The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18 medical institutions in our prefecture and were diagnosed with LSS-associated intermittent claudication. A second survey was performed after a parts per thousand yen6 weeks for 79 of the subjects to evaluate therapy with limaprost (an oral prostaglandin E1 derivative) or etodolac (an NSAID). Symptoms, maximum walking time, QOL, ADL items, and relationships among these variables were investigated for all 91 patients. Leg pain, leg numbness, and low back pain while walking were surveyed by use of VAS scores (0-100). Leg pain, leg numbness, and low back pain while walking (VAS a parts per thousand yen25) were present in 83.5, 62.6, and 54.9 % of the patients in the first survey, and approximately half of the patients had a maximum walking time 30 min, showing that maximum walking time affected health-related QOL. Of the 79 patients who completed the second survey, 56 had taken limaprost and 23 (control group) had received etodolac. Limaprost improved possible walking time, reduced ADL interference, and significantly increased the EQ-5D utility score, whereas no significant changes occurred in the control group. Maximum walking time was prolonged by a parts per thousand yen10 min and the EQ-5D utility value was improved by a parts per thousand yen0.1 points in significantly more patients in the limaprost group than in the control group. According to the findings of this survey, at an average of 8 weeks after administration limaprost improved symptoms, QOL, and ADL in LSS patients whereas treatment with an NSAID reduced pain but did not have any other effects.ArticleJOURNAL OF ORTHOPAEDIC SCIENCE. 18(2):208-215 (2013)journal articl

ISOLATION OF PROLACTIN BY ACRYLAMIDE GEL ELECTROPHORESIS OF THE RAT PITUITARY TISSUE CULTURE MEDIUM

Biological, chemical, or immunological properties of prolactin are not yet completely understood. The relationship between pituitary prolactin and growth hormone or prolactin-like substance in the fluids such as blood and urine in human is another important problem to study. The relationship between pituitary prolactin and growth hormone or prolactin-like substance in the fluids such as blood and urine in human is another important problem to study. In the present experiment isolation of prolactin from the rat pituitary tissue culture medium was attempted by acrylamide gel electrophoresis, utilizing the fact that the pituitary separated from hypothalamic connection secreted almost exclusively prolactin and that pituitary prolactin increased by estrogen administration. As a result of 7-day culture prolactin band was obtained separately. Presence of growth hormone band even after 7-day culture indicated existence of GIF (growth hormone-inhibiting factor) in the hypothalamus

Research and Development of High-Performance Edge Machine Learning Systems Using Small Time-Series Sensing Data

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