Seasonal and interannual variability of the West Greenland Current System in the Labrador Sea in 1993–2008

Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 120 (2015): 1318–1332, doi:10.1002/2014JC010386.The West Greenland Current System (WGCS) transports heat and freshwater into the Labrador Sea, influencing the formation of Labrador Sea Water, a key component of the Atlantic Meridional Overturning Circulation. Notwithstanding its importance, relatively little is known about the structure and transport of this current system and its seasonal and interannual variability. Here we use historical hydrographic data from 1992 to 2008, combined with AVISO satellite altimetry, to diagnose the mean properties as well as seasonal and interannual variability of the boundary current system. We find that while the surface, fresh, cold West Greenland Current is amplified in summer, the subsurface warm, salty Irminger Current has maximum transport in winter, when its waters are also warmer and saltier. Seasonal changes in the total transport are thus mostly due to changes in the baroclinic structure of the current. By contrast, we find a trend toward warmer/saltier waters and a slowdown of the WGCS, within the period studied. The latter is attributed to changes in the barotropic component of the current. Superimposed on this trend, warm and salty anomalies transit through the system in 1997 and 2003 and are associated with a rapid increase in the transport of the boundary current due to changes in the baroclinic component. The boundary current changes precede similar changes in the interior with a 1–2 year lag, indicating that anomalies advected into the region by the boundary current can play an important role in the modulation of convection in the Labrador Sea.T.R. and F.S. were supported by NSF OCE grants 0525929 and 0850416. A.B. was supported by NSF OCE grant 0623192.2015-08-2

Clinical-pharmacological aspects of the choice of phytocomponents for the regulation of the gastrointestinal function

The presentations of dyspepsia include a range of clinical symptoms, each of which has different mechanisms of development, and, therefore, requires different approaches to the correction. In this context, the combination preparations containing components of natural origin with polymodal action on the gastrointestinal tract deserve special attention. Combination of synergistic components: highly bioavailable curcumin and prebiotic fibers; artichoke leaf extract and chamomile flower extract provide simultaneous effects on three key digestive organs: stomach, pancreas and liver. Curcumin has an anti-inflammatory effect, helps to normalize acidity and restore microflora; epithelialization of ulcers; normalization of the gallbladder function; elimination of toxins. It inhibits the processes of primary tumour formation and prevents the development of metastatic processes in gastrointestinal cancer. Pharmaceutical technologies using cyclodextrin as an excipient increase curcumin’s water solubility, dispersibility and absorption, which has been confirmed in several comparative bioavailability studies in healthy volunteers. Chamomile flower extract has anti-inflammatory, antimicrobial, antispasmodic, antiulcer, wound healing and astringent effects. Chamomile is rich in slimy substances that envelop and protect the inflamed mucous membrane, including the stomach, from irritation with hydrochloric acid, bile components, food, and drugs. Mucous substances also have an anti-inflammatory effect and improve digestion. The artichoke facilitates the outflow of bile, affects the secretion of gastric glands, pancreas, increases the enzymatic activity of gastric juice, enhances intestinal motility during its atony, and has a hepatoprotective effect. As can be seen from the above, a combination of these synergistic components can be used in patients with chronic diseases, functional disorders as part of combination therapy, as well as for the prevention of gastrointestinal diseases in healthy people

Circulating microRNAs in lung cancer: prospects for diagnosis, prognosis, and prediction of antitumor treatment efficacy

The review considers the main techniques to extract microRNA (miRNA) from various biological fluids (in particular, the serum and plasma), approaches to the analysis of miRNA concentration and composition, and methods to normalize the results in data analyses. Advantages and drawbacks of the methods are described. Special attention is given to circulating miRNAs, which can be used as markers for minimally invasive diagnosis, prediction of antitumor treatment efficacy, and disease prognosis in lung cancer. The review discusses the prospects and limitations that arise as the clinical significance is evaluated for miRNAs as potential tumor markers and a better understanding is gained for the roles various miRNAs play in the pathogenesis of lung cancer

Characteristics of the epidemic process of whooping cough and its features in a large industrial center of the Middle Urals

The article presents the results of a retrospective analysis of whooping cough in the city of Yekaterinburg in the period from 2013 to 2017 among different age groups and contingents.В статье представлены результаты ретроспективного анализа заболеваемости коклюшем на территории города Екатеринбурга в период с 2013г. по 2017 г. среди различных возрастных групп населения и контингентов

Study of the influence of nutrition factors on the physical development of preschool children

The article presents the results of a comprehensive assessment of the physical development of preschool children (6-7 years old) and their relationship with nutrition in a preschool educational organization. For a complete analysis, an additional survey of parents was conducted. During the study, it became known that children are overweight, there are disorders of the musculoskeletal system and oral hygiene.В статье представлены результаты комплексной оценки физического развития детей дошкольного возраста (6-7лет) и взаимосвязь их с питанием в дошкольной образовательной организации. Для полного анализа дополнительно проведено анкетирование родителей. В ходе исследования стало известно, что у детей наблюдается избыточная масса тела, есть нарушения со стороны костно-мышечного аппаратаивыявлены заболевания полости рта

Circulating DNA-markers in lung cancer: changes in retrotrasposons methylation status in response therapy and during the post-treatment follow-up

Malignant cell transformation is accompanied by two processes of DNA methylation changes

Dynamics of LINE-1 retrotransposon methylation levels in circulating DNA from lung cancer patients undergoing antitumor therapy

Malignant cell transformation is accompanied with abnormal DNA methylation, such as the hypermethylation of certain gene promoters and hypomethylation of retrotransposons. In particular, the hypomethylation of the human-specific family of LINE-1 retrotransposons was observed in lung cancer tissues. It is also known that the circulating DNA (cirDNA) of blood plasma and cell-surface-bound circulating DNA (csb-cirDNA) of cancer patients accumulate tumor-specific aberrantly methylated DNA fragments, which are currently considered to be valuable cancer markers. This work compares LINE-1 retrotransposon methylation patterns in cirDNA of 16 lung cancer patients before and after treatment. CirDNA was isolated from blood plasma, and csb-cirDNA fractions were obtained by successive elution with EDTA-containing phosphate buffered saline and trypsin. Concentrations of methylated LINE-1 region 1 copies (LINE-1-met) were assayed by real-time methylation-specific PCR. LINE-1 methylation levels were normalized to the concentration of LINE-1 region 2, which was independent of the methylation status (LINE-1-Ind). The concentrations of LINE-1-met and LINE-1-Ind in csb-cirDNA of lung cancer patients exhibited correlations before treatment (r = 0.54), after chemotherapy (r = 0.72), and after surgery (r = 0.83) (P 0.05, respectively). These results suggest a need for the further investigation of dynamic changes in levels of LINE-1 methylation depending on the antitumor therapy

Problematic aspects of participation of pharmacists in the system of pharmacovigilance in Russia

In article results pharmacoepidemiology researches on studying of knowledge of pharmacists (n=187) on safety issues medicinal and pharmacovigilance are resulted. 28 % of pharmacists have adverse drug reactions to medicines in the practice, however submit spontaneous messages only 5 % of respondents. Princi pal causes of low activity of pharmacists - a lack of time for drawing up of reports and low level of knowledge in the field of safety of medical products. 89 % of pharmacists need educational programs on pharmacovigilanc

Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation

Tumour development is characterised by the increased circulating DNA (cirDNA) concentration and by tumour-related changes in blood plasma DNA. Concentration of cirDNA and methylation of RARβ2, RASSF1A and HIC-1 gene promoters were investigated in cell-free and cell-surface-bound fractions from healthy donors, patients with breast cancer, and patients with breast fibroadenoma. Tumour development was shown to lead to significant changes in the distribution of cirDNA between cell-free and cell-surface-bound fractions. Analysis of RARβ2 and RASSF1A methylation in the total cirDNA provides 95% diagnostic coverage in breast cancer patients, 60% in patients with benign lesions, and is without false-positive results in healthy women. Results of the study indicate that methylation-specific PCR of RARβ2 and RASSF1A genes based on the total cirDNA combined with the quantitative analysis of cirDNA distribution between cell-bound and cell-free fractions in blood provide the sensitive and accurate detection and discrimination of malignant and benign breast tumours