6 research outputs found
Civil Aspects of Intrafamily Eavesdropping in Illinois: Caveats to Comprehensive Remedial Weaponry, 12 J. Marshall J. Prac. & Proc. 537 (1979)
Hewitt v. Hewitt - Contract Cohabitation and Equitable Expectations - Relief for Meretricious Spouses, 12 J. Marshall J. Prac. & Proc. 435 (1979)
Associations of urinary non-persistent endocrine disrupting chemical biomarkers with early-to-mid pregnancy plasma sex-steroid and thyroid hormones
Background/Objectives: Pregnant women are exposed to numerous endocrine disrupting chemicals (EDCs) that can affect hormonal pathways regulating pregnancy outcomes and fetal development. Thus, we evaluated overall and fetal sex-specific associations of phthalate/replacement, paraben, and phenol biomarkers with sex-steroid and thyroid hormones. Methods: Illinois women (n = 302) provided plasma for progesterone, estradiol, testosterone, free T4 (FT4), total T4 (TT4), and thyroid stimulating hormone (TSH) at median 17 weeks gestation. Women also provided up-to-five first-morning urine samples monthly across pregnancy (8â40 weeks), which we pooled to measure 19 phthalate/replacement metabolites (reflecting ten parent compounds), three parabens, and six phenols. We used linear regression to evaluate overall and fetal sex-specific associations of biomarkers with hormones, as well as weighted quantile sum and Bayesian kernel machine regression (BKMR) to assess cumulative associations, non-linearities, and chemical interactions. Results: In women of relatively high socioeconomic status, several EDC biomarkers were associated with select hormones, without cumulative or non-linear associations with progesterone, FT4, or TT4. The biomarker mixture was negatively associated with estradiol (only at higher biomarker concentrations using BKMR), testosterone, and TSH, where each 10% mixture increase was associated with â5.65% (95% CI: â9.79, â1.28) lower testosterone and â0.09 ÎŒIU/mL (95% CI: â0.20, 0.00) lower TSH. Associations with progesterone, testosterone, and FT4 did not differ by fetal sex. However, in women carrying females, we identified an inverted u-shaped relationship of the mixture with estradiol. Additionally, in women carrying females, each 10% increase in the mixture was associated with 1.50% (95% CI: â0.15, 3.18) higher TT4, whereas in women carrying males, the mixture was associated with â1.77% (95% CI: â4.08, 0.58) lower TT4 and â0.18 ÎŒIU/mL (95% CI: â0.33, â0.03) lower TSH. We also identified select chemical interactions. Conclusion: Some biomarkers were associated with early-to-mid pregnancy hormones. There were some sex-specific and non-linear associations. Future studies could consider how these findings relate to pregnancy/birth outcomes
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Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
Prenatal per- and poly-fluoroalkyl substances (PFAS) exposure may influence gestational outcomes through bioactive lipidsâmetabolic and inflammation pathway indicators. We estimated associations between prenatal PFAS exposure and bioactive lipids, measuring 12 serum PFAS and 50 plasma bioactive lipids in 414 pregnant women (median 17.4 weeks' gestation) from three Environmental influences on Child Health Outcomes Program cohorts. Pairwise association estimates across cohorts were obtained through linear mixed models and meta-analysis, adjusting the former for false discovery rates. Associations between the PFAS mixture and bioactive lipids were estimated using quantile g-computation. Pairwise analyses revealed bioactive lipid levels associated with PFDeA, PFNA, PFOA, and PFUdA (p < 0.05) across three enzymatic pathways (cyclooxygenase, cytochrome p450, lipoxygenase) in at least one combined cohort analysis, and PFOA and PFUdA (q < 0.2) in one linear mixed model. The strongest signature revealed doubling in PFOA corresponding with PGD2 (cyclooxygenase pathway; +24.3%, 95% CI: 7.3-43.9%) in the combined cohort. Mixture analysis revealed nine positive associations across all pathways with the PFAS mixture, the strongest signature indicating a quartile increase in the PFAS mixture associated with PGD2 (+34%, 95% CI: 8-66%), primarily driven by PFOS. Bioactive lipids emerged as prenatal PFAS exposure biomarkers, deepening insights into PFAS' influence on pregnancy outcomes
Spin density matrix elements in exclusive
We report on a measurement of Spin Density Matrix Elements (SDMEs) in hard exclusive meson muoproduction at COMPASS using 160Â GeV/c polarised and beams impinging on a liquid hydrogen target. The measurement covers the kinematic range 5.0Â GeV/ 17.0Â GeV/, 1.0 (GeV/c) 10.0 (GeV/c) and 0.01 (GeV/c) 0.5 (GeV/c). Here, W denotes the mass of the final hadronic system, the virtuality of the exchanged photon, and the transverse momentum of the meson with respect to the virtual-photon direction. The measured non-zero SDMEs for the transitions of transversely polarised virtual photons to longitudinally polarised vector mesons () indicate a violation of s-channel helicity conservation. Additionally, we observe a dominant contribution of natural-parity-exchange transitions and a very small contribution of unnatural-parity-exchange transitions, which is compatible with zero within experimental uncertainties. The results provide important input for modelling Generalised Parton Distributions (GPDs). In particular, they may allow one to evaluate in a model-dependent way the role of parton helicity-flip GPDs in exclusive production
Spin density matrix elements in exclusive meson muoproduction
We report on a measurement of Spin Density Matrix Elements (SDMEs) in hard exclusive meson muoproduction at COMPASS using 160~GeV/ polarised and beams impinging on a liquid hydrogen target. The measurement covers the kinematic range 5.0~GeV/ 17.0~GeV/, 1.0 (GeV/) 10.0 (GeV/) and 0.01 (GeV/) 0.5 (GeV/). Here, denotes the mass of the final hadronic system, the virtuality of the exchanged photon, and the transverse momentum of the meson with respect to the virtual-photon direction. The measured non-zero SDMEs for the transitions of transversely polarised virtual photons to longitudinally polarised vector mesons () indicate a violation of -channel helicity conservation. Additionally, we observe a dominant contribution of natural-parity-exchange transitions and a very small contribution of unnatural-parity-exchange transitions, which is compatible with zero within experimental uncertainties. The results provide important input for modelling Generalised Parton Distributions (GPDs). In particular, they may allow one to evaluate in a model-dependent way the role of parton helicity-flip GPDs in exclusive production.We report on a measurement of Spin Density Matrix Elements (SDMEs) in hard exclusive meson muoproduction at COMPASS using 160Â GeV/c polarised and beams impinging on a liquid hydrogen target. The measurement covers the kinematic range 5.0Â GeV/ 17.0Â GeV/, 1.0 (GeV/c) 10.0 (GeV/c) and 0.01 (GeV/c) 0.5 (GeV/c). Here, W denotes the mass of the final hadronic system, the virtuality of the exchanged photon, and the transverse momentum of the meson with respect to the virtual-photon direction. The measured non-zero SDMEs for the transitions of transversely polarised virtual photons to longitudinally polarised vector mesons () indicate a violation of s-channel helicity conservation. Additionally, we observe a dominant contribution of natural-parity-exchange transitions and a very small contribution of unnatural-parity-exchange transitions, which is compatible with zero within experimental uncertainties. The results provide important input for modelling Generalised Parton Distributions (GPDs). In particular, they may allow one to evaluate in a model-dependent way the role of parton helicity-flip GPDs in exclusive production.We report on a measurement of Spin Density Matrix Elements (SDMEs) in hard exclusive meson muoproduction at COMPASS using 160~GeV/ polarised and beams impinging on a liquid hydrogen target. The measurement covers the kinematic range 5.0~GeV/ 17.0~GeV/, 1.0 (GeV/) 10.0 (GeV/) and 0.01 (GeV/) 0.5 (GeV/). Here, denotes the mass of the final hadronic system, the virtuality of the exchanged photon, and the transverse momentum of the meson with respect to the virtual-photon direction. The measured non-zero SDMEs for the transitions of transversely polarised virtual photons to longitudinally polarised vector mesons () indicate a violation of -channel helicity conservation. Additionally, we observe a dominant contribution of natural-parity-exchange transitions and a very small contribution of unnatural-parity-exchange transitions, which is compatible with zero within experimental uncertainties. The results provide important input for modelling Generalised Parton Distributions (GPDs). In particular, they may allow one to evaluate in a model-dependent way the role of parton helicity-flip GPDs in exclusive production