A Search for ϕ\phi Meson Nucleus Bound State Using Antiproton Annihilation on Nucleus

n/

Novel quantitative immunohistochemical analysis for evaluating PD-L1 expression with phosphor-integrated dots for predicting the efficacy of patients with cancer treated with immune checkpoint inhibitors

IntroductionProgrammed cell death ligand 1 (PD-L1) expression in tumor tissues is measured as a predictor of the therapeutic efficacy of immune checkpoint inhibitors (ICIs) in many cancer types. PD-L1 expression is evaluated by immunohistochemical staining using 3,3´-diaminobenzidine (DAB) chronogenesis (IHC-DAB); however, quantitative and reproducibility issues remain. We focused on a highly sensitive quantitative immunohistochemical method using phosphor-integrated dots (PIDs), which are fluorescent nanoparticles, and evaluated PD-L1 expression between the PID method and conventional DAB method.MethodsIn total, 155 patients with metastatic or recurrent cancer treated with ICIs were enrolled from four university hospitals. Tumor tissue specimens collected before treatment were subjected to immunohistochemical staining with both the PID and conventional DAB methods to evaluate PD-L1 protein expression.ResultsPD-L1 expression assessed using the PID and DAB methods was positively correlated. We quantified PD-L1 expression using the PID method and calculated PD-L1 PID scores. The PID score was significantly higher in the responder group than in the non-responder group. Survival analysis demonstrated that PD-L1 expression evaluated using the IHC-DAB method was not associated with progression-free survival (PFS) or overall survival (OS). Yet, PFS and OS were strikingly prolonged in the high PD-L1 PID score group.ConclusionQuantification of PD-L1 expression as a PID score was more effective in predicting the treatment efficacy and prognosis of patients with cancer treated with ICIs. The quantitative evaluation of PD-L1 expression using the PID method is a novel strategy for protein detection. It is highly significant that the PID method was able to identify a group of patients with a favorable prognosis who could not be identified by the conventional DAB method

ツウジョウ ゲンシカク ミツドカ ニ オケル ファイ チュウカンシ ノ シツリョウ ヘンカ ニ タイスル ショウコ

京都大学0048新制・論文博士博士(理学)乙第12002号論理博第1477号新制||理||1471(附属図書館)UT51-2007-H557京都大学大学院理学研究科物理学・宇宙物理学専攻(主査)教授 今井 憲一, 教授 笹尾 登, 教授 谷森 達学位規則第4条第2項該当Doctor of ScienceKyoto UniversityDA

Development of a high gradient rf system using a nanocrystalline soft magnetic alloy

The future high intensity upgrade project of the J-PARC (Japan Proton Accelerator Research Complex) MR (Main Ring) includes developments of high gradient rf cavities and magnet power supplies for high repetition rate. The scenario describing the cavity replacements is reported. By the replacement plan, the total acceleration voltage will be almost doubled, while the number of rf stations remains the same. The key issue is the development of a high gradient rf system using high impedance magnetic alloy, FT3L. The FT3L is produced by the transverse magnetic field annealing although the present cavity for the J-PARC adopts the magnetic alloy, FT3M, which is annealed without magnetic field. After the test production using a large spectrometer magnet in 2011, a dedicated production system for the FT3L cores was assembled in 2012. This setup demonstrated that we can produce material with 2 times higher μ_{p}^{′}Qf product compared to the cores used for present cavities. In this summer, the production system was moved to the company from J-PARC and is used for mass production of 280 FT3L cores for the J-PARC MR. The cores produced in the first test production are already used for standard machine operation. The operation experience shows that the power loss in the cores was reduced significantly as expected

Superiority trial comparing intraoperative wound irrigation with aqueous 10% povidone–iodine to saline for the purpose of reducing surgical site infection after elective gastrointestinal surgery: study protocol for a randomised controlled trial

Introduction Surgical site infection (SSI) is one of the most common complications after gastrointestinal surgery, with a reported incidence of approximately 10%–25%, which is higher than the rates after other types of surgery. Intraoperative wound irrigation (IOWI) is a simple intervention for SSI prevention, and recent studies have reported that IOWI with aqueous povidone–iodine (PVP-I) is significantly more effective at reducing the incidence of SSI than saline. However, the evidence level of previous trials evaluating the efficacy of aqueous PVP-I solution for preventing SSI has been low.Methods and analyses We propose a single-institute, prospective, randomised, blinded-endpoint trial to assess the superiority of IOWI with aqueous 10% PVP-I solution compared with normal saline for reducing SSI in clean-contaminated wounds after elective gastrointestinal surgery. In the study group, IOWI with 40 mL of aqueous 10% PVP-I solution is performed for 1 min before skin suture, and in the control group, IOWI with 100 mL of saline is performed for 1 min before skin suture. We hypothesise that IOWI with aqueous 10% PVP-I solution will achieve a 50% reduction in the incidence of SSIs. The target number of cases is set at 950. The primary outcome is the incidence of incisional SSI up to postoperative day 30 and will be analysed in the modified intention-to-treat set.Ethics and dissemination This trial was designed and is being conducted by Saitama Medical Center, Jichi Medical University, with approval from the Bioethics Committee for Clinical Research, Saitama Medical Center, Jichi Medical University. Participant recruitment began in June 2019. The final results will be reported in international peer-reviewed journals immediately after trial completion.Trial registration number UMIN000036889

Monitoring System for the Gold Target by Radiation Detectors in Hadron Experimental Facility at J-PARC

At the Hadron Experimental Facility in J-PARC, we inject a 30-GeV proton beam into a gold target to produce secondary particle beams required for various particle and nuclear physics experiments. The gold target is placed in a hermetic chamber, and helium gas is circulated in the chamber to monitor the soundness of the target. The radioactivity in helium gas is continuously monitored by gamma-ray detectors such as a germanium detector and a NaI(Tl) detector. Beam operations with those target-monitoring systems were successfully performed from April to June and October to December 2015, and from May to June 2016. In this paper, the details of the helium gas circulation system and gamma-ray detectors and the analysis results of the obtained gamma-ray spectra are reported

Monitoring System for the Gold Target by Radiation Detectors in Hadron Experimental Facility at J-PARC

At the Hadron Experimental Facility in J-PARC, we inject a 30-GeV proton beam into a gold target to produce secondary particle beams required for various particle and nuclear physics experiments. The gold target is placed in a hermetic chamber, and helium gas is circulated in the chamber to monitor the soundness of the target. The radioactivity in helium gas is continuously monitored by gamma-ray detectors such as a germanium detector and a NaI(Tl) detector. Beam operations with those target-monitoring systems were successfully performed from April to June and October to December 2015, and from May to June 2016. In this paper, the details of the helium gas circulation system and gamma-ray detectors and the analysis results of the obtained gamma-ray spectra are reported

Search for φ-Meson Nuclear Bound States in the \overlinep + AZ →φ+ A-1φ(Z-1) Reaction

n/