Planetary Systems in Binaries. I. Dynamical Classification

Many recent observational studies have concluded that planetary systems commonly exist in multiple-star systems. At least ~20% of the known extrasolar planetary systems are associated with one or more stellar companions. The orbits of stellar binaries hosting planetary systems are typically wider than 100 AU and often highly inclined with respect to the planetary orbits. The effect of secular perturbations from such an inclined binary orbit on a coupled system of planets, however, is little understood theoretically. In this paper we investigate various dynamical classes of double-planet systems in binaries through numerical integrations and we provide an analytic framework based on secular perturbation theories. Differential nodal precession of the planets is the key property that separates two distinct dynamical classes of multiple planets in binaries: (1) dynamically-rigid systems in which the orbital planes of planets precess in concert as if they were embedded in a rigid disk, and (2) weakly-coupled systems in which the mutual inclination angle between initially coplanar planets grows to large values on secular timescales. In the latter case, the quadrupole perturbation from the outer planet induces additional Kozai cycles and causes the orbital eccentricity of the inner planet to oscillate with large amplitudes. The cyclic angular momentum transfer from a stellar companion propagating inward through planets can significantly alter the orbital properties of the inner planet on shorter timescales. This perturbation propagation mechanism may offer important constraints on the presence of additional planets in known single-planet systems in binaries.Comment: 14 pages, 14 figures, to appear in Ap

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A critical role of holistic processing in face gender perception

Whether face gender perception is processed by encoding holistic (whole) or featural (parts) information is a controversial issue. Although neuroimaging studies have identified brain regions related to face gender perception, the temporal dynamics of this process remain under debate. Here, we identified the mechanism and temporal dynamics of face gender perception. We used stereoscopic depth manipulation to create two conditions: the front and behind condition. In the front condition, facial patches were presented stereoscopically in front of the occluder and participants perceived them as disjoint parts (featural cues). In the behind condition, facial patches were presented stereoscopically behind the occluder and were amodally completed and unified in a coherent face (holistic cues). We performed three behavioral experiments and one electroencephalography experiment, and compared the results of the front and behind conditions. We found faster RT in the behind condition compared with the front, and observed priming effects and aftereffects only in the behind condition. Moreover, the EEG experiment revealed that face gender perception is processed in the relatively late phase of visual recognition (200-285 ms). Our results indicate that holistic information is critical for face gender perception, and that this process occurs with a relatively late latency

Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway

Mitogen-activated protein kinases (MAPKs), which are found in all eukaryotes, are signal transducing enzymes playing a central role in diverse biological processes, such as cell proliferation, sexual differentiation, and apoptosis. The MAPK signaling pathway plays a key role in the regulation of gene expression through the phosphorylation of transcription factors. Recent studies have identified several RNA-binding proteins (RBPs) as regulators of MAPK signaling because these RBPs bind to the mRNAs encoding the components of the MAPK pathway and regulate the stability of their transcripts. Moreover, RBPs also serve as targets of MAPKs because MAPK phosphorylate and regulate the ability of RBPs to bind and stabilize target mRNAs, thus controlling various cellular functions. In this review, we present evidence for the significance of the MAPK signaling in the regulation of RBPs and their target mRNAs, which provides additional information about the regulatory mechanism underlying gene expression. We further present evidence for the clinical importance of the posttranscriptional regulation of mRNA stability and its implications for drug discovery

Stepwise fate conversion of supporting cells to sensory hair cells in the chick auditory epithelium

In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair cells, we used single-cell RNA sequencing during hair cell regeneration in explant cultures of chick basilar papillae. We identified dynamic changes in the gene expression of supporting cells, and the pseudotime trajectory analysis demonstrated the stepwise fate conversion from supporting cells to hair cells. Initially, supporting cell identity was erased and transition to the precursor state occurred. A subsequent gain in hair cell identity progressed together with downregulation of precursor-state genes. Transforming growth factor β receptor 1-mediated signaling was involved in induction of the initial step, and its inhibition resulted in suppression of hair cell regeneration. Our data provide new insights for understanding fate conversion from supporting cells to hair cells in avian basilar papillae