Status of adult outpatients with congenital heart disease in Japan: The Japanese Network of Cardiovascular Departments for Adult Congenital Heart Disease Registry

BackgroundThe Japanese Network of Cardiovascular Departments for Adult Congenital Heart Disease (JNCVD-ACHD) was founded in 2011 for the lifelong care of adult patients with congenital heart disease (ACHD patients). This network maintains the first Japanese ACHD registry.Methods and resultsFrom 2011 to 2019, the JNCVD-ACHD registered 54 institutions providing specialized care for ACHD patients in 32 of the 47 prefectures in Japan. The registry collected data on the disease profile for 24,048 patients from 50 institutions and the patient characteristics for 9743 patients from 24 institutions. The most common ACHDs were atrial septal defect (20.5 %), ventricular septal defect (20.5 %), tetralogy of Fallot (12.9 %), and univentricular heart (UVH)/single ventricle (SV; 6.6 %). ACHD patients without biventricular repair accounted for 37.0 % of the population. Also examined were the serious anatomical and/or pathophysiological disorders such as pulmonary arterial hypertension (3.0 %) including Eisenmenger syndrome (1.2 %), systemic right ventricle under biventricular circulation (sRV-2VC; 2.8 %), and Fontan physiology (6.0 %). The sRV-2VC cases comprised congenitally corrected transposition of the great arteries without anatomical repair (61.9 %) and transposition of the great arteries with atrial switching surgery (38.1 %). The primary etiology (86.4 %) for Fontan physiology was UVH/SV. In addition, developmental/chromosomal/genetic disorders were heterotaxy syndromes (asplenia, 0.9 %; polysplenia, 0.7 %), trisomy 21 (4.0 %), 22q11.2 deletion (0.9 %), Turner syndrome (0.2 %), and Marfan syndrome (1.1 %).ConclusionsAlthough the specific management of ACHD has systematically progressed in Japan, this approach is still evolving. For ideal ACHD care, the prospective goals for the JNCVD-ACHD are to create local networks and provide a resource for multicenter clinical trials to support evidence-based practice

Zircon sensitive high mass-resolution ion microprobe U-Pb and fission-track ages for gabbros and sheeted dykes of the Taitao ophiolite, Southern Chile, and their tectonic implications

The Late Miocene-Pliocene Taitao ophiolite is composed of a complete sequence of classic oceanic lithosphere and is exposed approximately 50 km southeast of the Chile triple junction, where the Chile Ridge subducts beneath the South American Plate. Gabbros and ultramafic rocks are folded into a complex pattern, but only evidence for block rotation has been reported in the overriding sheeted dyke complex. In the present study, sensitive high mass-resolution ion microprobe U-Pb and fission-track dating methods were applied to zircon crystals separated from gabbros and sheeted dykes. Two sets of radiometric ages of gabbros range between 5.9 ± 0.4 and 5.6 ± 0.1 Ma. These ages coincide within their error ranges and imply rapid intrusion and cooling of gabbros. The U-Pb age of a dacite dyke intruded into the sheeted dyke complex was determined to be 5.2 ± 0.2 Ma. These data indicate that the magmas of the Taitao ophiolite were formed during the 6 Ma Chile Ridge collision event and emplaced in a shorter period than previously thought. A short segment of the Chile Mid-oceanic Ridge must have been emplaced during the 6 Ma event

Circularly polarized luminescence from a common alkoxy pillar[5]arene and its co‐aggregates with π‐conjugated rods

Abstract Cylinder‐shaped macrocycles composed of π‐panels have attracted special attention as one of the best platforms for the development of organic molecule‐based chiroptical materials. Pillar[n]arenes are a class of macrocycles with the advantage of easy preparation but have not been extensively investigated from the perspective of luminescent molecules. However, common alkoxy pillar[n]arenes are fluorescent in non‐haloalkane solvents, showing potential to be used for molecule‐based chiroptical materials. In this work, circularly polarized luminescence (CPL) spectra are reported for a pillar[5]arene with stable planar chirality using tetrahydrofuran (THF) and cyclohexane as solvents, which has been missing for many years. The pillar[5]arene also forms co‐aggregates with 1,4‐bis(phenylethynyl)benzene and 1,4‐bis[(pentafluorophenyl)ethynyl]benzene in THF/H2O mixtures, owing to a hydrophobic effect. The co‐aggregates with the fluorinated π‐rod display a new low‐energy absorption peak and broad emission band as well as intense circular dichroism and CPL signals. Chiral information from the enantiopure pillar[5]arene core is efficiently transmitted to the co‐aggregates with the π‐conjugated rod, leading to the highest dissymmetry factor for CPL (2.9 × 10−2 at 472 nm) among pillar[n]arene‐based CPL materials

Evolution history of the crust underlying Cerro Pampa, Argentine Patagonia: Constraint from LA-ICPMS U-Pb ages for exotic zircons in the Mid-Miocene adakite

This paper newly reports results of LA-ICPMS U-Pb dating for 282 zircon crystals separated from a Middle Miocene adakite in Cerro Pampa, southern Argentine Patagonia. With the exception of one spot age, 174 of the U-Pb concordia ages are markedly older (>94 Ma) than the cooling ages of the adakite magma (ca. 12 Ma). The presence of numerous exotic zircon crystals indicates that the adakitic magma carries up information related to the crustal components during its ascent through the entire crust underneath Cerro Pampa. The obtained concordia ages of exotic zircons, 94-1335 Ma, are divisible into five groups having distinctive peaks on a population diagram. The first (94-125 Ma) and second age groups (125-145 Ma) correspond to the age of plutonic activities that formed the main body of the South Patagonian Batholith. The third to fifth groups respectively correspond to activities of the El Qumado-Ibañez volcanic complex (145-170 Ma), plutonic rocks scarcely exposed in Central Patagonia (170-200 Ma), and the Eastern Andean metamorphic complex of Late Paleozoic to Early Mesozoic ages (200-380 Ma). Our data suggest that the crust underneath Cerro Pampa was formed mostly after 380 Ma, the majority forming during the Early Cretaceous to Middle Jurassic. The processes of crustal development ceased for ca. 80 m.y. until the activity of the Cerro Pampa adakite in ca. 12 Ma. In contrast to the existence of numerous Archaean-Palaeoproterozoic exotic zircons in Mesozoic plutonic rocks distributed in Andean Cordillera at around 46°S, no evidence was found for Archaean-Paleoproterozoic crust on the Cerro Pampa region at 48°S. This evidence suggests that two crusts must have aggregated along a boundary between 46°S and 48°S with the continental margin of Gondwana during Late Paleozoic times, as part of the amalgamation of Pangea.Fil: Orihashi, Yuji. The University of Tokyo. Earthquake Research Institute; JapónFil: Anma, Ryo. University of Tsukuba. Graduate School of Life and Environmental Sciences; JapónFil: Motoki, Akihisa. Rio de Janeiro State University. Departamento de Mineralogia e Petrologia Ígnea; BrasilFil: Haller, Miguel Jorge F.. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Hirata, Daiji. Kanagawa Prefecture Museum of Natural History; JapónFil: Iwano, Hideki. Kyoto Fission-Track; JapónFil: Sumino, Hirochika. University of Tokyo. Graduate School of Science. Geochemical Research Center; JapónFil: Ramos, Victor Alberto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Geología. Laboratorio de Tectónica Andina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos; Argentin