8 research outputs found
From photoinduced to dark cytotoxicity via an octahedral cluster hydrolysis
Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum
Π₯ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΠΎΠ·Π½Π°Π½ΠΈΡ: ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΠ±ΡΠ΅ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΎΠ±ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΈ Β«Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΡ Π°Π½Π΅ΡΡΠ΅Π·ΠΈΠΎΠ»ΠΎΠ³ΠΎΠ² ΠΈ ΡΠ΅Π°Π½ΠΈΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ²Β»
Π₯ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΠΎΠ·Π½Π°Π½ΠΈΡ (Π₯ΠΠ‘) ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠΎΠ±ΠΎΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌΡ ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΡΠ΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΠΈΠ΅ ΠΊΒ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π³ΡΡΠ±ΠΎΠΉ ΠΈΠ½Π²Π°Π»ΠΈΠ΄ΠΈΠ·Π°ΡΠΈΠΈ ΠΈΒ ΡΡΠ΅Π±ΡΡΡΠΈΠ΅ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΠΈΠ»ΠΈΠΉ ΠΏΠΎΒ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈΒ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ Π»ΠΎΠΆΠ°ΡΡΡ Π½Π°Β ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠ΅ ΡΡΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΈΒ Π½Π°Β ΠΏΠ»Π΅ΡΠΈ Π±Π»ΠΈΠ·ΠΊΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². Π₯ΠΠ‘ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΡΡ ΡΒ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎΡΠ»Π΅ ΠΊΠΎΠΌΡ ΠΈΒ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π±ΠΎΠ΄ΡΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΠΏΠΎΠ»Π½ΠΎΠΌ ΠΈΠ»ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ ΠΏΠΎΠ»Π½ΠΎΠΌ ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΎΡΠΎΠ·Π½Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ. ΠΒ Π₯ΠΠ‘ ΠΎΡΠ½ΠΎΡΡΡΡΡ Π²Π΅Π³Π΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ (ΠΠ‘) ΠΈΒ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ·Π½Π°Π½ΠΈΡ (Π‘ΠΠ‘). Π’Π°ΠΊΠΆΠ΅ Π΄Π»Ρ ΠΎΠΏΠΈΡΠ°Π½ΠΈΡ Π½Π°ΡΠ°Π»ΡΠ½ΡΡ
ΡΡΠ°Π΄ΠΈΠΉ ΡΡΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΡΡΡ ΡΠ΅ΡΠΌΠΈΠ½ Β«ΠΏΡΠΎΠ΄Π»Π΅Π½Π½ΠΎΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ·Π½Π°Π½ΠΈΡΒ» (ΠΠΠ‘). ΠΡΠ΄Π΅Π»ΡΠ½ΠΎ Π²ΡΠ΄Π΅Π»ΡΡΡ Π²ΡΡ
ΠΎΠ΄ ΠΈΠ·Β Π‘ΠΠ‘Β β ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΠΎΡΠΌΠΈΡΡΠ΅ΡΡΡ ΠΏΠΎΒ ΠΌΠ΅ΡΠ΅ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ. ΠΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ°Β Π₯ΠΠ‘ ΠΎΡΠ½ΠΎΠ²ΡΠ²Π°Π΅ΡΡΡ Π½Π°Β ΠΌΠ½ΠΎΠ³ΠΎΠΊΡΠ°ΡΠ½ΠΎΠΌ ΡΡΡΡΠΊΡΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΎΡΠΌΠΎΡΡΠ΅ ΡΒ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΊΠ°Π» ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΠΈ ΠΈΡΠΊΠ»ΡΡΠ΅Π½ΠΈΡ ΠΎΠ±ΡΠ°ΡΠΈΠΌΡΡ
ΠΏΡΠΈΡΠΈΠ½ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΠΎΠ·Π½Π°Π½ΠΈΡ. ΠΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΒ Π₯ΠΠ‘ Π²ΠΊΠ»ΡΡΠ°Π΅Ρ Π²Β ΡΠ΅Π±Ρ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎ Π²Π°ΠΆΠ½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ, ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΈΡΠ°Π½ΠΈΡ ΠΈΒ Π±ΠΎΡΡΠ±Ρ ΡΒ ΡΠΈΠΏΠΈΡΠ½ΡΠΌΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡΠΌΠΈ ΠΈΒ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠΈΠΌΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡΠΌΠΈ (ΠΏΡΠΎΠ»Π΅ΠΆΠ½ΠΈ, ΡΠΏΠ°ΡΡΠΈΡΠ½ΠΎΡΡΡ, Π±ΠΎΠ»Ρ, ΠΏΠ°ΡΠΎΠΊΡΠΈΠ·ΠΌΠ°Π»ΡΠ½Π°Ρ ΡΠΈΠΌΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π³ΠΈΠΏΠ΅ΡΠ°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΒ Π΄Ρ.). Π£Β ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΒ Π₯ΠΠ‘ Π΄ΠΎΠ»ΠΆΠ½Π° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡΡ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΡ ΡΒ ΡΡΠ°ΡΡΠΈΠ΅ΠΌ ΠΌΡΠ»ΡΡΠΈΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΠΎΠΉ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΊΠΎΠΌΠ°Π½Π΄Ρ Π²Β ΠΎΠ±ΡΠ΅ΠΌΠ΅, ΠΊΠΎΡΠΎΡΡΠΉ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌΠΈ ΠΈΒ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΠΌΠΈ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΠΈ Π΅Π΅Β ΡΠ°Π½Π½Π΅Π³ΠΎ Π½Π°ΡΠ°Π»Π°. ΠΠ°Β Π΄Π°Π½Π½ΡΠΉ ΠΌΠΎΠΌΠ΅Π½Ρ ΠΎΠ΄Π½ΠΎΠ·Π½Π°ΡΠ½ΡΡ
Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡΡΠ² ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ°ΠΊΠΈΡ
-Π»ΠΈΠ±ΠΎ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ², Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΡ
Π½Π°Β Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠΎΠ·Π½Π°Π½ΠΈΡ, Π½Π΅Β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΎ; ΠΈΠ·ΡΡΠ°Π΅ΡΡΡ ΡΡΠ΄ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΒ Π½Π΅ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ², ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΠ½ΡΠΌ ΡΡΠ»ΠΎΠ²ΠΈΠ΅ΠΌ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΡΠΎΡΡΡ
ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Π°Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡ ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°. ΠΠ°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ Π²Β Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΒ Π₯ΠΠ‘ ΠΈΠ³ΡΠ°Π΅Ρ Π²ΠΎΠ²Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π±Π»ΠΈΠ·ΠΊΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅, Π²Β ΡΠ²ΠΎΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ, Π½ΡΠΆΠ΄Π°ΡΡΡΡ Π²Β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠΈ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎΒ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΈ ΡΠ²ΠΎΠ΅Π³ΠΎ ΡΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΈΠΊΠ° ΠΈΒ ΠΎΒ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡΡ
ΡΠ΅Π°Π±ΠΈΠ»ΠΈΡΠ°ΡΠΈΠΈ, Π°Β ΡΠ°ΠΊΠΆΠ΅ Π²Β ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ
STABILIZATION OF THE WEATHERED SOILS AND FORMATION OF PERMANENT GRASS GREEN COVER BY CRYOSTRUCTURING
A new chemical-biological method of preventing soil erosion using cryogel in combination with perennial grasses is proposed. The cryogel is shown not to have negative impact on aboriginal soil microflora. On the one hand the cryogel polymer matrix in the soil is strong enough to withstand the effects of erosion but on the other hand it is quite elastic, so it will not hinder plant growth. The seeds germinated through the cryogel layer form a stable green cover. Cryogels are harmless to humans and environmentally friendly
Comparative assessment of drag reduction efficiencies of polymer solutions and surfactants at low temperatures
The mechanical properties of single crystals of irradiatedΞ±-uranium with free or restrained radiation growth
Effect of temperature and neutron irradiation on the plastic deformation of ?-uranium single crystals
Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re<sub>6</sub>Q<sub>8</sub>}(CN)<sub>6</sub>]<sup>4β</sup> (Q = S, Se, Te)
Octahedral rhenium cluster complexes
have recently emerged as relevant building blocks for the design of
singlet oxygen photosensitizing materials toward biological applications
such as blue-light photodynamic therapy. However, their singlet oxygen
generation ability as well as biological properties have been studied
only superficially. Herein we investigate in detail the singlet oxygen
photogeneration, dark and photoinduced cytotoxicity, cellular uptake
kinetics, cellular localization and in vitro photoinduced oxidative
stress, and photodynamic cytotoxicity of the series of octahedral
rhenium cluster complexes [{Re<sub>6</sub>Q<sub>8</sub>}Β(CN)<sub>6</sub>]<sup>4β</sup>, where Q = S, Se, Te. Our results demonstrate
that the selenium-containing complex possesses optimal properties
in terms of absorption and singlet oxygen productivity. These features
coupled with the cellular internalization and low dark toxicity lead
to the first photoinduced cytotoxic effect observed for a molecular
[{M<sub>6</sub>Q<sub>8</sub>}ΒL<sub>6</sub>] complex, making it a promising
object for further study in terms of blue-light PDT