4-(4-bromophenyl)-2-methyl-1,3-thiazole

In the structure of the title compound, C10H8BrNS, the dihedral angles between the planes of the thiazole and aryl rings, viz. 4.2 (6) and 7.5 (6)degrees for the two independent molecules, are consistent with insignificant molecular perturbation by the weak intermolecular contacts. The molecules are close to being related by a non-crystallographic inversion centre, with C-H...pi and pi-pi intermolecular interactions observed

Flat versus twisted rotamers of 2,4-disubstituted thiazoles: the effect of intermolecular hydrogen bonds

In the title compounds, 2-amino-4-(2-chLoro-4,5-dimethoxyphenyl)-1,3-thiazole, C11H11ClN2O2S, (I), and 4-(2-chLoro-4,5-dimethoxyphenyl)-2-methyl-1,3-thiazole, C12H12ClNO2S, (II), the dihedral angles between the thiazole moiety and the chLoroaryl group are 51.61 (10) and 8.44 (14)degrees, respectively. This difference is a consequence of intermolecular hydrogen bonds forcing the stabilization of a twisted rotamer in (I). Substitution of the amino function by a methyl group precludes these contacts, giving a flat rotamer in (II)