Extreme mass ratio inspirals on the equatorial plane in the adiabatic order

We compute gravitational waves from inspiraling stellar-mass compact objects on the equatorial plane of a massive spinning black hole (BH). Our inspiral orbits are computed by taking into account the adiabatic change of orbital parameters due to gravitational radiation in the lowest order in mass ratio. We employ an interpolation method to compute the adiabatic change at arbitrary points inside the region of orbital parameter space computed in advance. Using the obtained inspiral orbits and associated gravitational waves, we compute power spectra of gravitational waves and the signal-to-noise ratio (SNR) for several values of the BH spin, the masses of the binary, and the initial orbital eccentricity during a hypothetical three-yrs LISA observation before final plunge. We find that (i) the SNR increases as the BH spin and the mass of the compact object increase for the BH mass M \agt 10^6M_\odot, (ii) the SNR has a maximum for $M \approx 10^6M_\odot$, and (iii) the SNR increases as the initial eccentricity increases for $M=10^6M_\odot$. We also show that incorporating the contribution from the higher multipole modes of gravitational waves is crucial for enhancing the detection rate.Comment: 18 pages, 18 figures, published in Phys. Rev. D, supplementary data files available at https://sites.google.com/view/bhpc1996/hom

A Review of Whether a Difference in the Protein-to-Energy Ratio of Breakfast Would Affect Subsequent Appetite

departmental bulletin pape

A soft-core processor for finite field arithmetic with a variable word size accelerator

This paper presents implementation and evaluation of an accelerator architecture for soft-cores to speed up reduction process for the arithmetic on GF(2m) used in Elliptic Curve Cryptography (ECC) systems. In this architecture, the word size of the accelerator can be customized when the architecture is configured on an FPGA. Focusing on the fact that the number of the reduction processing operations on GF(2m) is affected by the irreducible polynomial and the word size, we propose to employ an unconventional word size for the accelerator depending on a given irreducible polynomial and implement a MIPS-based soft-core processor coupled with a variable-word size accelerator. As a result of evaluation with several polynomials, it was shown that the performance improvement of up to 10.2 times was obtained compared to the 32-bit word size, even taking into account the maximum frequency degradation of 20.4% caused by changing the word size. The advantage of using unconventional word sizes was also shown, suggesting the promise of this approach for low-power ECC systems.24th International Conference on Field Programmable Logic and Applications, FPL 2014; Technische Universitat MunchenMunich; Germany; 1 September 2014 through 5 September 201

The Importance of Suppressing Pathological Periostin Splicing Variants with Exon 17 in Both Stroma and Cancer

Shibata Kana, Koibuchi Nobutaka, Sanada Fumihiro, et al. The Importance of Suppressing Pathological Periostin Splicing Variants with Exon 17 in Both Stroma and Cancer. Cells 13, 1410 (2024); https://doi.org/10.3390/cells13171410.Background: Periostin (POSTN) is a type of matrix protein that functions by binding to other matrix proteins, cell surface receptors, or other molecules, such as cytokines and proteases. POSTN has four major splicing variants (PN1–4), which are primarily expressed in fibroblasts and cancer. We have reported that we should inhibit pathological POSTN (PN1–3), but not physiological POSTN (PN4). In particular, pathological POSTN with exon 17 is present in both stroma and cancer, but it is unclear whether the stroma or cancer pathological POSTN should be suppressed. Methods and Results: We transplanted 4T1 cells (breast cancer) secreting POSTN with exon 17 into 17KO mice lacking POSTN exon 17 to suppress stromal POSTN with exon 17. The results show that 17KO mice had smaller primary tumors and fewer metastases. Furthermore, to suppress cancer POSTN with exon 17, 4T1 cells transfected with POSTN exon 17 skipping oligo or control oligo were transplanted from the tail vein into the lungs. The results show that POSTN exon 17 skipping oligo significantly suppressed lung metastasis. Conclusions: These findings suggest that it is important to suppress POSTN exon 17 in both stroma and cancer. Antibody targeting POSTN exon 17 may be a therapeutic candidate for breast cancer

Astrometry of Water Maser Sources in Nearby Molecular Clouds with VERA - II. SVS 13 in NGC 1333

We report on the results of multi-epoch VLBI observations with VERA (VLBI Exploration of Radio Astrometry) of the 22 GHz H2O masers associated with the young stellar object SVS 13 in the NGC 1333 region. We have carried out phase-referencing VLBI astrometry and measured an annual parallax of the maser features in SVS 13 of 4.25+/-0.32 mas, corresponding to the distance of 235+/-18 pc from the Sun. Our result is consistent with a photometric distance of 220 pc previously reported. Even though the maser features were detectable only for 6 months, the present results provide the distance to NGC 1333 with much higher accuracy than photometric methods. The absolute positions and proper motions have been derived, revealing that the H2O masers with the LSR (local standard of rest) velocities of 7-8 km s-1 are most likely associated with VLA4A, which is a radio counterpart of SVS 13. The origin of the observed proper motions of the maser features are currently difficult to attribute to either the jet or the rotating circumstellar disk associated with VLA4A, which should be investigated through future high-resolution astrometric observations of VLA4A and other radio sources in NGC 1333.Comment: 9 pages, 5 figures. PASJ, in press (2008, Vol. 60, No. 1

Astrometry of Galactic Star Forming Region Sharpless 269 with VERA : Parallax Measurements and Constraint on Outer Rotation Curve

We have performed high-precision astrometry of H2O maser sources in Galactic star forming region Sharpless 269 (S269) with VERA. We have successfully detected a trigonometric parallax of 189+/-8 micro-arcsec, corresponding to the source distance of 5.28 +0.24/-0.22 kpc. This is the smallest parallax ever measured, and the first one detected beyond 5 kpc. The source distance as well as proper motions are used to constrain the outer rotation curve of the Galaxy, demonstrating that the difference of rotation velocities at the Sun and at S269 (which is 13.1 kpc away from the Galaxy's center) is less than 3%. This gives the strongest constraint on the flatness of the outer rotation curve and provides a direct confirmation on the existence of large amount of dark matter in the Galaxy's outer disk.Comment: 7 pages and 4 figures, Accepted by PASJ (Vol. 59, No. 5, October 25, 2007 issue