516 research outputs found
Photon Sorting, Efficient Bell Measurements and a Deterministic CZ Gate using a Passive Two-level Nonlinearity
Although the strengths of optical non-linearities available experimentally
have been rapidly increasing in recent years, significant challenges remain to
using such non-linearities to produce useful quantum devices such as efficient
optical Bell state analysers or universal quantum optical gates. Here we
describe a new approach that avoids the current limitations by combining strong
non-linearities with active Gaussian operations in efficient protocols for Bell
state analysers and Controlled-Sign gates
Targeting of the master receptor MOM19 to mitochondria
The targeting of proteins to mitochondria involves the recognition of the precursor proteins by receptors on the mitochondrial surface followed by insertion of the precursors into the outer membrane at the general insertion site GIP. Most mitochondrial proteins analyzed so far use a mitochondrial outer membrane protein of 19 kilodaltons (MOM19) as an import receptor. The gene encoding MOM19 has now been isolated. The deduced amino acid sequence predicts that MOM19 is anchored in the outer membrane by an NH2-terminal hydrophobic sequence, while the rest of the protein forms a hydrophilic domain exposed to the cytosol. MOM19 was targeted to the mitochondria via a pathway that is independent of protease-accessible surface receptors and controlled by direct assembly of the MOM19 precursor with GIP
Transport of proteins into the various subcompartments of mitochondria
The import of proteins into mitochondria is an intricate process comprised of multiple steps. The first step involves the sorting of cytosolically synthesized precursor proteins to the mitochondrial surface. There precursor proteins are recognized by specific receptors which deliver them to the general import site present in the outer membrane. The second stage of import involves a series of complex intraorganelle sorting events which results in the delivery of the proteins to one of the four possible submitochondrial destinations, namely the outer and inner membranes, the matrix and intermembrane space. Here in this review, we discuss the current knowledge on these intramitochondrial sorting events. We especially focus on targetting of proteins to the intermembrane space. Sorting to the intermembrane space represents a particularly interesting situation, as at least three separate targetting pathways to this subcompartment are known to exist
Import of ADP/ATP carrier into mitochondria
We have identified the yeast homologue of Neurospora crassa MOM72, the mitochondrial import receptor for the ADP/ATP carrier (AAC), by functional studies and by cDNA sequencing. Mitochondria of a yeast mutant in which the gene for MOM72 was disrupted were impaired in specific binding and import of AAC. Unexpectedly, we found a residual, yet significant import of AAC into mitochondria lacking MOM72 that occurred via the receptor MOM19. We conclude that both MOM72 and MOM19 can direct AAC into mitochondria, albeit with different efficiency. Moreover, the precursor of MOM72 apparently does not require a positively charged sequence at the extreme amino terminus for targeting to mitochondria
Characterizing heralded single-photon sources with imperfect measurement devices
Any characterization of a single-photon source is not complete without
specifying its second-order degree of coherence, i.e., its function.
An accurate measurement of such coherence functions commonly requires
high-precision single-photon detectors, in whose absence, only time-averaged
measurements are possible. It is not clear, however, how the resulting
time-averaged quantities can be used to properly characterize the source. In
this paper, we investigate this issue for a heralded source of single photons
that relies on continuous-wave parametric down-conversion. By accounting for
major shortcomings of the source and the detectors--i.e., the multiple-photon
emissions of the source, the time resolution of photodetectors, and our chosen
width of coincidence window--our theory enables us to infer the true source
properties from imperfect measurements. Our theoretical results are
corroborated by an experimental demonstration using a PPKTP crystal pumped by a
blue laser, that results in a single-photon generation rate about 1.2 millions
per second per milliwatt of pump power. This work takes an important step
toward the standardization of such heralded single-photon sources.Comment: 18 pages, 9 figures; corrected Eq. (11) and the description follows
Eq. (22
Near-unity coupling efficiency of a quantum emitter to a photonic-crystal waveguide
A quantum emitter efficiently coupled to a nanophotonic waveguide constitutes
a promising system for the realization of single-photon transistors,
quantum-logic gates based on giant single-photon nonlinearities, and high
bit-rate deterministic single-photon sources. The key figure of merit for such
devices is the -factor, which is the probability for an emitted single
photon to be channeled into a desired waveguide mode. We report on the
experimental achievement of for a quantum dot
coupled to a photonic-crystal waveguide, corresponding to a single-emitter
cooperativity of . This constitutes a nearly ideal
photon-matter interface where the quantum dot acts effectively as a 1D
"artificial" atom, since it interacts almost exclusively with just a single
propagating optical mode. The -factor is found to be remarkably robust
to variations in position and emission wavelength of the quantum dots. Our work
demonstrates the extraordinary potential of photonic-crystal waveguides for
highly efficient single-photon generation and on-chip photon-photon
interaction
Реализация информационной системы учета и анализа закупок сырья и материалов для металлургического производства
Single-photon nonlinear optics with a quantum dot in a waveguide
Strong nonlinear interactions between photons enable logic operations for
both classical and quantum-information technology. Unfortunately, nonlinear
interactions are usually feeble and therefore all-optical logic gates tend to
be inefficient. A quantum emitter deterministically coupled to a propagating
mode fundamentally changes the situation, since each photon inevitably
interacts with the emitter, and highly correlated many-photon states may be
created . Here we show that a single quantum dot in a photonic-crystal
waveguide can be utilized as a giant nonlinearity sensitive at the
single-photon level. The nonlinear response is revealed from the intensity and
quantum statistics of the scattered photons, and contains contributions from an
entangled photon-photon bound state. The quantum nonlinearity will find
immediate applications for deterministic Bell-state measurements and
single-photon transistors and paves the way to scalable waveguide-based
photonic quantum-computing architectures
A t-SNARE of the endocytic pathway must be activated for fusion
The t-SNARE in a late Golgi compartment (Tlg2p) syntaxin is required for endocytosis and localization of cycling proteins to the late Golgi compartment in yeast. We show here that Tlg2p assembles with two light chains, Tlg1p and Vti1p, to form a functional t-SNARE that mediates fusion, specifically with the v-SNAREs Snc1p and Snc2p. In vitro, this t-SNARE is inert, locked in a nonfunctional state, unless it is activated for fusion. Activation can be mediated by a peptide derived from the v-SNARE, which likely bypasses additional regulatory proteins in the cell. Locking t-SNAREs creates the potential for spatial and temporal regulation of fusion by signaling processes that unleash their fusion capacity
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