages, surgeries, histopatological examination results, and loco-regional recurrences were evaluated.Results:Of the 11 patients, 10 were male (90.9%) and 1 was female (9.09%). The follow-up time of these patients was between 24-168 months (mean, 56.6 months). There were 5 patients with clinically diagnosed T1N0 tumors and 6 patients with clinically diagnosed T2N0 tumors. Suprahyoid neck dissection was performed in 4/5 T1N0 patients and supraomohyoid neck dissection was performed in the remaining 1 patient. For T2N0 tumors, 4 suprahyoid, 1 supraomohyoid, and 1 comprehensive neck dissection was performed. Histopathological examination revealed no occult metastasis in any of the patients. In 1 patient who had lower lip resection and suprahyoid neck dissection for T1N0 lower lip cancer, a contralateral neck metastasis was detected 22 months postsurgery, and a comprehensive neck dissection was performed.Conclusion:Our results show that in patients with T1N0 lower lip tumors, neck dissection may not be necessary; however, close follow-up is mandatory. Further researches with larger series dividing T2N0 tumors into subgroups for tumor size and thickness are necessary to determine neck treatment in these tumors

Assessment of Subepithelial Angiogenesis in Acquired Cholesteatoma between Pediatric and Adult Patients

Objective:The aim of this study was to compare subepithelial angiogenesis developing within the perimatrix of the cholesteatoma between pediatric and adult patients.Methods:Sixty-one patients who underwent mastoidectomy for the first intent because of chronic otitis media with cholesteatoma between 1993 and 2013 and from whom appropriate tissue specimens were taken were included in the study. The patients were classified in the pediatric patient group if they were under the age of 18 years and the adult patient group if they were 18 years and older. Immunohistochemical staining for CD-31 was performed on new sections taken during surgery and sections prepared from archived tissues in paraffin blocks. Results were compared between the groups.Results:A total of 61 patients, of whom 25 were pediatric and 36 were adult patients, were included in the study. The mean CD-31 immunopositive microvessel rates were 8.8 (3-15) and 6.61 (2-14) for the pediatric and adult patient groups, respectively. The difference between the groups was statistically significant (p=0.037). Correlation analysis showed a statistically significant negative correlation between the CD-31 immunopositive microvessel rates and age (p=0.036).Conclusion:Subepithelial angiogenesis developing within the perimatrix of the cholesteatoma of the pediatric patients was more expressed than that of the adult patients

MOLEKÜLER PATOLOJİ LABORATUVAR YÖNTEMLERİ VE BİYOİNFORMATİK YAKLAŞIM

"Moleküler Patoloji Laboratuvar Yöntemleri ve Biyoinformatik Yaklaşım" kitabı birçok yazar tarafından çok emek verilerek oluşturuldu. Dokuz Eylül SBE Moleküler Patoloji AD öğretim üyeleri ve doktora öğrencileri olarak zevkli bir çalışma yapmanın mutluluğunu yaşadık. Bu kitap rutin işleyişi için oldukça kapsamlı olsa da moleküler patoloji alanındaki gelişmeler o kadar hızlı ve çeşitli ki eksiklerinin de olduğunu ön görmek gerçekçi olacaktır. Diliyorum ki anadilimizdeki&nbsp;yeni kitaplar bu boşlukları en yakın zamanda doldursun. Daha önce 2015 yılındaki&nbsp; Barlett JM, Shaaban A, Schmitt F editörlüğünde yazılmış olan Molecular Pathology&nbsp; kitabı çevirimiz hala pek çok konuda aydınlatıcı, ama bu kitabı yazarken değişimin hızını bir kez&nbsp;daha hissettik. Önceki kitaptan farklı olarak organ sistemleri bazında sistemik moleküler patoloji bu kitapta yer almıyor ama moleküler patolojinin içiçe&nbsp;çalıştığı biyoinformatik konusuna olabildiğince çok yer ayırdık ve rutin uygulamalarımızdan olgu sunumları ekledik.&nbsp;</p

Biomarkers in Carcinoma of Unknown Primary

A biomarker is a feature that is shown to indicate a physiologic or pathologic condition. The roles of biomarkers in histopathological evaluation are expanding, and pathologists must work with these tools like a conductor of an orchestra. Diagnostic, prognostic, and predictive biomarkers support patient diagnosis and treatment in multiple ways. Some biomarkers are patient-related, and some are drug-related. A single biomarker is sometimes important for all these purposes. Finding biomarkers is a multistep process and requires integrated study of different disciplines. Standards for quality, sensitivity, and specificity of biomarkers are described internationally, and a biomarker should meet all these criteria being used in patient care. Immunohistochemistry, in situ hybridization, polymerase chain reaction, sequencing, and bioinformatic facilities are required for proper diagnosis in a pathology laboratory.</p

Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective

Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chromosomal rearrangements including CRTC1-MAML2 and CRTC3-MAML2 in mucoepidermoid carcinoma, MYB-NFIB and MYBL1-NFIB fusions in adenoid cystic carcinoma, PLAG1 and HMGA2 alterations in pleomorphic adenoma and carcinoma ex pleomorphic adenoma, ETV6-NTRK3 and ETV6-RET in secretory carcinoma, EWSR1-ATF1 and EWSR1-CREM in clear cell carcinoma, provide new insights into the molecular pathogenesis of various salivary gland neoplasms and help to better classify them. These genetic aberrations primarily serve as diagnostic tools in salivary gland tumor diagnosis; however, some also have promise as prognostic or predictive biomarkers. This review summarizes the latest developments in molecular pathology of salivary gland tumors with a focus on distinctive molecular characteristics

Gastrointestinal Stromal Tumors with PDGFRA-D842V Mutation: Single Center Experience for the Frequency, Morphological and Prognostic Features

Objective: PDGFRA mutations are detected rarely in gastrointestinal stromal tumors (GIST), almostalways in gastric tumors and mostly related with epithelioid type and low mitotic index. Exon 18-D842Vmutations, the frequency of which is reported to be ~6%, constitutes the majority of PDGFRA mutations.In this study, we aimed to determine the frequency and clinicopathological features of PDGFRA-D842Vmutated GISTs. Materials and Methods: Among the patients with GIST who underwent PDGFRAmutation analysis with pyrosequencing tecnique between 2016-2022, the cases with Exon 18 D842Vmutation were indentified and the clinicopathologic features were examined.Results: Eighty-nine caseswith GIST underwent PDGFRA mutation analysis and 4 cases showed PDGFRA Exon 18-D842Vmutation (4.5%). Male: female ratio was 1. Median age was 58. All tumors were gastric. Two cases hadmixed, one had epitheloid and one had spindle cell morphology. Two tumors showed low risk, twotumors showed high risk features for progression. The tumors with high progression risk exhibited10th UTSAK, 27-28 August 2022, ANKARA| 462numerous mitoses with the count of 50/ 5 mm2. All cases but one are alive, being followed and have nosign of recurrence. Conclusion: In our study, the frequency of D842V mutation is detected slightly lowerthan the literature, which may be due to populational differences. The most striking finding is that thismutation can also be detected in tumors with high progression risk and intense mitotic activity.Keywords: Gastrointestinal Stromal Tumor, Pdgfra Mutation, D842v Mutation</p